1993
DOI: 10.1172/jci116387
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Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women.

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Cited by 456 publications
(270 citation statements)
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“…ucOC is a sensitive functional marker for vitamin K status [8]. Elevated concentrations of ucOC are associated with vitamin K deficiency and an increased risk of hip fractures [5,13,14,35,36]. Supplementation with vitamin K 2 promotes a decrease in ucOC, suggesting that vitamin K 2 contributes to OC carboxylation [9,37].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…ucOC is a sensitive functional marker for vitamin K status [8]. Elevated concentrations of ucOC are associated with vitamin K deficiency and an increased risk of hip fractures [5,13,14,35,36]. Supplementation with vitamin K 2 promotes a decrease in ucOC, suggesting that vitamin K 2 contributes to OC carboxylation [9,37].…”
Section: Discussionmentioning
confidence: 99%
“…Increased vitamin K intake causes a rapid decline in undercarboxylated OC (ucOC) [8,12], suggesting possible subclinical vitamin K deficiency in "healthy" bone tissue [4]. A high serum concentration of ucOC is correlated with an increased risk of hip fractures [13,14].…”
Section: Introductionmentioning
confidence: 99%
“…Elevated %ucOC has been associated with lower bone mineral density in elderly men and women (Booth et al, 2004). Low vitamin D status has also been associated with an elevated %ucOC (Szulc et al, 1993), although this association remains unconfirmed.…”
Section: Introductionmentioning
confidence: 99%
“…Subclinical vitamin K deficiency, indicated by undercarboxylation of plasma osteocalcin, has been implicated in the pathogenesis of osteoporotic fracture in most investigations (Szulc et al, 1993;Binkley & Suttie 1995;Vergnaud et al, 1997;Shiraki et al, 2000). Osteocalcin is the most abundant noncollagenous protein of bone.…”
Section: Introductionmentioning
confidence: 99%