Serum Uric Acid As An Independent Predictor of Cardiovascular Event In Patients With Acute ST Elevation Myocardial Infarction

Dharma, Surya; Siswanto, Bambang Budi

doi:10.4172/2155-9880.s5-005

Cited by 8 publications

(11 citation statements)

References 20 publications

(18 reference statements)

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“…They found that STEMI patients with higher uric acid levels (>7.3 mg/dL) had increased rate of cardiovascular events compared with lower uric acid levels (<4.8 mg/dL). 45 Framingham Heart Study found no significant association between SUA levels with CVD in either men or women after adjustment for other risk factors and diuretic use. 27 Poullis suggested that the association of serum uric acid level with myocardial infarction, left ventricular dysfunction, and elevated inflammatory markers must be interpreted as an association, not a causal relation.…”

Section: Discussionmentioning

confidence: 92%

Admission Serum Uric Acid Levels and In-Hospital Outcomes in Patients with Acute Coronary Syndrome

Abdullah

Begum²,

Khan³

et al. 2015

J Enam Med Col

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Background: Uric acid is an independent risk factor for cardiovascular disease. Hospital admission for ischemic heart disease (IHD) is increasing rapidly in our country. Although studies were conducted abroad regarding association of serum uric acid with in-hospital outcomes in patients with acute coronary syndrome (ACS), no data is yet available to show the association in our country. Objective: The objective of this study was to assess the association of serum uric acid level on admission with in-hospital outcomes of the patients with ACS. Materials and Methods: This cross sectional comparative study was done in the Department of Cardiology, Dhaka Medical College Hospital (DMCH) from January to December 2012. After proper ethical consideration total 93 ACS patients were enrolled in the study by nonrandom sampling. Serum uric acid of all subjects was measured within 24 hours of admission. Then in-hospital outcomes were observed in all subjects. Results: The frequency of hyperuricemia among ACS patients was 24.7% (22.54% in male and 31.82% in female). Hyperuricemic patients significantly developed heart failure (30.4% vs 11.4%, p=0.032) and conduction defect (13.0% vs 1.4%, p=0.017) than normouricemic subjects. The mean ejection fraction was significantly lower in hyperuricemic patients than patients with normal uric acid level (50.87 ± 10.27% vs 55.94 ± 6.66%). The mean ± SD duration of hospital stay of hyperuricemic group was significantly longer in patients with ACS (8.26 ± 1.18 vs 7.51±1.18 days, p=0.010). Conclusion: The measurement of serum uric acid level, an easily available and inexpensive biochemical tool, might turn out as a valuable risk marker for prediction of in-hospital outcomes in patients with ACS. DOI: http://dx.doi.org/10.3329/jemc.v5i1.21492 J Enam Med Col 2015; 5(1): 15-22

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Section: Discussionmentioning

confidence: 92%

Admission Serum Uric Acid Levels and In-Hospital Outcomes in Patients with Acute Coronary Syndrome

Abdullah

Begum²,

Khan³

et al. 2015

J Enam Med Col

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“…Sarma et al 21 found hyperuricaemia (>6mg/dl) in 68.5% of CAD. A lower prevalence of hyperuricemia was observed by Keya et al 22 , Dharma et al 17 and Ndrepepa et al .23 In this study, acute LVF 10(24.4%) was in high serum uric acid level patients, and 7(9.5%) was in normal serum uric acid level patients. Acute LVF was significantly higher in high serum uric acid level than normal serum uric acid level patients (p=0.031).…”

Section: Discussionmentioning

confidence: 38%

Serum Uric Acid as a Prognostic Factor of Acute Myocardial Infarction in Hospitalized Patients

Sardar

Rahman

Alam

et al. 2021

TAJ: J of Teachers Assoc

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Background: Among non-communicable diseases, acute myocardial infarction (AMI) is a common killer of people in the world. The management of AMI patients is one of the major challenges in the field of cardiology. Uric acid has several effects of potential interest in cardiovascular disease. There are some markers indicating an unfavorable prognosis in AMI patients. Uric acid is one of the markers that have been evaluated in research. Objective: The aim of this study was to assess the association between serum uric acid level and in-hospital outcomes of AMI patients. Patients and methods: This longitudinal descriptive study was conducted over 115 AMI patients in the Cardiology Unit of Rajshahi Medical College Hospital during the period of January 2015 to December 2016. Baseline characteristics such as age, sex, BMI, BP, RBS, risk factors (hypertension, DM, smoking, family history of IHD, dyslipidemia), and outcomes of AMI patients (acute LVF, arrhythmia, conduction block, cardiogenic shock, death) were recorded. We measured the serum uric acid of this patient at admission. Results: The mean age of patients was 52.83±10.71 years. Out of 115 patients, 83.5% were male, and 16.5% were female. Among the risk factors, 65.2% of patients had HTN, 20.9% DM, 64.3% smoking, 16.5% family history of IHD, and 47.8% dyslipidemia. Out of 115, 35.7% of patients demonstrated high serum uric acid. In outcomes of AMI patients, acute LVF 24.4% (p=0.031) and death 12.2% (p=0.041) were significantly higher in patients with high serum uric acid levels. Conclusion: Significant association was found between high serum uric acid level and in-hospital outcomes of AMI patients. So, estimation of serum uric acid may offer an inexpensive, quick, and non-invasive method for identifying such high-risk patients. TAJ 2021; 34: No-1: 26-32

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“…12,13,14 Two theories are in existence regarding the role of uric acid; 1) It is a by-product from the lysosomal degradation of glycoprotein-urate complexes and binds with the lysosomal membrane via hydrogen bond causing membrane lysis. 15 2) Mediator of inflammation through the direct activation of the complement factors, free radical injury of the vessel wall. 16 Elevated uric acid is linked with obesity, 17 hypertension, 18 male gender.…”

Section: Discussionmentioning

confidence: 99%

Role of Serum Bilirubin as a Marker of Coronary Artery Disease

Nagula¹,

Yerrabandi²,

Otikunta³

et al. 2016

jebmh

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BACKGROUND Serum bilirubin is having protective effect as an antioxidant with capacity to remove reactive species of oxygen. Studies have suggested that an increased bilirubin level promotes protection against atherosclerosis. We have evaluated the level of serum bilirubin in patients with suspected coronary artery disease and its correlation with severity of lesion as assessed by modified Gensini score on angiography. MATERIALS AND METHODS A total of 540 patients have been enrolled in the study. Patients with diagnosis of acute coronary syndrome, stable angina, history of typical angina, Treadmill test positive were enrolled in the study. All patients were confirmed to have normal liver and renal function and were taken written consent for coronary angiography. The severity of lesion on angiography was assessed by modified Gensini score. Based on angiography results, the patients have been divided into CAD and control group. RESULTS The no. of patients in CAD group were (n=380) and control group were (n=160). Mean age of presentation in CAD group was 51.40±10.31 yrs. compared to controls 49.80±10.01 yrs. (p=0.1). Males were 70.26% in CAD group and 62.5% in controls (p = 0.08). The serum bilirubin was significantly lower in cases than in controls (0.56±0.28 mg/dL vs. 0.79±0.30 mg/dL, p <0.0001). There was a significant difference between other parameters assessed, i.e. RDW CV (14.46±0.74 vs. 13.72±0.85, p <0.0001), RDW SD (45.61±4.42 vs. 44.41±5.68, p = 0.0086), serum uric acid (7.10±2.06 mg/dL vs. 5.96±1.96 mg/dL, p <0.0001). Univariate analysis have been done followed by multivariate logistic regression analysis for assessing the independent risk factors for CAD. Serum bilirubin, RDW, Sex, Age and Diabetes were found to be independent predictors of presence of CAD. Serum bilirubin negatively correlated with presence of CAD (n=540, r=-0.46, p<0.0001). The cutoff value of serum bilirubin based on Receiver Operating Characteristic curve (ROC) analysis was 0.52 mg/dL for presence or absence of CAD with sensitivity of 80.3% and specificity of 89.1%. The correlation of low bilirubin with severity of CAD was (n=380, r=-0.34). The low serum bilirubin in smokers compared to nonsmokers (both in cases and control groups) did not attain statistical significance. The effect of smoking on level of bilirubin was minimal. CONCLUSION Low Serum bilirubin predicts the presence of CAD and is negatively correlated with the severity of CAD.

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Serum Uric Acid As An Independent Predictor of Cardiovascular Event In Patients With Acute ST Elevation Myocardial Infarction

Cited by 8 publications

References 20 publications

Admission Serum Uric Acid Levels and In-Hospital Outcomes in Patients with Acute Coronary Syndrome

Admission Serum Uric Acid Levels and In-Hospital Outcomes in Patients with Acute Coronary Syndrome

Serum Uric Acid as a Prognostic Factor of Acute Myocardial Infarction in Hospitalized Patients

Role of Serum Bilirubin as a Marker of Coronary Artery Disease

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