Serum type IV collagen level is predictive for esophageal varices in patients with severe alcoholic disease

Mamori, Satoshi; Searashi, Yasuyuki; Matsushima, Masato; Hashimoto, Kazuhito; Uetake, Shinichiro; Miyata, Hiroshi; Ito, Shuji; Nakajima, Hiroyuki; Tajiri, Hisao

doi:10.3748/wjg.14.2044

Cited by 8 publications

(2 citation statements)

References 24 publications

(26 reference statements)

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“…In the first of only 2 studies in this area, the aminoterminal propeptide of type III procollagen was shown to have a weak correlation to the degree of oesophageal varices [ 26 ]. The second study by Mamori et al [ 27 ] included 44 patients with alcoholic liver disease and demonstrated a significant difference in serum type IV collagen levels between patients with and without varices (712.3 versus 404.3 ng/mL, P < 0.001), giving an AUROC of 0.78 for predicting the presence of oesophageal varices.…”

Section: Current Perspectives: Possible Approachesto Noninvasive Dmentioning

confidence: 99%

Towards Noninvasive Detection of Oesophageal Varices

Rye

Scott

Mortimore

et al. 2012

International Journal of Hepatology

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Current guidelines recommend that all cirrhotic patients should undergo screening endoscopy at diagnosis to identify patients with varices at high risk of bleeding who will benefit from primary prophylaxis. This approach places a heavy burden upon endoscopy units and the repeated testing over time may have a detrimental effect on patient compliance. Noninvasive identification of patients at highest risk for oesophageal varices would limit investigation to those most likely to benefit. Upper GI endoscopy is deemed to be the gold standard against which all other tests are compared, but is not without its limitations. Multiple studies have been performed assessing clinical signs and variables relating to liver function, variables relating to liver fibrosis, and also to portal hypertension and hypersplenism. Whilst some tests are clearly preferable to patients, none appear to be as accurate as upper GI endoscopy in the diagnosis of oesophageal varices. The search for noninvasive tests continues.

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Section: Current Perspectives: Possible Approachesto Noninvasive Dmentioning

confidence: 99%

Towards Noninvasive Detection of Oesophageal Varices

Rye

Scott

Mortimore

et al. 2012

International Journal of Hepatology

View full text Add to dashboard Cite

show abstract

“…Watanabe (43) calculated the splenic ratio (length x width x height of the spleen size on computed tomography), and showed that patients having a ratio over 963 cm 3 have esophageal varices, and that a high ratio may predict esophageal bleeding in patients with liver cirrhosis. It was concluded that ultrasonographic measurement of splenic craniocaudal diameter demonstrates lower inter-and intra-observer variability than Doppler sonographic assessment of hepatic flow (44,45).…”

Section: Discussionmentioning

confidence: 99%