Serum Ultrafiltrable Copper, Total Copper and Caeruloplasmin Concentrations in Gynaecological Carcinomas

Abstract

Serum copper and caeruloplasmin concentrations are elevated in various carcinomas, but it is not known whether the rise in serum copper is due to elevation of caeruloplasmin alone or whether it is also due to the elevation of ‘free’ copper. We therefore determined ultrafiltrable copper to answer this question. Serum ultrafiltrate was prepared using the Amicon micropartition system and ultrafiltrable (free) copper was determined by flameless atomic absorption spectrophotometry. Serum total copper was determined by flame atomic absorption spectrometry and caeruloplasmin by rate nephelometry. There was no significant difference in the ultrafiltrable copper concentration between patients with gynaecological tumours and control subjects. However, total copper and caeruloplasmin concentrations were significantly elevated in cancer patients compared with control subjects. In contrast to total copper and caeruloplasmin concentrations, ultrafiltrable copper concentrations showed no significant increase with increase in the stage of the cancer.

Detection and investigation of the molecular nature of low‐molecular‐mass copper ions in isolated rheumatoid knee‐joint synovial fluid

“…The mean copper ion concentration for SF was 1.25 + 0.95 × 10 -7 mol.dm -3 (mean + standard deviation) and for RA sera was 2.59 + 1.28 × 10 -7 mol'dm -3. The mean cop- t,er ion concentration for normal control sera was :.45 + 1.62 x 10 -7 mol.dm -3, a value which is comparable to previously reported levels [18] and significantly higher than that ,,f RA serum (P < 0.05) and SF (P < 0.01) (one-way analysis-,,f-variance (ANOVA) performed on untransformed data; fur1her comparisons of sample group means were made using ! 'ukey's test).…”

Determination of Serum Copper and Zinc Level of Bangladeshi Breast Cancer Patient

“…These free radicals induce mutations by damaging the nucleic acid, DNA. Thus, an increase in serum levels of copper may have a role of compounding factor in case of breast cancer [15]. Like breast cancer, gynaecological cancer has also been found to be directly related to high concentration of copper in blood serum [16].The results of the present study demonstrated increased concentration of Cu for breast cancer patients which support the argument with many of the previous study reported in the literature [12,13,17].…”

Serum glycoconjugates and ceruloplasmin in cancer of uterine cervix

“…A rise in serum ceruloplasmin was observed in cervical cancer (16,17,18). Arumanayagam et al have reported higher levels of ceruloplasmin in later stages of cancer compared to early stages (17).…”