Serum uric acid concentration is associated with hypertensive retinopathy in hypertensive chinese adults

Abstract

BackgroundThis cross sectional investigation included 12,966 subjects with hypertension, a cohort of the China Stroke Primary Prevention Trial (CSPPT), a randomized, multicenter clinical trial. This study aimed to explore the correlation between serum uric acid (SUA) concentration and hypertensive retinopathy in hypertensive adults.MethodsDiagnosis of hypertensive retinopathy was determined by non-mydriatic fundus photography and classified with Keith-Wagener-Barker (KWB) system. The correlation of SUA levels with hypertensive retinopathy prevalence and severity was assessed by statistical analysis.Results9848 (75.95%) subjects were diagnosed with hypertensive retinopathy with the following retinopathy grade distribution: grade 1: 58.80%, grade 2: 14.81%, and grade 3–4: 2.34%. SUA levels were significantly associated with hypertensive retinopathy prevalence. Patients with hypertensive retinopathy had higher SUA levels than those without hypertensive retinopathy. Patients in the highest uric acid quartile had an odds ratio for hypertensive retinopathy of 1.21 compared to patients in the lowest uric acid quartile (OR = 1.21, 95% CI: 1.05–1.40, P = 0.008). When compared to the non-hyperuricemia group, those in the hyperuricemia group had an odds ratio for hypertensive retinopathy of 1.18(OR = 1.18, 95% CI: 1.05–1.33, P = 0.004). Every 1 mg/dl increase in uric acid concentration was significantly associated with a 6% higher odds of hypertensive retinopathy (OR = 1.06, 95% CI: 1.02–1.10, P = 0.002).ConclusionsThe prevalence of hypertensive retinopathy was high (75.95%) among hypertensives in our patients cohort. In addition, SUA concentration was significantly associated with hypertensive retinopathy.

Increased of Serum IL-1β and MDA in Diabetic and Hypertensive Retinopathies

“…Uric acid crystal and ROS are able to activate inflammasome. It is reported that serum uric acid concentration is associated with hypertensive retinopathy in hypertensive Chinese adults [7]. Thus, ROS and MDA increased and the possible association between increased IL-β 1 and inflammasome activation in the eyes with systemic repercussion can be envisaged.…”

“…Chan & Zhu et al [5,6] in a review and meta-analysis study observed a significant association between gestational hypertensive disorders and development of retinopathy of prematurity. High serum level of uric acid correlated with the presence of hypertensive retinopathy [7], stroke, diastolic dysfunction and renal abnormality [8][9][10][11]. In spite of several studies on diabetic retinopathy, there are few reports in the literature comparing diabetic and hypertensive retinopathy.…”

Modern Aspects of Hypertensive Angioretinopathy

“…Миллионы людей в мире страдают от заболеваний, вызванных гипертонией [1]. Распространенность гипертонической ретинопатии составляет 75,95 % среди людей с гипертонической болезнью [2].…”

“…Chen и соавт. выявлена ключевая роль в возникновении гипертонической ретинопатии мочевой кислоты в высоких концентрациях в сыворотке крови [2]. Увеличение концентрации мочевой кислоты в 1 мг/дл достоверно ассоциировалось с гипертонической ретинопатией.…”

“…На основе статистического анализа оценивали корреляцию между уровнем мочевой кислоты в сыворотке крови и распространенностью и тяжестью гипертонической ретинопатии. Увеличение концентрации мочевой кислоты на 1 мг/дл достоверно увеличивало риск возникновения гипертонической ретинопатии на 6 % [2].…”