Serum Uric Acid and Risk of Cardiovascular Mortality: A Prospective Long-Term Study of 83 683 Austrian Men

Strasak, Alexander; Ruttmann, Elfriede; Brant, Larry J.; Kelleher, Cecily; Klenk, Jochen; Concin, Hans; Diem, Günter; Pfeiffer, Karl P.; Ulmer, Hanno

doi:10.1373/clinchem.2007.094425

Cited by 189 publications

(174 citation statements)

References 38 publications

(27 reference statements)

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“…This result was consistent with previous studies that the presence of MS conferred an increased UA [24,25]. Recently, several researchers have identified high levels of UA as an independent risk factor for the cardiovascular events [1,2], and one of our previous study demonstrated that serum uric acid correlated with left ventricular mass index independent of blood pressure [26]. Theoretically, several possible pathological mechanisms linking UA to cardiovascular disease have been proposed, including negative correlation with endothelial function while the relationship between uric acid and micro vascular dysfunction has been doubted [27].…”

Section: Discussionsupporting

confidence: 93%

“…Recently, several studies have indicated that uric acid (UA), the circulating end-metabolite of purine nucleotides of mankind, is associated with subsequent cardiovascular diseases [1,2]. However, it remains controversial whether UA is a relevant and independent risk factor for cardiovascular disease and the mechanisms by which UA results in target organ injury are still unknown.…”

Section: Instructionmentioning

confidence: 99%

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Relationship between Uric Acid and Endothelial Function in Hypertensive Patients with Metabolic Syndrome

Huang¹,

Cai²,

Zheng³

et al. 2016

J Clin Exp Cardiolog

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Aim: To investigate the association between uric acid (UA) and endothelial function in Chinese hypertensive patients with Metabolic Syndrome (MS).Methods: 615 hypertensive patients were enrolled, all hypertensives were divided into two groups: hypertensives with MS (MS group, n=239) and hypertensives without MS (NMS group, n=376). 87 age-and sex-matched normotensives served as controls (NC group). Flow-mediated (endothelium-dependent) dilatations (FMD), nitroglycerin-induced (endothelium-independent) dilatation (EID) in the brachial artery were assessed by highresolution ultrasonography. UA was detected by urease indophenol. .58)%, p<0.001) among groups. After stratification of gender, lower FMD was only seen in male hypertensives with MS accompanied by hyperuricemia <60 years old ((9.98 ± 5.78)% vs (7.12 ± 4.49)%, p<0.05); Pearson correlation analysis showed that the FMD was negatively correlated with UA (r=-0.314, p<0.01); Finally, logistic regression analysis showed that a 50 µmol/L increase in UA levels carried a 41.1% higher risk for endothelial dysfunction in this cohort. Conclusions: A higher UA level is related to poorer endothelial function in hypertensives with MS. Increased UA can be used as an alternative indicator for monitoring endothelial function and preventing vascular damage in male hypertensives with MS aged less than 60 years old.Keywords: Uric acid; Endothelial dysfunction; Hypertension; Metabolic syndrome InstructionRecently, several studies have indicated that uric acid (UA), the circulating end-metabolite of purine nucleotides of mankind, is associated with subsequent cardiovascular diseases [1,2]. However, it remains controversial whether UA is a relevant and independent risk factor for cardiovascular disease and the mechanisms by which UA results in target organ injury are still unknown. Increasing data suggest that UA is associated with endothelial dysfunction [3,4], which is characteristic of patients with essential hypertension [5]. It is well recognized that endothelial dysfunction is an early stage in atherogenesis and associates with poor cerebro-cardiovascular outcomes [6]. It has been shown that UA disturbs endothelial function by disrupting nitric oxide (NO) synthesis, inhibiting NO bioavailability and activating the renin-angiotensin system.Metabolic syndrome (MS) is believed to be a clustering of abnormalities of several cardiovascular risk factors in an individual including abdominal obesity, hypertension, and dyslipidemia, including low HDL-C, high LDL-C and hyperglycemia. MS is often associated with elevated UA levels [7] and endothelial dysfunction [8,9]. The prevalence of MS has been increasing in recent years in China. A recent epidemiological study showed that the prevalence of MS among Chinese men and women aged 35 to 64 years old was 9.8% and 17.8%, respectively [10]. As is known to all, MS is quite common in patients with primary hypertension and carries much higher risk of cardiovascular events. It was reported that nearly 90% of Chinese hypertensives were ...

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Section: Discussionsupporting

confidence: 93%

Section: Instructionmentioning

confidence: 99%

Relationship between Uric Acid and Endothelial Function in Hypertensive Patients with Metabolic Syndrome

Huang¹,

Cai²,

Zheng³

et al. 2016

J Clin Exp Cardiolog

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“…Similarly, Strasak et al [16] also observed a positive correlation between SUA and smoking (r = 0.11, P < 0.001). Mozos et al [17] also found that SUA levels were significantly higher in smokers as compared to non smokers (5.7 ± 1.3 vs. 5.0 ± 1.1 mg/dl, P < 0.05).…”

Section: Discussionmentioning

confidence: 60%

Serum Uric Acid Levels in Acute Ischemic Stroke: A Study of 100 Patients

Patil

2011

J Neurol Res

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“…12 Mozos et al also found that SUA levels were significantly higher in smokers as compared to nonsmokers (5.7±1.3 versus 5.0±1.1 mg/dl, P < 0.05).…”

mentioning

confidence: 83%

Serum uric acid level in acute ischemic stroke in eastern India

2017

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Background: Present study was done to estimate the level of serum uric acid in acute ischemic stroke and to find out whether it is protective against or increases the risk for ischemic stroke and its effect on stroke outcome.Methods: A total of 100 patients and 100 controls were taken randomly. Risk factors of stroke were considered such as hypertension, diabetes, adverse lipid profile, smoking and obesity. Serum uric acid level was measured in both cases and controls. Modified National Institute of Health (NIH) stroke scale score was calculated at the time of admission and discharge. Statistical analysis was done using SPSS 21.0 software.Results: Out of 100 patients studied 65 were males and 35 were females. The mean serum uric acid level in stroke cases was 6.11±1.47 where as it was 4.85±1.12 in controls. SUA levels was higher among males than females. The mean SUA in hypertensive subjects (6.58±1.33) was significantly higher than in normotensive subjects (5.23±1.42). There was statistically significant difference between SUA levels in diabetic (6.66±1.26) and non-diabetic patients (5.63±1.49). Mean SUA among overweight patients was (7.0±1.16) where as it was (5.22±1.23) in patients with normal weight. The mean SUA in smokers (6.33±1.38) was higher than that in non-smokers (6.02±1.51). There was significant positive correlation between SUA an NIH stroke scale score(P<0.05). SUA levels were significantly higher in patients who succumbed as compared to those who were discharged from hospital.Conclusions: SUA can be used as a marker for increased of stroke. Higher SUA is associated with a bad prognosis.

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Serum Uric Acid and Risk of Cardiovascular Mortality: A Prospective Long-Term Study of 83 683 Austrian Men

Cited by 189 publications

References 38 publications

Relationship between Uric Acid and Endothelial Function in Hypertensive Patients with Metabolic Syndrome

Relationship between Uric Acid and Endothelial Function in Hypertensive Patients with Metabolic Syndrome

Serum Uric Acid Levels in Acute Ischemic Stroke: A Study of 100 Patients

Serum uric acid level in acute ischemic stroke in eastern India

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