Serum Uric Acid concentration is associated with insulin resistance and impaired insulin secretion in adults at risk for Type 2 Diabetes

Martínez-Sánchez, Froylán David; Vargas-Abonce, Valerie Paola; Guerrero-Castillo, Anna Paula; Santos-Villavicencio, Manuel De los; Eseiza-Acevedo, Jocelyn; Meza-Arana, Clara Elena; Gulı́as-Herrero, Alfonso; Gómez-Sámano, Miguel Ángel

doi:10.1016/j.pcd.2020.10.006

Cited by 23 publications

(23 citation statements)

References 34 publications

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“…Another study has shown that even in subjects at risk for T2DM, SUA concentrations were significantly associated with impaired IR and insulin secretion. 22 IR is the common factor in many pathological and physiological conditions, including obesity, dyslipidemia, T2DM, abnormal glucose tolerance, hypertension and arteriosclerosis, and is a prevalent phenomenon in human disease. 23 IR can be present up to 20 years before the onset of T2DM, and in patients without diabetes, it has been an independent predictor of cardiovascular disease and mortality.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Four Non-Insulin-Based Indexes of Insulin Resistance and Serum Uric Acid in Patients with Type 2 Diabetes: A Cross-Sectional Study

Han¹,

Zhang²,

Jiang³

2022

DMSO

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Aim The aim of this study was to investigate the association between serum uric acid (SUA) levels and four insulin resistance surrogates in patients with type 2 diabetes (T2DM). The four non-insulin-based indexes of insulin resistance (IR) include the glucose and triglycerides index (TyG), TyG index with body mass index (TyG-BMI), ratio of triglycerides to high-density lipoprotein cholesterol (TG/HDL-c) and metabolic score for insulin resistance (METS-IR). Methods A total of 687 patients with T2DM were enrolled in the current study. Patients were stratified into three groups according to their levels of SUA. Spearman correlation was used to analyze the correlation between SUA and clinical variables. Multiple linear regression analysis was used to assess the association between SUA and the four insulin resistance surrogates. Receiver operating characteristic (ROC) analyses and the area under the ROC curve (AUC) were then used to assess the ability of TyG, TyG-BMI, TG/HDL-c, and METS-IR to discriminate hyperuricemia (HUA) in T2DM. Results SUA in T2DM was significantly positively correlated with TyG (r 0.406 P < 0.01), TyG-BMI (r 0.272 P < 0.01), TG/HDL-c (r 0.493 P < 0.01), and METS-IR (r 0.238 P < 0.01). Furthermore, higher values of the four insulin resistance surrogates were independently correlated with higher SUA levels in T2DM patients (P < 0.01 for all) after adjusting for confounding factors. TyG, TyG-BMI, TG/HDL-c, and METS-IR all had a significant discriminative ability for HUA in patients with T2DM. The AUC values were 0.693 (95% CI 0.645–0.741), 0.649 (95% CI 0.599–0.699), 0.768 (95% CI 0.726–0.811), and 0.660 (95% CI 0.609–0.710), respectively. Conclusion The present study suggests that TyG, TyG-BMI, TG/HDL-c and METS-IR had a significant correlation with SUA in T2DM. TG/HDL-c was the best marker among the four insulin resistance surrogates for the identification of HUA in T2DM.

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Section: Discussionmentioning

confidence: 99%

Relationship Between Four Non-Insulin-Based Indexes of Insulin Resistance and Serum Uric Acid in Patients with Type 2 Diabetes: A Cross-Sectional Study

Han¹,

Zhang²,

Jiang³

2022

DMSO

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“…Certain studies suggest a positive correlation between elevated serum UA levels and diabetes, whereas other reports are neutral or negative correlations. [ 1 5 6 39 ] We observed a statistically significant increment of HbA1c and FBS across the serum UA quartiles. In our study population, the prediabetic group had the maximum UA levels followed by the non-diabetic and diabetic group, which may indicate that the high UA levels may accelerate the development of diabetes or the high UA level has a role in the pathogenesis of diabetes.…”

Section: Discussionmentioning

confidence: 76%

“…Several ingestions have been carried out in different populations to assess the prevalence of serum UA in different groups and establish whether an association exists between serum UA with various chronic diseases. [ 2 3 4 5 6 7 8 9 10 ] It has been reported that serum UA content >6.57 mg/dL increases the risk of all-cause mortality. [ 11 ] It has been reported that elevated serum UA is associated with cardiovascular disease, hypertension, and chronic kidney disease.…”

Section: Introductionmentioning

confidence: 99%

“…[ 21 ] A serum UA content >6.57 mg/dL increases the risk of all-cause mortality. [ 5 ] Moreover, serum UA levels have been linked to glucose intolerance, obesity, and diabetes. [ 5 ] Therefore, we aimed to investigate the association between serum UA with diabetes and other critical biochemical parameters in the Asir region of Saudi Arabia.…”

Section: Introductionmentioning

confidence: 99%

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Association between serum uric acid with diabetes and other biochemical markers

Alasmary

Alqahtani

Awan³

et al. 2022

Journal of Family Medicine and Primary Care

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Objective: This study aimed to decipher the association between serum uric acid (UA) and glycated hemoglobin (HbA1c) in the population from the southern region of Saudi Arabia. Method: In this retrospective cross-sectional investigation, clinical data obtained from the different commercial laboratories in the Asir region of Saudi Arabia were screened over 2 years. Data were analyzed using standard statistical methods. Results: A total of 1984 laboratory investigations with 1215 females (61.2%) and 769 males (38.6%) were included in the data analysis. In our investigation, the prevalence of hyperuricemia in the study population was 53.5% (41.2% females and 12.3% males) and in the diabetic population was 12.7% (9.47% females and 3.23% males), in prediabetics was 12.65% (9.8% females and 2.85% males), respectively. Prediabetic subjects had higher UA levels than people with diabetes or healthy people. Higher UA quartiles were associated with a high level of urea, blood urea nitrogen (BUN) creatinine, HbA1c, fasting blood sugar (FBS), and total cholesterol (TC) ( P < 0.05). High UA (OR = 1.33 for diabetes; OR = 2.676 for prediabetes), high BUN (OR = 3.05 for diabetes; OR = 2.293 for prediabetes), high TC (OR = 3.75 for diabetes; OR = 1.098 for prediabetes), and high TG (OR = 2.67 for diabetes; OR = 1.943 for prediabetes) parameters are the most influential risk factor in diabetic and prediabetic patients than the people who have normal UA, BUN, TC, and TG value. Conclusion: High UA levels are significantly associated with prediabetes as defined by HbA1c criteria, indicating that UA has a significant role in the disturbance of glucose metabolism. A significant positive association was observed between dyslipidemia and serum UA in the study population.

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“…T2D model KK-A y /Ta mice have been found to show hyperuricemia as well as hyperglycemia [ 92 ], and taxifolin was demonstrated to suppress these spontaneous hyperuricemia and hyperglycemia, and hence an index of IR such as homeostasis model assessment of insulin resistance (HOMA-IR) [ 93 ], as well as purine bodies-induced hyperuricemia [ 94 ]. Recently, human serum uric acid concentration was shown to be associated with IR in adults as risk for T2D [ 95 ]. Thus, it is of interest to know whether or not aspalathin has the potential to suppress the spontaneous hyperuricemia in T2D model KK-A y /Ta mice as an animal model of preclinical trial [ 92 ].…”

Section: The Therapeutic Potential Of Aspalathin and Related Compounds In Targets For Diabetes From Recent Literaturementioning

confidence: 99%

New Insights into the Efficacy of Aspalathin and Other Related Phytochemicals in Type 2 Diabetes—A Review

Muller

Joubert

Chellan

et al. 2021

IJMS

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In the pursuit of bioactive phytochemicals as a therapeutic strategy to manage metabolic risk factors for type 2 diabetes (T2D), aspalathin, C-glucosyl dihydrochalcone from rooibos (Aspalathus linearis), has received much attention, along with its C-glucosyl flavone derivatives and phlorizin, the apple O-glucosyl dihydrochalcone well-known for its antidiabetic properties. We provided context for dietary exposure by highlighting dietary sources, compound stability during processing, bioavailability and microbial biotransformation. The review covered the role of these compounds in attenuating insulin resistance and enhancing glucose metabolism, alleviating gut dysbiosis and associated oxidative stress and inflammation, and hyperuricemia associated with T2D, focusing largely on the literature of the past 5 years. A key focus of this review was on emerging targets in the management of T2D, as highlighted in the recent literature, including enhancing of the insulin receptor and insulin receptor substrate 1 signaling via protein tyrosine phosphatase inhibition, increasing glycolysis with suppression of gluconeogenesis by sirtuin modulation, and reducing renal glucose reabsorption via sodium-glucose co-transporter 2. We conclude that biotransformation in the gut is most likely responsible for enhancing therapeutic effects observed for the C-glycosyl parent compounds, including aspalathin, and that these compounds and their derivatives have the potential to regulate multiple factors associated with the development and progression of T2D.

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Serum Uric Acid concentration is associated with insulin resistance and impaired insulin secretion in adults at risk for Type 2 Diabetes

Cited by 23 publications

References 34 publications

Relationship Between Four Non-Insulin-Based Indexes of Insulin Resistance and Serum Uric Acid in Patients with Type 2 Diabetes: A Cross-Sectional Study

Relationship Between Four Non-Insulin-Based Indexes of Insulin Resistance and Serum Uric Acid in Patients with Type 2 Diabetes: A Cross-Sectional Study

Association between serum uric acid with diabetes and other biochemical markers

New Insights into the Efficacy of Aspalathin and Other Related Phytochemicals in Type 2 Diabetes—A Review

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