Serum Uric Acid and High-Sensitivity C-Reactive Protein as Predictors of Cognitive Impairment in Patients with Cerebral Infarction

Abstract

<b><i>Background:</i></b> Cognitive impairment induced by cerebral infarction has become a devastating health problem. More efficient predictors are required to evaluate the potential cognitive decline after cerebral infarction in clinic. Serum uric acid (UA) and high-sensitivity C-reactive protein (hs-CRP) are two factors reported to correlate with cognitive impairment. However, the understanding on serum UA and hs-CRP with cognitive dysfunction remains unclear. <b><i>Methods:</i></b> Serum UA and hs-CRP were evaluated in patients with cerebral infarction (<i>n</i> = 197) using single factor analysis and multivariate logistic regression analysis. Clinical and pathological characteristics were analyzed by logistic regression, respectively, and the results demonstrated the correlation between the pathological characteristics and the cognitive impairment post cerebral infarction. Montreal Cognitive Assessment (MoCA) was used to evaluate the patients’ cognitive function, and patients with a MoCA score <26 were recognized as with cognitive impairment. <b><i>Results:</i></b> Clinical characteristics related to cognitive impairment, including age, gender, blood pressure, serum UA, and hs-CRP were collected and analyzed. Serum UA and hs-CRP were identified to be potential predictors for post-stroke cognitive dysfunction, with higher serum UA levels correlated with better cognitive function and higher hs-CRP levels correlated with worse cognitive impairment. <b><i>Conclusion:</i></b> Serum UA and hs-CRP are two predictors for cognitive impairment post cerebral infarction.

Uric Acid and Cognitive Impairment in Patients with Acute Ischemic Stroke: A Meta-Analysis

“…Evaluation of cognitive function after AIS was performed during the hospitalization in six studies 20 22 24 25 26 27 , and during follow-up after discharge in the other five studies 21 23 28 29 30 . Diagnosis of PSCI was based on the Mini-mental State Examination (MMSE) in two studies 20 28 , the Montreal Cognitive Assessment (MoCA) in seven studies 21 22 24 25 26 29 30 , and MMSE or MoCA in one study 27 . The other study reported two datasets of serum UA values for PSCI diagnosed with MMSE and MoCA, separately 23 .…”

“…Five studies 25 26 27 29 30 with 2679 patients with AIS reported the risk of PSCI comparing between AIS patients with higher versus lower serum UA at admission. Pooled results showed that higher serum UA was associated with PSCI in patients with AIS (OR: 1.33, 95% CI: 1.02 to 1.73, p=0.04; I 2 =72%; Fig.…”

“…UA after AIS may be associated with PSCI [19]. However, results of previous studies comparing the serum level of US between patients with and without PSCI showed inconsistent results [20][21][22][23][24][25][26][27][28][29][30], and the association between serum UA and PSCI in patients with AIS remains to be determined. Therefore, in this study, we performed a meta-analysis to systematically evaluate the association between serum UA and PSCI in patients with AIS.…”

“…1. Finally, eleven observational studies [20][21][22][23][24][25][26][27][28][29][30] were available for the meta-analysis.…”

Diagnostic Values of Serum Levels of Homocysteine, Heat Shock Protein 70 and High-Sensitivity C-Reactive Protein for Predicting Vascular Cognitive Impairment

“… 41 CRP is an acute hepatic biomarker in systemic inflammation correlated with cognitive function. 42 It also demonstrated that higher concentrations of hs-CRP in patients led to cognitive dysfunction after cerebral infarction. 42 Therefore, it could be a potential clinical biomarker to evaluate the level of cognitive decline.…”