Serum TSH related to measures of body mass: longitudinal data from the HUNT Study, Norway

Svare, Anders; Nilsen, Turid; Bjøro, Trine; Åsvold, Bjørn Olav; Langhammer, Arnulf

doi:10.1111/j.1365-2265.2011.04009.x

Cited by 100 publications

(103 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, the Norwegian population has long been considered to be iodine sufficient (15), and it seems unlikely that changes in iodine intake may explain the changes that we observed. Smoking (16,17), alcohol consumption (18), and adiposity (19,20,21) are other factors that could influence the prevalence of hypothyroidism or prevalence of high TSH concentrations, but statistical adjustment for differences in smoking habits, alcohol consumption, and BMI between the surveys did not substantially influence the changes in prevalence in our study.…”

Section: Huntmentioning

confidence: 56%

Changes in the prevalence of hypothyroidism: the HUNT Study in Norway

Åsvold

Vatten

Bjøro

2013

European Journal of Endocrinology

Self Cite

View full text Add to dashboard Cite

Objective: Untreated hypothyroidism is common in iodine-replete areas. Frequent thyroid function testing and use of levothyroxine treatment for subclinical hypothyroidism suggest that the prevalence may have decreased. Therefore, in this study, we examined changes in the prevalence of hypothyroidism in a Norwegian county from 1995-1997 to 2006-2008 The corresponding decrease among men was 43% from 0.21 to 0.12% (PR 0.57; 95% CI 0.28-1.16). The prevalence of untreated subclinical hypothyroidism decreased by 64% from 3.0 to 1.1% in women (PR 0.36; 95% CI 0.31-0.42) and decreased by 54% from 2.1 to 1.0% in men (PR 0.46; 95% CI 0.38-0.56). Conversely, the prevalence of treated hypothyroidism among women increased by 60% from 5.0 to 8.0% (PR 1.60, 95% CI 1.50-1.71), and the corresponding prevalence in men doubled from 1.0 to 2.0% (PR 1.96; 95% CI 1.59-2.41). The prevalence of any form of hypothyroidism remained essentially similar at 9% in women and 3% in men. Conclusions: The prevalence of untreated hypothyroidism in this Norwegian county decreased strongly from 1995-1997 to 2006-2008. The findings suggest that the prevalence of untreated hypothyroidism in populations with easy access to thyroid function testing and levothyroxine treatment may now be low.

show abstract

Section: Huntmentioning

confidence: 56%

Changes in the prevalence of hypothyroidism: the HUNT Study in Norway

Åsvold

Vatten

Bjøro

2013

European Journal of Endocrinology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Most population-based studies in healthy (non-LT4 treated) subjects have shown a direct correlation between serum TSH levels within the reference range and body weight, BMI, or fat mass (reviewed by Garin et al) (40), suggesting a role for thyroid-inducible metabolism on body weight and composition. Longitudinal studies have been more divergent, with some but not all studies reporting a correlation between baseline TSH, fT4, or fT3 and weight gain over time (40)(41)(42)(43)(44)(45). However, the correlations have been in different directions, and the point has been raised that weight change may affect thyroid hormone levels, rather than thyroid hormones affecting weight change (46).…”

Section: Lt4 Therapy Energy Expenditure and Body Compositionmentioning

confidence: 99%

Effects of Levothyroxine Replacement or Suppressive Therapy on Energy Expenditure and Body Composition

Samuels

Kolobova

Smeraglio

et al. 2016

Thyroid

View full text Add to dashboard Cite

Background: Thyrotropin (TSH)-suppressive doses of levothyroxine (LT4) have adverse effects on bone and cardiac function, but it is unclear whether metabolic function is also affected. The objective of this study was to determine whether women receiving TSH-suppressive LT4 doses have alterations in energy expenditure or body composition. Methods: This study was a cross-sectional comparison between three groups of women: 26 women receiving chronic TSH-suppressive LT4 doses, 80 women receiving chronic replacement LT4 doses, and 16 untreated euthyroid control women. Subjects underwent measurements of resting energy expenditure (REE), substrate oxidation, and thermic effect of food by indirect calorimetry; physical activity energy expenditure by accelerometer; caloric intake by 24-hour diet recall; and body composition by dual X-ray absorptiometry. Results: REE per kilogram lean body mass in the LT4 euthyroid women was 6% lower than that of the LT4-suppressed group, and 4% lower than that of the healthy control group ( p = 0.04). Free triiodothyronine (fT3) levels were directly correlated with REE, and were 10% lower in the LT4 euthyroid women compared with the other two groups ( p = 0.007). The groups of subjects did not differ in other measures of energy expenditure, caloric intake, or body composition. Conclusions: LT4 suppression therapy does not adversely affect energy expenditure or body composition in women. However, LT4 replacement therapy is associated with a lower REE, despite TSH levels within the reference range. This may be due to lower fT3 levels, suggesting relative tissue hypothyroidism may contribute to impaired energy expenditure in LT4 therapy.

show abstract

“…In previous studies, we and others have found an association between serum TSH within the reference range and serum lipid levels (5,6), body weight (7,8), and blood pressure (9). Altered serum TSH level appears to be an important risk factor for disease in general.…”

Section: Introductionmentioning

confidence: 99%

The Phosphodiesterase 8B Gene rs4704397 is Associated with Thyroid Function, Risk of Myocardial Infarction, and Body Height: The Tromsø Study

Jorde

Schirmer

Wilsgaard

et al. 2014

Thyroid

View full text Add to dashboard Cite

Objective: High serum thyrotropin (TSH) levels predict cardiovascular disease (CVD). Recently several single nucleotide polymorphisms (SNPs) associated with TSH levels have been identified, one of them being the rs4704397 SNP in the phosphodiesterase 8B (PDE8B) gene. If the relation between thyroid function and CVD is causal, one could also expect rs4704397 genotypes to predict CVD and possibly health in general. Methods: DNA was prepared and genotyping performed for rs4704397 in subjects who participated in the fourth survey of the Tromsø Study in 1994-1995 and who were registered with the endpoints myocardial infarction (MI), type 2 diabetes (T2DM), cancer, or death, as well as a randomly selected control group. Similarly, genotyping was performed in subjects who had participated in clinical trials where serum TSH, free T4 (fT4), and free T3 (fT3) were measured. Results: From the Tromsø Study, 8938 subjects without thyroid disease or thyroid medication were successfully genotyped for rs4704397. Among these, 2098 were registered with MI, 1025 with T2DM, 2748 with cancer, and 3592 had died. The minor homozygote genotype (A:A) had a median serum TSH level that was 0.29 mIU/L higher than in the major homozygote genotype (G:G). The A:A genotype had a significantly increased risk of MI as compared to the G:G genotype (1.14 [1.00-1.29], hazard ratio [confidence interval], Cox regression with adjustment for age, sex, and body mass index). No significant associations were seen with the other endpoints or CVD risk factors. Furthermore, subjects with the G:G genotype were significantly taller than subjects with the A:A genotype (mean difference 1.5 cm). In 584 subjects with serum TSH, fT4, and fT3 measurements, the subjects with the A:A genotype had significantly higher serum TSH and nonsignificantly lower serum fT3 (mean difference 0.15 pmol/L) levels than subjects with the G:G genotype. Conclusion: rs4704397 is associated with thyroid function, risk of MI, and body height. However, confirmation in other cohorts is needed before firm conclusions can be drawn.

show abstract

Serum TSH related to measures of body mass: longitudinal data from the HUNT Study, Norway

Abstract: Weight gain is accompanied by increasing TSH, and weight loss in women is related to decreasing TSH.

Cited by 100 publications

References 32 publications

Changes in the prevalence of hypothyroidism: the HUNT Study in Norway

Changes in the prevalence of hypothyroidism: the HUNT Study in Norway

Effects of Levothyroxine Replacement or Suppressive Therapy on Energy Expenditure and Body Composition

The Phosphodiesterase 8B Gene rs4704397 is Associated with Thyroid Function, Risk of Myocardial Infarction, and Body Height: The Tromsø Study

Contact Info

Product

Resources

About