Serum uric acid change and modification of blood pressure and fasting plasma glucose in an overall healthy population sample: data from the Brisighella heart study

Cicero, Arrigo Francesco Giuseppe; Rosticci, Martina; Bove, Marilisa; Fogacci, Federica; Giovannini, Marina; Urso, R.; D’Addato, Sergio; Borghi, Claudio

doi:10.1080/07853890.2016.1222451

Cited by 58 publications

(38 citation statements)

References 34 publications

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“…However, this is the first study in which pre‐LT hyperuricemia is identified as a strong independent predictor of CV diseases among LT recipients. Among the general population, hyperuricemia is a recognized risk factor for CV events, including heart failure, and CV mortality, and importantly, uric acid–lowering agents have been shown to improve CV dysfunction and decrease the CV risk in the general population . This should be taken into account at the time of CV risk evaluation of candidates for LT and in the posttransplant management.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular morbidity and mortality after liver transplantation: The protective role of mycophenolate mofetil

et al. 2017

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Cardiovascular (CV) diseases are recognized longterm causes of death after liver transplantation (LT). The objective of this multicenter study was to analyze the prevalence and the evolution of CV risk factors and CV morbidity and mortality in 1819 LT recipients along 5 years after LT. The influence of baseline variables on survival, morbidity, and mortality was studied. There was a continuous and significant increase of the prevalence of all the CV risk factors (except smoking) after LT. CV diseases were the fourth cause of mortality in the 5 years after LT, causing 12% of deaths during the follow-up. Most CV events (39%) occurred in the first year after LT. Preexisting CV risk factors such as age, pre-LT CV events, diabetes, metabolic syndrome, and hyperuricemia, and mycophenolate-free immunosuppressive therapy, increased post-LT CV morbidity and mortality. The development of new-onset CV risk factors after LT, such as dyslipidemia and obesity, independently affected late CV morbidity and mortality. Tacrolimus and steroids increased the risk of posttransplant diabetes, whereas cyclosporine increased the risk of arterial hypertension, dyslipidemia, and metabolic syndrome. In conclusion, CV complications and CV mortality are frequent in LT recipients. Preexisting CV risk factors, immunosuppressive drugs, but also the early new onset of obesity and dyslipidemia after LT play an important role on late CV complications. A strict metabolic control in the immediate post-LT period is advisable for improving CV risk of LT recipients. Liver Transplantation 23 498-509 2017 AASLD.

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Section: Discussionmentioning

confidence: 99%

Cardiovascular morbidity and mortality after liver transplantation: The protective role of mycophenolate mofetil

et al. 2017

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“…Here, the increase in blood UA levels in the general population has been associated with increased incidence of hypertension and diabetes [109], LDL oxidation [110], arterial stiffness [111], impaired cognitive function [112], and heart failure [113]. …”

Section: Evidence From Clinical Studies Relevance For Humansmentioning

confidence: 99%

Fructose Intake, Serum Uric Acid, and Cardiometabolic Disorders: A Critical Review

et al. 2017

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There is a direct relationship between fructose intake and serum levels of uric acid (UA), which is the final product of purine metabolism. Recent preclinical and clinical evidence suggests that chronic hyperuricemia is an independent risk factor for hypertension, metabolic syndrome, and cardiovascular disease. It is probably also an independent risk factor for chronic kidney disease, Type 2 diabetes, and cognitive decline. These relationships have been observed for high serum UA levels (>5.5 mg/dL in women and >6 mg/dL in men), but also for normal to high serum UA levels (5–6 mg/dL). In this regard, blood UA levels are much higher in industrialized countries than in the rest of the world. Xanthine-oxidase inhibitors can reduce UA and seem to minimize its negative effects on vascular health. Other dietary and pathophysiological factors are also related to UA production. However, the role of fructose-derived UA in the pathogenesis of cardiometabolic disorders has not yet been fully clarified. Here, we critically review recent research on the biochemistry of UA production, the relationship between fructose intake and UA production, and how this relationship is linked to cardiometabolic disorders.

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“…Uric acid has proven emerging roles in various diseases such as gout, renal dysfunction, hypertension, hyperlipidemia, diabetes and obesity [4–7]. Hyperuricemia occurs as a result of the abnormal increased uric acid production and/or the impaired renal uric acid excretion [8].…”

Section: Introductionmentioning

confidence: 99%

Fasting plasma glucose and serum uric acid levels in a general Chinese population with normal glucose tolerance: A U-shaped curve

et al. 2017

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ObjectiveAlthough several epidemiological studies assessed the relationship between fasting plasma glucose (FPG) and serum uric acid (SUA) levels, the results were inconsistent. A cross-sectional study was conducted to investigate this relationship in Chinese individuals with normal glucose tolerance.Research design and methodsA total of 5,726 women and 5,457 men with normal glucose tolerance were enrolled in the study. All subjects underwent a 75-g oral glucose tolerance test. Generalized additive models and two-piecewise linear regression models were applied to assess the relationship.ResultsA U-shaped relationship between FPG and SUA was observed. After adjusting for potential confounders, the inflection points of FPG levels in the curves were 4.6 mmol/L in women and 4.7 mmol/L in men respectively. SUA levels decreased with increasing fasting plasma glucose concentrations before the inflection points (regression coefficient [β] = -36.4, P < 0.001 for women; β = -33.5, P < 0.001 for men), then SUA levels increased (β = 17.8, P < 0.001 for women; β = 13.9, P < 0.001 for men). Additionally, serum insulin levels were positively associated with FPG and SUA (P < 0.05).ConclusionsA U-shaped relationship between FPG and SUA levels existed in Chinese individuals with normal glucose tolerance. The association is partly mediated through serum insulin levels.

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Serum uric acid change and modification of blood pressure and fasting plasma glucose in an overall healthy population sample: data from the Brisighella heart study

Cited by 58 publications

References 34 publications

Cardiovascular morbidity and mortality after liver transplantation: The protective role of mycophenolate mofetil

Cardiovascular morbidity and mortality after liver transplantation: The protective role of mycophenolate mofetil

Fructose Intake, Serum Uric Acid, and Cardiometabolic Disorders: A Critical Review

Fasting plasma glucose and serum uric acid levels in a general Chinese population with normal glucose tolerance: A U-shaped curve

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