Serum Uric Acid in Chronic Obstructive Pulmonary Disease: A Hospital Based Case Control Study

Sarangi, Rajlaxmi; Varadhan, Nirupama; Bahinipati, Jyotirmayee; Dhinakaran, Asha; Anandaraj,; Ravichandran, K.

doi:10.7860/jcdr/2017/29300.10605

Cited by 16 publications

(33 citation statements)

References 21 publications

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“…A total of 20 articles were retrieved for full-length article review and 12 articles were excluded at this stage as they did not report the level of serum uric acid among participants with and without COPD. Finally, eight studies [12][13][14][15][16][17][18][19] with 1,612 participants were eligible for the meta-analysis. The literature retrieval, review and selection process are shown in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…The increased level of serum uric acid is thought www.journals.viamedica.pl to be a consequence of increased purine catabolism in the presence of tissue hypoxia [11]. The current systematic review and meta-analysis was conducted to compare serum uric acid level between patients with COPD, a common hypoxemic disorder, and individuals without COPD [12][13][14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

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Chronic Obstructive Pulmonary Disease is Associated with a Higher Level of Serum Uric Acid. A Systematic Review and Meta-Analysis

Wattanachayakul

Rujirachun

Charoenngam

et al. 2020

Advances in Respiratory Medicine

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Introduction: Recent studies have suggested that patients with chronic obstructive pulmonary disease (COPD) may have a higher level of serum uric acid compared with individuals without COPD, although the data are still limited. The current systematic review and meta-analysis was conducted to summarize all available data. Material and methods: A systematic review was performed using the MEDLINE and EMBASE databases from their inception to July 2019. Studies that were eligible for the meta-analysis must have consisted of two groups of participants, patients with COPD and individuals without COPD. The eligible studies must have reported either mean or median level of serum uric acid and its standard deviation (SD) or interquartile range of participants in both groups. Mean serum uric acid level and SD of participants in both groups were extracted from each study and the mean difference (MD) was calculated. Pooled MD was then computed by combining MDs of each study using random effects model. Results: A total of eight studies with 1,612 participants met the eligibility criteria and were included in the data analysis. The serum uric acid level among patients with COPD was significantly higher than individuals without COPD with the pooled MD of 0.91 mg/dL (95% CI: 0.45-1.38; I 2 = 89%). Conclusions: The current study found a significantly higher level of serum uric acid among patients with COPD than individuals without COPD.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chronic Obstructive Pulmonary Disease is Associated with a Higher Level of Serum Uric Acid. A Systematic Review and Meta-Analysis

Wattanachayakul

Rujirachun

Charoenngam

et al. 2020

Advances in Respiratory Medicine

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“…A possible explanation given was that hypoxia in subjects with impaired pulmonary function can induce the production of uric acid. 11 Subjects with milder COPD (stages 1 and 2) were having lower uric acid than stages 3 and 4. An study from Egyptian journal of bronchology (EJB) showed median range of uric acid for severe and very severe disease as 7.6 mg/dL and 7.9 mg/dL respectively.…”

Section: Discussionmentioning

confidence: 95%

“…In the similar study, Rajlaxmi et al, also revealed that nonsmokers had higher (p>0.05) uric acid level than smokers but contrary to their study, results were statistically significant (p <0.05). 11 This finding possibly suggests that smoking reduces the antioxidant property of uric acid in the upper airways leading to increase risk and/or severity of COPD.…”

Section: Discussionmentioning

confidence: 99%

Correlation of serum uric acid with severity of airflow limitation in the patients of chronic obstructive pulmonary disease

et al. 2020

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Background: Serum uric acid (sUA) levels were previously found to be correlated with hypoxic states. We aimed to determine the levels of sUA in COPD patients and to evaluate whether sUA level can be used as predictors of exacerbation risk and disease severity.Methods: This cross-sectional study included COPD patients and healthy controls. The sUA levels in each group were evaluated and their correlations with the study parameters were investigated. ROC analyses for exacerbation risk were reported.Results: The study included 106 COPD patients and 110 healthy controls. The mean sUA levels were significantly higher in patients with COPD compared to healthy controls (p<0.05). Mean sUA levels were compared with different stages of COPD according to GOLD criteria. Stage 4 COPD subjects had highest sUA levels compared to other stages. Statistically significant trend was observed for GOLD staging of disease (p<0.05). Surprisingly non-smokers were having higher uric acid level than smokers (p<0.05). The ROC analyses indicated that sUA levels can be useful in predicting exacerbation risk (AUC, 0.412) especially at higher cut-off values, but with low specificity.Conclusions: Study suggested that sUA levels increased in patients with COPD compared to healthy controls. At higher cut-off values sUA levels might be useful in predicting COPD exacerbation risk and disease severity. However, more prospective cohort studies with large number of participants are needed to further analyse the possible different prognostic roles of hyperuricemia.

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“…Hyperuricaemia has been implicated in the pathogenesis of several human diseases with systemic inflammation; notably gout, vascular diseases such as atherosclerosis, hypertension, metabolic syndrome, as well as in various malignancies such as cancer of lungs, hematological malignancies, etc., [10]. Importantly, serum uric acid has been proposed as a marker for impaired oxidative metabolism & systemic inflammation and an independent predictor of impaired prognosis in several processes such as congestive heart failure primary pulmonary hypertension & acute myocardial infarction [11].…”

Section: Introductionmentioning

confidence: 99%

Study of Serum Magnesium and Uric acid level in patients with acute exacerbations of Chronic Obstructive Pulmonary Disease

Deepa¹,

Chandan²,

Meera³

et al. 2019

SIJB

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Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality and is therefore a major public health concern. Acute exacerbations that compromise quality of life, accelerate a decline in respiratory functions, and increase cardiovascular risk during the course of COPD. Few studies have investigated the factors leading to exacerbations. Magnesium may have a role in maintaining disease stability in COPD patients. And serum uric acid has been proposed as a marker for impaired oxidative metabolism & systemic inflammation. A few data exist on the significance of serum uric acid& magnesium in patients with AECOPD. Thus, the aim of this study was to evaluate the possible role of serum uric acid& magnesium as a biomarker for the prediction of outcome of patients with AECOPD. Study population was taken from patients admitted to K.R Hospital& PK TB Hospital MMCRI, Mysore with acute exerbation of COPD aged between 18-60years of either sex. 4ml of fasting venous sample was collected from patients admitted with acute exacerbation of COPD serum was analyzed immediately for Uric acid and Magnesium. 35% of patient had hypomagnesaemia where as 55% of study subjects where normomagnesemic with mean SD of 1.7+0.8. The mean standard deviation of uric acid levels was 7.2+ 2.1. Present study showed hypomagnesaemia and hyperuricemia with increase in duration of disease, stage of the disease and duration of hospital stay. Hence the present study helps in assessing the factors responsible for frequent exacerbations and durations of stay in hospital associated in COPD patients.

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Serum Uric Acid in Chronic Obstructive Pulmonary Disease: A Hospital Based Case Control Study

Abstract: Serum uric acid is a simple, cost effective biochemical test which may be useful in risk stratification of subjects with newly diagnosed chronic obstructive pulmonary disease. Hyperuricaemia is associated with advance duration and stage of COPD.

Cited by 16 publications

References 21 publications

Chronic Obstructive Pulmonary Disease is Associated with a Higher Level of Serum Uric Acid. A Systematic Review and Meta-Analysis

Chronic Obstructive Pulmonary Disease is Associated with a Higher Level of Serum Uric Acid. A Systematic Review and Meta-Analysis

Correlation of serum uric acid with severity of airflow limitation in the patients of chronic obstructive pulmonary disease

Study of Serum Magnesium and Uric acid level in patients with acute exacerbations of Chronic Obstructive Pulmonary Disease

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