“…Two reports of the Multiple Risk Factor Intervention Trial (MRFIT) study disagreed, however: the 25-year follow-up analysis reported a significant association, whereas a 6.1-year follow-up did not (the article reporting the 25-year follow-up was used for the MRFIT study) 11,22. After excluding duplicate reports of the same cohort, a report in which the outcome was all-cause deaths,24 and a report in which the outcome was heart failure,26 32 reports with coronary events or coronary death as outcome remained and were included in the analysis 11,14,18,20–23,25,27,30–32,34,36–50,52,54–56. As some articles described more than one cohort,11 more than one subpopulation of a cohort (eg, men and women separately), and we included only one outcome measure per cohort (coronary events only, if coronary deaths were also reported), results for a total of 38 different populations were included in the analysis.…”