Serum Unsaturated Free Fatty Acids: A Potential Biomarker Panel for Early-Stage Detection of Colorectal Cancer

Zhang, Yaping; He, Chengyan; Qiu, Ling; Wang, Yanmin; Qin, Xuzhen; Liu, Yujie; Li, Zhili

doi:10.7150/jca.13870

Cited by 36 publications

(22 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Table 3 summarizes results for metabolites that were assessed three times or more often in combination as potential markers in blood samples. Some studies focused primarily on amino acids [ 27 , 33 , 45 ] or on fatty acids and other lipid derivatives [ 25 , 26 , 29 , 30 , 36 , 41 , 43 , 46 ]. Some metabolites, e.g., arginine, histidine, or tyrosine, were consistently found to be downregulated in blood samples from CRC patients compared to those from healthy controls, but results from other metabolites are not as clear and further research is needed.…”

Section: Resultsmentioning

confidence: 99%

Metabolomics Biomarkers for Detection of Colorectal Neoplasms: A Systematic Review

Erben

Bhardwaj

Schrotz‐King

et al. 2018

Cancers

View full text Add to dashboard Cite

Background: Several approaches have been suggested to be useful in the early detection of colorectal neoplasms. Since metabolites are closely related to the phenotype and are available from different human bio-fluids, metabolomics are candidates for non-invasive early detection of colorectal neoplasms. Objectives: We aimed to summarize current knowledge on performance characteristics of metabolomics biomarkers that are potentially applicable in a screening setting for the early detection of colorectal neoplasms. Design: We conducted a systematic literature search in PubMed and Web of Science and searched for biomarkers for the early detection of colorectal neoplasms in easy-to-collect human bio-fluids. Information on study design and performance characteristics for diagnostic accuracy was extracted. Results: Finally, we included 41 studies in our analysis investigating biomarkers in different bio-fluids (blood, urine, and feces). Although single metabolites mostly had limited ability to distinguish people with and without colorectal neoplasms, promising results were reported for metabolite panels, especially amino acid panels in blood samples, as well as nucleosides in urine samples in several studies. However, validation of the results is limited. Conclusions: Panels of metabolites consisting of amino acids in blood and nucleosides in urinary samples might be useful biomarkers for early detection of advanced colorectal neoplasms. However, to make metabolomic biomarkers clinically applicable, future research in larger studies and external validation of the results is required.

show abstract

Section: Resultsmentioning

confidence: 99%

Metabolomics Biomarkers for Detection of Colorectal Neoplasms: A Systematic Review

Erben

Bhardwaj

Schrotz‐King

et al. 2018

Cancers

View full text Add to dashboard Cite

show abstract

“…Rifkin et al 17 found that increased risk of colorectal adenoma is associated with higher levels of ARA and lower levels of eicosapentaenoic acid (EPA, 20:5 n-3) in erythrocyte membrane phospholipids. In contrast the results of Zhang.et al 18 suggest that decreased ARA and docosahexaenoic acid (DHA, 22:6 n-3) may be diagnostic indicators of early-stage CRC. Also there are studies suggesting that some oxidized metabolites of PUFAs might be used as potential biomarkers of cancer 19,20 .…”

mentioning

confidence: 87%

Preferential uptake of polyunsaturated fatty acids by colorectal cancer cells

Mika

Kobiela

Pakiet

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Although a growing body of evidence suggests that colorectal cancer (cRc) is associated with alterations of fatty acid (FA) profiles in serum and tumor tissues, available data about polyunsaturated fatty acid (pUfA) content in cRc patients are inconclusive. our study showed that cRc tissues contained more pUfAs than normal large intestinal mucosa. However, serum levels of pUfAs in cRc patients were lower than in healthy controls. to explain the mechanism of pUfA alterations in cRc, we measured fA uptake by the colon cancer cells and normal colon cells. the levels of pUfAs in colon cancer cell culture medium decreased significantly with incubation time, while no changes were observed in the medium in which normal colon cells were incubated. Our findings suggest that the alterations in tumor and serum PUFA profiles result from preferential uptake of these FAs by cancer cells; indeed, PUFAs are essential for formation of cell membrane phospholipids during rapid proliferation of cancer cells. this observation puts into question potential benefits of PUFA supplementation in CRC patients.

show abstract

“…The impairment of insulin-mediated glucose uptake is correlated to the circulating FFA levels, and such resistance to insulin might be due to FFA-mediated inactivation of phosphoinositide 3-kinase (PI3K) [7]. Interestingly, cancer-related up-regulation of FFAs was also reported in several types of cancer in many previous studies [8–11]. …”

Section: Introductionmentioning

confidence: 99%

Role of free fatty acids in endothelial dysfunction

et al. 2017

View full text Add to dashboard Cite

Plasma free fatty acids levels are increased in subjects with obesity and type 2 diabetes, playing detrimental roles in the pathogenesis of atherosclerosis and cardiovascular diseases. Increasing evidence showing that dysfunction of the vascular endothelium, the inner lining of the blood vessels, is the key player in the pathogenesis of atherosclerosis. In this review, we aimed to summarize the roles and the underlying mechanisms using the evidence collected from clinical and experimental studies about free fatty acid-mediated endothelial dysfunction. Because of the multifaceted roles of plasma free fatty acids in mediating endothelial dysfunction, elevated free fatty acid level is now considered as an important link in the onset of endothelial dysfunction due to metabolic syndromes such as diabetes and obesity. Free fatty acid-mediated endothelial dysfunction involves several mechanisms including impaired insulin signaling and nitric oxide production, oxidative stress, inflammation and the activation of the renin-angiotensin system and apoptosis in the endothelial cells. Therefore, targeting the signaling pathways involved in free fatty acid-induced endothelial dysfunction could serve as a preventive approach to protect against the occurrence of endothelial dysfunction and the subsequent complications such as atherosclerosis.

show abstract

Serum Unsaturated Free Fatty Acids: A Potential Biomarker Panel for Early-Stage Detection of Colorectal Cancer

Cited by 36 publications

References 33 publications

Metabolomics Biomarkers for Detection of Colorectal Neoplasms: A Systematic Review

Metabolomics Biomarkers for Detection of Colorectal Neoplasms: A Systematic Review

Preferential uptake of polyunsaturated fatty acids by colorectal cancer cells

Role of free fatty acids in endothelial dysfunction

Contact Info

Product

Resources

About