Serum Uric Acid Could Differentiate Acute Myocardial Infarction and Unstable Angina Pectoris in Hyperuricemic Acute Coronary Syndrome Patients

Hasić, Sabaheta; Kadić, Damira; Kiseljaković, Emina; Jadrić, Radivoj; Spahić, Emina

doi:10.5455/medarh.2017.71.115-118

Cited by 14 publications

(10 citation statements)

References 24 publications

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“…Mean value of SUA were higher in ACS with its severity undergoing different stages as NSTEMI, STEMI as compared to UA group with less SUA. This result also shows MI patients have higher SUA level than that of UA which is similar to the study by Hasic et al [16] which shows levels of SUA are associated with the type of ACS in the hyperuricemic ACS patients (MI versus UA, 499(458-590) µmol/L, 425(400-447) µmol/L respectively with P value = 0.007. Our result also shows significant association between SUA and ACS.…”

Section: Discussionsupporting

confidence: 89%

Study of Serum Uric Acid Level in Acute Coronary Syndrome

Karki¹,

Rokaya²,

Khatri³

et al. 2019

TJSR

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At present, cardiovascular diseases are global health problems responsible for 17.3 million deaths per year and adding extra burden in developing countries like Nepal. Studies show that serum uric acid (SUA) can result in endothelial dysfunction which can lead to vascular disease like stroke. In this study, we determined serum uric acid levels in patients with acute coronary syndrome (ACS) and assess its risk factors. A cross sectional study was conducted in 82 patients with ACS who fulfilled the inclusion criteria included in the study and their serum uric acid level were investigated. It was found that 51 (62.2%) were males and 31 (37.8%) were females. Mean age in study population was 60.26 ± 11.34 years. Majority of the population belongs to 56-65 years age group. The mean uric acid level of our study population was 6.03 ± 1.50 mg/dl (male = 5.92 ± 1.72, female = 6.64 ± 1.53). SUA ≥ 7 mg/dl was maximum in 56-65 years age group and there was no association between age and SUA (P value = 0.146). Over half of the study population were hypertensive i.e. 42 (51.21%) and smoker i.e. 43 (52.43%). It showed association between SUA and ACS (P value = 0.003). Among those having diabetes, maximum have SUA ≥ 7 mg/dl i.e. 17 (47.22%). Among those having high cholesterol level, male have higher incidence than female with no association between T. Cholesterol and gender (P value = 0.49). The mean value of T. Cholesterol was 189.83 ± 46.81 mg/dl (male = 198.78 ± 55.19 mg/dl, female = 202.30 ± 54.92 mg/dl) with (P value = 0.52). In conclusion, the mean age of ACS patients was 60.26 years, with the peak incidence at the age of 56-65 years. The ACS had male predominance. The potential risk factors of ACS were: Age >56 years (65.83%), male sex (62.2%), dyslipidemia (35.36%, hypertension (51.2%), diabetes mellitus (43.9%), smoking (52.4%) and alcohol consumption (39%). Among these SUA significantly associated with risk factors were-Sex, Diabetes Mellitus, T. Cholesterol. There was association between serum uric acid level and ACS patients. Hypertension and smoking constitutes one of the major risk factor for ACS in study population.

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Section: Discussionsupporting

confidence: 89%

Study of Serum Uric Acid Level in Acute Coronary Syndrome

Karki¹,

Rokaya²,

Khatri³

et al. 2019

TJSR

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“…A strong positive correlation was obtained (Pearson correlation 0.807, P value <0.00001), that is, as the value of one increases the other also increases. Hasic et al 17 In the present study when serum uric acid level on the day of admission was correlated with ejection fraction (%). A strong negative correlation was obtained (Pearson correlation -0.827, p value <0.00001).…”

Section: Discussionsupporting

confidence: 45%

Understanding the Role of Serum Uric Acid as a Prognostic Marker in Acute Coronary Syndrome: A Hospital Based Study

Thakur¹,

Bhattacharjee²,

Das³

2018

jebmh

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BACKGROUNDCoronary artery disease remains the dominating cause of death in the world. Despite understanding and controlling the known risk factors for coronary artery disease, it remains the worldwide epidemic. This raises the possibility of the presence of unknown or underestimated risk factors. The role of uric acid as a prognostic factor in patients with acute coronary syndrome is controversial. The aim of the present study is to estimate serum uric acid levels in acute coronary syndrome and its correlation with Killip's classification of heart failure and in hospital mortality.

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“…cTnI, CK-MB and hs-CRP are sensitive factors to myocardial injury. cTnI has been reported to have a high sensitivity to myocardial infarction, however, due to its insignificant changes in the early stage of ACS, it can only be used to evaluate the severity of myocardial infarction ( 20 ). Similarly, although highly sensitive to myocardial infarction, CK-MB has poor specificity for myocardial injury because it is also increased in patients with diabetes and skeletal muscle trauma ( 21 ).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value and prognostic significance of CTRP9 combined with pentraxin‑3 in acute coronary syndrome

et al. 2021

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The present study aimed to explore the diagnostic value and prognostic significance of C1q/tumor necrosis factor-related protein 9 (CTRP9) combined with pentraxin-3 (PTX-3) in acute coronary syndrome (ACS). A total of 137 patients with coronary heart disease and chest pain were included. Among them, seventy-nine patients with ACS were allocated into a study group and fifty-eight patients with non-cardiac chest pain (NCCP) were allocated into a control group. The serum CTRP9, PTX-3 levels were quantified by ELISA, and their correlation with other ACS-related indexes, diagnostic value for ACS and predictive significance for poor prognosis were analyzed. In addition, the risk factors of the poor prognosis of ACS patients were studied. CTRP9 was lowly expressed and PTX-3 was highly expressed in the serum of ACS patients. CTRP9 was negatively correlated with cardiac troponin I (cTnI), creatine kinase-MB (CK-MB) and high-sensitivity C-reactive protein (hs-CRP) (P<0.05), while PTX-3 was positively correlated with them (P<0.05). Combined detection of CTRP9 and PTX-3 was of high value in the diagnosis and prognosis of ACS patients. In addition, CTRP9 and PTX-3 were independent risk factors for the poor prognosis of ACS. Patients with ACS had lower CTRP9 expression and higher PTX-3 expression than those without ACS. Moreover, the combined detection of CTRP9 and PTX-3 can better evaluate the diagnosis and prognosis of ACS patients.

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Serum Uric Acid Could Differentiate Acute Myocardial Infarction and Unstable Angina Pectoris in Hyperuricemic Acute Coronary Syndrome Patients

Cited by 14 publications

References 24 publications

Study of Serum Uric Acid Level in Acute Coronary Syndrome

Study of Serum Uric Acid Level in Acute Coronary Syndrome

Understanding the Role of Serum Uric Acid as a Prognostic Marker in Acute Coronary Syndrome: A Hospital Based Study

Diagnostic value and prognostic significance of CTRP9 combined with pentraxin‑3 in acute coronary syndrome

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