Serum Uric Acid as a Potential Concomitant with  Carotid Atherosclerosis

Roudbary, Seyed-Ali; Alizadeh, Ahmad; Ghayeghran, Amirreza; Roshan, Fariborz

doi:10.18869/acadpub.cjns.2.6.33

Cited by 1 publication

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“…Preventive factors are smoking, low socioeconomic status (SES), hypertension (HTN), dyslipidemia, hyperuricemia, cardiovascular disorders, carotid artery diseases, and obesity. [4][5][6][7] Some of the abovementioned risk factors have role on prognosis and also hospitalization period which are responsible for a part of cost and economic burden of stroke. 8 The major drugs abused in Iran are opium and its byproducts.…”

Section: Introductionmentioning

confidence: 99%

Cerebral hemodynamic abnormalities of patients with ischemic stroke who are opium addicted: A study by transcranial doppler ultrasonography

Moadabi

Saberi

Hoseini

et al. 2019

CJN

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Background: Ischemic stroke as the major cause of mortality and morbidity worldwide has different risk factors. One of its modifiable risk factors is opium addiction whose role is not clear yet. This study aimed at assessing the hemodynamic parameters in ischemic stroke patients addicted to opium using transcranial Doppler (TCD) ultrasonography and comparing them with non-addicted patients. Methods: This comparative cross-sectional study was conducted in an academic hospital in the north of Iran in 2016. All the patients diagnosed as ischemic stroke underwent cerebrovascular ultrasound in the first 4 days of symptoms onset. Frequency of hemodynamic abnormalities confirmed by pulsatility index (PI) and mean flow velocity (MFV) were determined and compared between the two groups. The data were analyzed by chi-square test, t-test, and multiple logistic regression models using SPSS software. Results: A total of 353 patients with ischemic stroke (92 addicted and 261 non-addicted patients) were enrolled in the study. Univariate analysis indicated that the PI and MFV differences were statistically significant between two groups of addicted and nonaddicted patients (P = 0.0001). By multivariate logistic regression model, the age [odds ratio (OR) = 1.143], diabetes mellitus (DM) (OR = 3.875), hypertension (HTN) (OR = 2.557), and opium usage (OR = 9.615) had influence on PI and only opium usage (OR = 3.246) had influence on MFV. Conclusion: Opium usage affects the cerebral hemodynamic parameters and increases the chance of having abnormal PI as ten-fold and abnormal MFV as three-fold.

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Section: Introductionmentioning

confidence: 99%