Serum uric acid and AKI: is it time?

Kaushik, Manish; Choo, Jason Chon Jun

doi:10.1093/ckj/sfv127

Cited by 12 publications

(11 citation statements)

References 27 publications

(29 reference statements)

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“…The biochemical and histopathological changes in the positive control group (kanamycin-treated rats) is in accordance to those described by other authors under similar conditions 27 , 28 . The increase in serum concentrations of uric acid and urea in this group indicates a decrease in the glomerular filtration rate, which constitutes a hallmark of AKI 29 - 31 , being the increase of urea in the Positive control group in agreement with values reported in diverse animal models of aminoglycoside-induced AKI 8 .…”

Section: Discussionsupporting

confidence: 88%

Benefits of D-005, a lipid extract from Acrocomia crispa fruits, in the prevention of acute kidney njury induced by nephrotoxicity in rats

et al. 2022

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Introduction: Aminoglycoside-induced acute kidney injury (AKI) is a pathology closely linked to oxidative and inflammatory reactions. Taking into account the previous reported antioxidant and anti-inflammatory effects of D-005, a lipid extract obtained from Cuban palm Acrocomia crispa (Arecaceae) fruits, this work aimed to evaluate the effects of D-005 on kanamycin-induced AKI. Methods: Male Wistar rats were divided into 7 groups: negative control (vehicle, Tween 65/H2O) and six groups treated with kanamycin to induce AKI: positive control (vehicle), D-005 (25, 100, 200, and 400 mg/kg) and grape seed extract (GSE, 200 mg/kg). D-005, vehicle, and GSE oral treatments were administered once daily for seven days, 1 h before kanamycin (500 mg/kg, i.p.). Serum uric acid and urea concentrations, renal histopathology, and oxidative markers (malondialdehyde (MDA), sulfhydryl (SH) groups, and catalase (CAT) activity) were assessed. Results: D-005 significantly reduced uric acid and urea levels, starting from D-005 100 mg/kg. Histopathologically, D-005, at all the tested doses, protected renal parenchyma structures (glomeruli, proximal tubules, and interstitium). These findings were accompanied by a significant reduction of MDA and SH group concentrations as well as restoration of CAT activity. The highest percentages of inhibition were obtained with the dose of 400 mg/kg. GSE, the reference substance, also prevented kanamycin-induced biochemical and histopathological changes, as well as reduced MDA and SH groups and restored CAT activity. Conclusion: The administration of repeated oral doses of D-005 significantly protected against kanamycin-induced AKI, which could be associated with the antioxidant and anti-inflammatory effects of this extract.

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Section: Discussionsupporting

confidence: 88%

Benefits of D-005, a lipid extract from Acrocomia crispa fruits, in the prevention of acute kidney njury induced by nephrotoxicity in rats

et al. 2022

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“…In another large study, hyperuricaemia was associated with a higher risk for in-hospital acute kidney injury (AKI) [13]. Various mechanisms attributed to hyperuricaemia-induced AKI include crystal precipitation in addition to various non-crystal mechanisms due to hyperuricaemia leading to AKI as described by Kaushik et al [14]. Acute kidney injury subsequently leads to a cascade of complications and finally affecting the outcome in a given case of sepsis.…”

Section: Discussionmentioning

confidence: 97%

Hyperuricaemia as a predictor of hospital outcome in patients with sepsis: results of a prospective study

et al. 2021

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Background Early management of sepsis in the emergency department improves patient outcomes. The identification of at-risk patients for aggressive management by an easily available biomarker could go a long way in the triage of patients in the emergency department. It is postulated that during sepsis, the majority of patients undergo ischaemic reperfusion injury or inflammation, and uric acid with its oxidant and antioxidant properties may be playing some role and, hence, the measurement of uric acid could possibly predict the hospital course in patients with sepsis. We were prompted to undertake this study as serum uric acid estimation is readily available and economical compared to newly evolving biomarkers in sepsis. Estimation of serum uric acid levels on arrival to the emergency department may prove a useful predictor of hospital outcome in patients with sepsis especially in regions with limited resources. Results Of 102 patients, 55 (53.9%) were males. The mean age of the study cohort was 63.2 ± 10.48. Patients with higher qSOFA scores had higher uric acid levels on admission. While 12 (11.8%) patients had a septicaemic shock, acute kidney injury was recorded in 48 (47.1%) patients and 11 (10.8%) patients required dialysis. Thirty-four (33.3%) patients had respiratory failure, and of these, 21 (20.6%) patients required mechanical ventilation. The overall median stay in the medical intensive care (MICU) was 3days (range 2–7 days). The patients with higher uric acid levels had higher rates of respiratory failure but did not reach significant levels. In 15 (14.7%) patients, 7 males expired (mortality rate of 14.7%). There was a significant association between SOFA score and mortality. Patients who succumbed to sepsis had higher serum uric acid levels on arrival. Conclusions Patients with higher qSOFA scores had higher uric acid levels on admission. Hyperuricaemia predicted acute kidney injury, a requirement of mechanical ventilation and mean hospital stay in patients with sepsis. Further studies may be required to confirm the association.

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“…As a traditional indicator, Scr has been widely applied in clinical practise to evaluate the renal function. Additionally, UA might promote inflammation, oxidative stress, mitochondrial dysfunction, and activate renin-angiotensin system to induce renal vasoconstriction and the impairment of renal vascular endothelium [ 26 , 27 ]. In this study, both these two typical biomarkers were the potential predictors for AKI risk.…”

Section: Discussionmentioning

confidence: 99%

Development of an acute kidney injury risk prediction model for patients undergoing extracorporeal membrane oxygenation

Wang¹,

Chen²,

Ni³

et al. 2022

Heliyon

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Serum uric acid and AKI: is it time?

Cited by 12 publications

References 27 publications

Benefits of D-005, a lipid extract from Acrocomia crispa fruits, in the prevention of acute kidney njury induced by nephrotoxicity in rats

Benefits of D-005, a lipid extract from Acrocomia crispa fruits, in the prevention of acute kidney njury induced by nephrotoxicity in rats

Hyperuricaemia as a predictor of hospital outcome in patients with sepsis: results of a prospective study

Development of an acute kidney injury risk prediction model for patients undergoing extracorporeal membrane oxygenation

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