Serum tumor necrosis factor alpha (TNF-α) level in patients with Behçet’s disease: Relation to clinical manifestations and disease activity

Menyawi, Manal El; Fawzy, Mary; Alnahas, Zeinab; Edris, Amr E.; Hussein, Hanan; Shaker, Olfat G.; Elwan, Hussein

doi:10.1016/j.ejr.2014.01.004

Cited by 20 publications

(13 citation statements)

References 19 publications

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“…The demographic, clinical, and laboratory data of three groups, and their statistical comparisons were shown in Table I. Table II presents between active and inactive BD groups with respect to TNF-alpha level whereas serum levels of ESR and CRP were similar in both groups (42). In our study, on the other hand, the patients with active disease had a significantly higher levels of ESR and CRP compared to the inactive disease group.…”

Section: Resultsmentioning

confidence: 45%

A Novel Marker Demonstrating Endothelial Dysfunction in Behçet's Disease, YKL-40

Gündüz¹,

Türkçü²,

Batmaz³

et al. 2016

West Indian Med J

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Background: To evaluate the relationship between disease activity and levels of YKL-40 in patients with Behcet's disease (BD). Methods: Twenty five active and twenty six inactive BD patients and 24 age and gender matched healthy control subjects were included in the study. Serum YKL-40 levels were measured using Enzyme Linked Immuno Sorbent Assay (ng/mL). Disease activity was assessed using Behcet's Disease Current Activity Form (BDCAF). Results: Serum YKL-40 levels were significantly higher in patients with active BD and inactive BD compared to the control group (respectively p<0.001, p< 0.001). There were no significant differences between active and inactive BD groups in terms of levels of YKL-40 (p=0.9). According to Pearson's analysis, YKL-40 levels were significantly positively correlated with Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and skin lesions of BDCAF scores. Conclusion: Our study demonstrated that serumYKL-40 level was significantly higher in active and inactive BD compared to healthy controls. However, the groups with active and inactive disease had no significant difference with respect to YKL-40 level. In addition, there existed a significant correlation between serum YKL-40 level and ESR, CRP, and BDCAF's skin scores.

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Section: Resultsmentioning

confidence: 45%

A Novel Marker Demonstrating Endothelial Dysfunction in Behçet's Disease, YKL-40

Gündüz¹,

Türkçü²,

Batmaz³

et al. 2016

West Indian Med J

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“…Significantly higher TNF-α level has been reported in BD patients with active disease compared to those with inactive disease. 14 , 54 Contrary to these, the G allele and GG genotype of TNF-α (308) polymorphism have been associated with increased risk of BD in Koreans, 55 while no association of TNF-α (308) polymorphism with BD was reported in Turkish, 22 , 56 , 57 Korean, 58 Tunisian, 23 Lebanes, 59 Iranian, 60 and Moroccan population. 25 …”

Section: Discussionmentioning

confidence: 88%

Inflammation-related cytokine gene polymorphisms in Behçet’s disease

Alokaily

Arfin²,

Alrashidi

et al. 2015

JIR

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Behçet’s disease (BD) is a complex, multisystemic inflammatory disorder of unclear etiology. Single nucleotide polymorphisms in tumor necrosis factor (TNF) and interleukin (IL)-10 genes have been implicated in susceptibility to BD with inconsistent results in several ethnic populations. The aim of this case-control study was to evaluate the association of TNF-α (−308G/A), TNF-β (+252A/G), and IL-10 (−1082G/A, −819C/T, and −592 C/A) polymorphisms with susceptibility of BD in Saudi patients. Molecular genotyping of TNF-α, TNF-β, and IL-10 gene polymorphisms was performed to analyze the alleles and genotypes distribution in 272 Saudi subjects, including BD patients (61) and healthy controls (211). The frequencies of allele A and genotype GA of TNF-α (−308G/A) were significantly higher, whereas those of allele G and genotypes GG were significantly lower in BD patients than controls, indicating that A allele and GA genotype are susceptible, while G allele and GG genotype may be refractory to BD. The distribution of frequencies of alleles and genotype of TNF-β (+252A/G) promoter polymorphism was not significantly different between BD patients and healthy controls. Genotypes 1082GG, −819TT, and 592AA of IL-10 polymorphisms are significantly associated with susceptibility risk of BD, while genotypes 1082AA, 1082GA, 819CC, 819CT, 592CC, and 592CA are resistant to BD. This study indicates that TNF-α (−308G/A) and IL-10 (−1082G/A, −819C/T, and −592C/A) polymorphisms are associated with risk of BD susceptibility in Saudi patients. However, larger scale studies in Saudi population as well as in other ethnicities are needed to confirm this association.

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“…These findings suggest that TNFα and MMPs are related to aneurysm formation. Furthermore, the serum levels of TNFα are higher in BD patients than in healthy controls (22), and the serum levels of MMP-2 and MMP-9 were higher in vascular BD patients with aneurysm than in healthy controls or BD patients with mucocutaneous or ocular involvement (23). Regarding the murine model of abdominal aortic aneurysm induced by chemical inflammation in the arterial wall via the local injection of CaCl2, the TNFα expression was reported to be upregulated one week after aneurysm induction (24).…”

Section: Discussionmentioning

confidence: 99%

Aortic Arch Aneurysm in Behçet Disease Successfully Treated with Infliximab

et al. 2020

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Aortic arch aneurysm (AAA) is a rare involvement in Behçet disease (BD). It is often life-threatening, yet few reports related to the treatment of AAA have been published. We herein report a 27-year-old woman with AAA caused by vascular BD. She was initially treated with prednisolone 1 mg/kg/d. However, the inflammation had not subsided after three weeks, so infliximab (IFX) was added for relief. After IFX administration, the C-reactive protein level normalized, and computed tomography at three months after therapeutic intervention revealed that the aneurysm had disappeared. This case suggests that early induction of IFX might be effective for aortic aneurysm in BD.

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Serum tumor necrosis factor alpha (TNF-α) level in patients with Behçet’s disease: Relation to clinical manifestations and disease activity

Cited by 20 publications

References 19 publications

A Novel Marker Demonstrating Endothelial Dysfunction in Behçet's Disease, YKL-40

A Novel Marker Demonstrating Endothelial Dysfunction in Behçet's Disease, YKL-40

Inflammation-related cytokine gene polymorphisms in Behçet’s disease

Aortic Arch Aneurysm in Behçet Disease Successfully Treated with Infliximab

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Serum tumor necrosis factor alpha (TNF-α) level in patients with Behçet’s disease: Relation to clinical manifestations and disease activity

Cited by 20 publications

References 19 publications

A Novel Marker Demonstrating Endothelial Dysfunction in Behçet's Disease, YKL-40

A Novel Marker Demonstrating Endothelial Dysfunction in Behçet's Disease, YKL-40

Inflammation-related cytokine gene polymorphisms in Beh&ccedil;et&rsquo;s disease

Aortic Arch Aneurysm in Behçet Disease Successfully Treated with Infliximab

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Product

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Inflammation-related cytokine gene polymorphisms in Behçet’s disease