Serum untargeted metabolomic profile of the Dietary Approaches to Stop Hypertension (DASH) dietary pattern

Rebholz, Casey M.; Lichtenstein, Alice H.; Zheng, Zihe; Appel, Lawrence J.; Coresh, Josef

doi:10.1093/ajcn/nqy099

Cited by 106 publications

(117 citation statements)

References 51 publications

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“…Moreover, hippurate was associated with lower risk of all-cause mortality, even when adjusting for traditional risk factors. N-methylproline was recently shown to associate with healthy eating, to be decreased after following the Dietary Approaches to Stop Hypertension (DASH) diet [23] and to associate with decreased risk of CAD and all-cause mortality in individuals free from CMD [24]. In concert with these previous findings, our study indicates that healthy eating, particularly intake of citrus fruit, is beneficial in individuals with diabetes.…”

Section: Discussionsupporting

confidence: 78%

Plasma Metabolites Associate with All-Cause Mortality in Individuals with Type 2 Diabetes

et al. 2020

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Alterations in the human metabolome occur years before clinical manifestation of type 2 diabetes (T2DM). By contrast, there is little knowledge of how metabolite alterations in individuals with diabetes relate to risk of diabetes complications and premature mortality. Metabolite profiling was performed using liquid chromatography-mass spectrometry in 743 participants with T2DM from the population-based prospective cohorts The Malmö Diet and Cancer-Cardiovascular Cohort (MDC-CC) and The Malmö Preventive Project (MPP). During follow-up, a total of 175 new-onset cases of cardiovascular disease (CVD) and 298 deaths occurred. Cox regressions were used to relate baseline levels of plasma metabolites to incident CVD and all-cause mortality. A total of 11 metabolites were significantly (false discovery rate (fdr) <0.05) associated with all-cause mortality. Acisoga, acylcarnitine C10:3, dimethylguanidino valerate, homocitrulline, N2,N2-dimethylguanosine, 1-methyladenosine and urobilin were associated with an increased risk, while hippurate, lysine, threonine and tryptophan were associated with a decreased risk. Ten out of 11 metabolites remained significantly associated after adjustments for cardiometabolic risk factors. The associations between metabolite levels and incident CVD were not as strong as for all-cause mortality, although 11 metabolites were nominally significant (p < 0.05). Further examination of the mortality-related metabolites may shed more light on the pathophysiology linking diabetes to premature mortality.

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Section: Discussionsupporting

confidence: 78%

Plasma Metabolites Associate with All-Cause Mortality in Individuals with Type 2 Diabetes

et al. 2020

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“…A large number of metabolites in the human circulation derive directly from the digestion and metabolism of food components and constitute the food metabolome 5. Both endogenous plasma metabolites and metabolites from the food metabolome have been shown to correlate with certain dietary patterns estimated using questionnaires on dietary intake in cohort studies,6 and with certain food items in randomised controlled feeding trials 7. The connection between diet and the metabolome is particularly interesting because circulating levels of specific metabolites have previously been shown to predict future risk of type 2 diabetes,8 CAD9 and premature mortality 10.…”

Section: Introductionmentioning

confidence: 99%

Ergothioneine is associated with reduced mortality and decreased risk of cardiovascular disease

Smith

Ottosson

Hellstrand

et al. 2019

Heart

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ObjectivesWe recently identified a health conscious food pattern (HCFP) associated with reduced risk of cardiometabolic disease. However, the molecular events linking the healthy food pattern to reduced risk of cardiometabolic disease are unknown. Our aim was to identify plasma metabolites associated with the HCFP and test if such metabolites predict cardiometabolic disease and mortality.MethodsUsing liquid-chromatography mass-spectrometry, 112 plasma metabolites were measured in 3236 participants without cardiovascular disease (CVD) and diabetes mellitus from the population-based Malmö Diet and Cancer study. Metabolites associated with the HCFP were identified using multivariable adjusted linear regressions followed by Bonferroni correction. The healthy dietary biomarkers were subsequently related to risk of cardiometabolic disease and mortality during long-term follow-up with multivariable adjusted Cox proportional hazards models.ResultsDuring a median follow-up time of 21.4 years, 603 participants developed CVD, 362 developed diabetes mellitus and 843 participants died. Five healthy dietary biomarkers were associated with the HCFP at baseline (p<0.0004) and four predicted at least one of the studied end points (p<0.05). Ergothioneine was the metabolite most strongly connected to the HCFP and was associated with a lower risk of coronary disease (HR per 1 SD increment of ergothioneine, HR=0.85, p=0.01), cardiovascular mortality (HR=0.79, p=0.002) and overall mortality (HR=0.86, p=4e-5).ConclusionsWe identified that higher ergothioneine was an independent marker of lower risk of cardiometabolic disease and mortality, which potentially can be induced by a specific healthy dietary intake.

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“…A subgroup of eight participants underwent the fourth intervention with white beans, which was scheduled later. The subjects were on average 28 ± 6 years old (range: [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] and had a BMI of 23.8 ± 3.6 kg m −2 (range: 18.6-28.9).…”

Section: Methodsmentioning

confidence: 99%

“…However, the complete clearance of its metabolism could not be estimated since this metabolite was still detected during the 24-48 h period, when the last sample was collected. It has been correlated with nut intake in different cross-sectional studies, [28][29][30][31] and it has also been associated with the Mediterranean diet [32] and the Dietary Approaches to Stop Hypertension [33] dietary patterns. Additionally, a study focused on peanut consumption also reported its presence in the breast milk of lactating women.…”

Section: Bfi For Legumesmentioning

confidence: 99%

Discovery of Intake Biomarkers of Lentils, Chickpeas, and White Beans by Untargeted LC–MS Metabolomics in Serum and Urine

Ulaszewska¹,

Franceschi

Estruel-Amades

et al. 2020

Molecular Nutrition Food Res

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Scope To identify reliable biomarkers of food intake (BFIs) of pulses. Methods and results A randomized crossover postprandial intervention study is conducted on 11 volunteers who consumed lentils, chickpeas, and white beans. Urine and serum samples are collected at distinct postprandial time points up to 48 h, and analyzed by LC‐HR‐MS untargeted metabolomics. Hypaphorine, trigonelline, several small peptides, and polyphenol‐derived metabolites prove to be the most discriminating urinary metabolites. Two arginine‐related compounds, dopamine sulfate and epicatechin metabolites, with their microbial derivatives, are identified only after intake of lentils, whereas protocatechuic acid is identified only after consumption of chickpeas. Urinary hydroxyjasmonic and hydroxydihydrojasmonic acids, as well as serum pipecolic acid and methylcysteine, are found after white bean consumption. Most of the metabolites identified in the postprandial study are replicated as discriminants in 24 h urine samples, demonstrating that in this case the use of a single, noninvasive sample is suitable for revealing the consumption of pulses. Conclusions The results of the present untargeted metabolomics work reveals a broad list of metabolites that are candidates for use as biomarkers of pulse intake. Further studies are needed to validate these BFIs and to find the best combinations of them to boost their specificity.

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Serum untargeted metabolomic profile of the Dietary Approaches to Stop Hypertension (DASH) dietary pattern

Cited by 106 publications

References 51 publications

Plasma Metabolites Associate with All-Cause Mortality in Individuals with Type 2 Diabetes

Plasma Metabolites Associate with All-Cause Mortality in Individuals with Type 2 Diabetes

Ergothioneine is associated with reduced mortality and decreased risk of cardiovascular disease

Discovery of Intake Biomarkers of Lentils, Chickpeas, and White Beans by Untargeted LC–MS Metabolomics in Serum and Urine

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