Serum tumour necrosis factor-??, interleukin-2 and interleukin-10 activation in stable angina and acute coronary syndromes

Mizia-Stec, Katarzyna; Gąsior, Zbigniew; Zahorska-Markiewicz, Barbara; Janowska, Joanna; Szulc, Andrzej; Jastrzębska-Maj, Ewa; Kobielusz-Gembala, Iwona

doi:10.1097/00019501-200309000-00003

Cited by 89 publications

(61 citation statements)

References 24 publications

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“…In contrast, IL-10 is an anti-inflammatory cytokine that can inhibit a broad array of inflammatory and immune responses. It has been reported that the levels of IL-10 are altered in ACS patients, but disappointedly, we failed to detect a difference in the IL-10 levels in the NSTACS patients (62)(63)(64)(65). This led to a reduced IL-10/TNF-␣ ratio in the patients with NSTACS compared with the CSA patients and the CPS controls.…”

Section: Treg Cells Rte-treg Cellscontrasting

confidence: 61%

Impaired Thymic Export and Increased Apoptosis Account for Regulatory T Cell Defects in Patients with Non-ST Segment Elevation Acute Coronary Syndrome

Zhang

Wang

Shu

et al. 2012

Journal of Biological Chemistry

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Background:The mechanisms of Treg cell defects in NSTACS patients remain unclear. Results: The frequency of RTE-Treg and TREC content were markedly lower, and apoptosis of Treg cells in NSTACS patients was markedly increased. Conclusion: Impaired thymic output and enhanced apoptosis were responsible for Treg cell defects in NSTACS patients. Significance: Our findings explain the mechanisms of Treg cell defects in NSTACS patients.

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Section: Treg Cells Rte-treg Cellscontrasting

confidence: 61%

Impaired Thymic Export and Increased Apoptosis Account for Regulatory T Cell Defects in Patients with Non-ST Segment Elevation Acute Coronary Syndrome

Zhang

Wang

Shu

et al. 2012

Journal of Biological Chemistry

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“…Furthermore, IL-10 transgenic mice showed reduced atherosclerosis, whereas IL-10-deficient mice exhibited increased early atherosclerotic lesion formation (193), illustrating the anti-atherogenic potential of IL-10. However, results from clinical studies are not consistent as some report higher IL-10 levels in patients with ACS (133,183), whereas other report lower levels in patients with CAD (115) and unstable angina (256).…”

Section: Adipokines With a Tight Link To Cardiovascular Diseasementioning

confidence: 95%

Inflammation and metabolic dysfunction: links to cardiovascular diseases

Taube

Schlich

Sell

et al. 2012

American Journal of Physiology-Heart and Circulatory Physiology

200

133

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Abdominal obesity is a major risk factor for cardiovascular disease, and recent studies highlight a key role of adipose tissue dysfunction, inflammation, and aberrant adipokine release in this process. An increased demand for lipid storage results in both hyperplasia and hypertrophy, finally leading to chronic inflammation, hypoxia, and a phenotypic change of the cellular components of adipose tissue, collectively leading to a substantially altered secretory output of adipose tissue. In this review we have assessed the adipo-vascular axis, and an overview of adipokines associated with cardiovascular disease is provided. This resulted in a first list of more than 30 adipokines. A deeper analysis only considered adipokines that have been reported to impact on inflammation and NF-κB activation in the vasculature. Out of these, the most prominent link to cardiovascular disease was found for leptin, TNF-α, adipocyte fatty acid-binding protein, interleukins, and several novel adipokines such as lipocalin-2 and pigment epithelium-derived factor. Future work will need to address the potential role of these molecules as biomarkers and/or drug targets.

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“…Interleukin-6 (IL-6) was the first cytokine reported to be elevated in patient with unstable angina, and the degree of elevation correlated with the patients subsequent clinical outcome. Interleukin-1ß (IL-1ß) and tumor-necrosis-factor-a (TNF-a) are well-characterized proinflammatory cytokines with demonstrated roles in the progression of atherosclerosis [3][4][5][6][7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Cardiac release and kinetics of cytokines after elective bare metal coronary stenting

El-Mokhtari

Zschernitz

Sebens

et al. 2010

J Thromb Thrombolysis

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The study was designed to assess the cardiac release kinetics of the cytokines interleukin-1ß (IL-1ß), interleukin-6 (IL-6) and tumor-necrosis-factor-α (TNF-α) in patients with significant stenosis of the ramus interventricularis anterior. Ten patients were treated by bare metal stent implantation, 11 patients who underwent a diagnostic coronary angiography without intervention served as a control group. Cytokines paired blood samples were withdrawn from the coronary sinus and a peripheral vein immediately before and 1, 2, 6 h after the intervention. Myocardial ischemia was monitored by means of cardiac lactate metabolism and 12-lead electrocardiogram. After coronary intervention IL-6 gradually increased from a common baseline level of 1.34 ± 1.56 pg/ml to a maximum of 10.58 ± 5.7 pg/ml in the peripheral vein and 15.81 ± 6.98 pg/ml in the coronary sinus within 6 h with persistent higher levels in the coronary sinus indicating coronary IL-6 release. After 12 h the peripheral venous concentration of IL-6 returned to baseline levels. Neither in the study group for IL-1ß and TNF-α nor in the control group for any cytokine level significant changes were found. Myocardial ischemia was excluded in all patients. Uncomplicated percutaneous coronary intervention (PCI) was followed by a significant cardiac IL-6 release due to endothelial injury and not to myocardial ischemia.

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Serum tumour necrosis factor-??, interleukin-2 and interleukin-10 activation in stable angina and acute coronary syndromes

Cited by 89 publications

References 24 publications

Impaired Thymic Export and Increased Apoptosis Account for Regulatory T Cell Defects in Patients with Non-ST Segment Elevation Acute Coronary Syndrome

Impaired Thymic Export and Increased Apoptosis Account for Regulatory T Cell Defects in Patients with Non-ST Segment Elevation Acute Coronary Syndrome

Inflammation and metabolic dysfunction: links to cardiovascular diseases

Cardiac release and kinetics of cytokines after elective bare metal coronary stenting

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