Serum uric acid and albumin are affected by different variables in Parkinson’s disease

Hemmati-Dinarvand, Mohsen; Niknam, Maryam; Vahed, Sepideh Zununi; Samadi, Nasser

doi:10.1007/s10072-018-3548-2

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…Meanwhile, albumin is a vital serological index reflecting the severity of inflammation (16,17). Studies have demonstrated that albumin is a negative acute phase protein (18), which can be utilized as a useful parameter to evaluate the mortality and prognosis of various diseases (19,20).…”

Section: Introductionmentioning

confidence: 99%

Elevated lactate/albumin ratio is associated with poor prognosis in sepsis patients: A systematic review and meta-analysis

Zhao,

Peng,

et al. 2024

J Med Biochemistry

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Background: The aim of this study was to explore the association between lactate/albumin ratio and the prognosis of sepsis patients. Methods: A computerized search was performed in Pubmed, EMbase, Ovid, Medline, and Google Scholar to collate relevant studies. The results were compared using standardized mean differences (SMD)/odds ratio (OR) and 95% confidence intervals (CI). Prospective and retrospective cohort studies were both included in this study. Results: A total of nine studies involving 3039 participants were included. Pooled analysis revealed that survivors had substantially lower lactate/albumin ratio than non-survivors (SMD=-2.02, 95% CI: -2.76 to -1.28, I2=97.4%). Further, our results also indicated that elevated lactate/albumin ratio is an independent risk factor for mortality (OR=2.16, 95% CI: 1.58 to 2.95, I2=76.2%) and multiple organ dysfunction syndrome (MODS) (OR=3.41, 95% CI: 1.78 to 6.50, I2=0.0%) in septic patients. Moreover, according to the area under curve (AUC) results, the lactate/albumin ratio also presented good discriminatory power to predict mortality (AUC=0.75, 95% CI: 0.68 to 0.84, I2=92.9%) and MODS (AUC=0.78, 95% CI: 0.68 to 0.91, I2=65.1%) in septic patients. Begg's and Egger's test suggested no publication bias in the included studies. Conclusions: Our results highlighted that the lactate/albumin ratio is an important prognostic factor for MODS and mortality in sepsis patients, having good capabilities in identifying MODS and mortality.

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Section: Introductionmentioning

confidence: 99%

Elevated lactate/albumin ratio is associated with poor prognosis in sepsis patients: A systematic review and meta-analysis

Zhao,

Peng,

et al. 2024

J Med Biochemistry

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“…2 HSA is the abundant protein carrier found in blood and is commonly used as an indicator for many diseases including diabetes and renal diseases. 3,4 GHSA has been suggested to be one of the potential diabetes biomarkers 5 since its level in blood can be used for diabetes screening and monitoring in medical practice. 6,7 GHSA detection can also be employed for patients with kidney and liver problems whose hemoglobin A1c level (which is a common diabetes biomarker) may be inaccurate.…”

Section: ■ Introductionmentioning

confidence: 99%

Structural and Dynamic Alteration of Glycated Human Serum Albumin in Schiff Base and Amadori Adducts: A Molecular Simulation Study

et al. 2023

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Human serum albumin (HSA) is a protein carrier in blood transporting metabolites and drugs. Glycated HSA (GHSA) acts as a potential biomarker for diabetes. Thus, many attempts have been made to detect GHSA. Glycation was reported to damage the structure and ligand binding capability, where no molecular detail is available. Recently, the crystal structure of GHSA has been solved, where two glucose isomers (pyranose/GLC and open-chain/GLO) are located at Sudlow’s site I. GLO was found to covalently bind to K195, while GLC is trapped by noncontact interactions. GHSA exists in two forms (Schiff base (SCH) and Amadori (AMA) adducts), but how both disrupt albumin activity microscopically remains unknown. To this end, molecular dynamics simulations were performed here to explore the nature of SCH and AMA. Both forms are found to alter the main protein dynamics, resulting in (i) the widening of Sudlow’s site I entrance, (ii) the size reduction of nine fatty acid-binding pockets, (iii) the enlargement of Sudlow’s site I and the shrinking of Sudlow’s site II, (iv) the enhancement of C34 reactivity, and (v) the change in the W214 microenvironment. These unique characteristics found here can be useful for understanding the effect of glycation on the albumin function in more detail and designing specific and selective GHSA detection strategies.

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Assessment of serum uric acid levels in patients with restless legs syndrome

Yazar

Yıldırım

et al. 2019

Acta Neurol Belg

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Serum uric acid and albumin are affected by different variables in Parkinson’s disease

Cited by 3 publications

References 13 publications

Elevated lactate/albumin ratio is associated with poor prognosis in sepsis patients: A systematic review and meta-analysis

Elevated lactate/albumin ratio is associated with poor prognosis in sepsis patients: A systematic review and meta-analysis

Structural and Dynamic Alteration of Glycated Human Serum Albumin in Schiff Base and Amadori Adducts: A Molecular Simulation Study

Assessment of serum uric acid levels in patients with restless legs syndrome

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