Serum type III procollagen peptide, type IV collagen 7S domain, central triple-helix of type IV collagen and tissue inhibitor of metalloproteinases in patients with chronic viral liver disease: Relationship to liver histology

Abstract

To assess the clinical value of serum biochemical markers, the aminoterminal peptide of type III procollagen, type IV collagen 7S domain, the central triple-helix of type IV collagen and tissue inhibitor of metalloproteinases, as a marker of hepatic fibrosis, we measured these four serum markers in 132 patients with chronic viral liver disease and compared these serum markers with liver histological findings. Serum levels of these markers increased closely with the progress of liver disease, and the abnormal percentages of type III procollagen peptide, type IV collagen 7S domain, central triple-helix of type IV collagen and tissue inhibitor of metalloproteinases in patients with cirrhosis were 97%, 95%, 83% and 48%, respectively. These four serum markers strongly correlated with the histological degree of periportal with or without bridging hepatocellular necrosis and of liver fibrosis and correlated weakly with the degree of intralobular degeneration and focal necrosis and the degree of portal inflammation. The correlation coefficients of serum type IV collagen 7S domain with periportal with or without bridging hepatocellular necrosis and with liver fibrosis were the highest among these four serum markers, suggesting that serum type IV collagen 7S domain is the most valuable diagnostic marker to assess the degree of liver fibrosis in chronic viral liver disease. When we assessed the ability of each serum marker to detect cirrhosis with a receiver operating curve, the best test was type IV collagen 7S domain, and the second best was type III procollagen peptide.(ABSTRACT TRUNCATED AT 250 WORDS)

Progression of fibrosis in hepatitis C with and without schistosomiasis: Correlation with serum markers of fibrosis

“…15 A number of serological and urinary compounds such as procollagens, tissue inhibitors of metalloproteinases (TIMP), type IV S collagen, hyaluronic acid, and laminin and mediators of extracellular matrix production such as TGF-␤ have been evaluated as noninvasive markers of liver fibrosis. [16][17][18][19][20][21][22][23][24][25][26] Most of these studies have focused on using these markers in cross-sectional studies to diagnose the stage of liver fibrosis.…”

Fibrosis and disease progression in hepatitis C

“…Scores based on combinations of several biochemical tests have been assessed to predict liver fibrosis. 55 Many studies have assessed the correlation between liver fibrosis serum markers of fibrosis, such as type III procollagen peptide, 56 type IV collagen 7S domain, 56 hyaluronic acid, 57 laminin, 58 TGF-␤, 59 and metalloproteinases or metalloproteinase inhibitors. 59,60 Serum hyaluronic acid seems the best of these serum markers.…”

Role of α1 and α2 chains of type IV collagen in early fibrotic lesions of idiopathic interstitial pneumonias and migration of lung fibroblasts

“…In clinical situations, serum levels of type IV collagen in liver fibrosis and urine levels of type IV collagen in diabetic nephropathy reportedly correlate with the degree of liver and kidney fibrosis, respectively. 13,14 The serum concentrations of type IV collagen also increased in patients with IPF. 15 However, little is known of the expression and role of type IV collagen, especially in early fibrotic lesions of IIPs.…”