Serum Triglycerides as an Independent Risk Factor for Death From Coronary Heart Disease in Mtddle-Aged Norwegian Men

Abstract

The relation between nonfasting serum triglycerides and death from coronary heart disease was studied in 37,546 men aged 35-49 years who were examined during 1972-1977 in four counties in Norway. During an average follow-up period of nine years, 369 deaths from coronary heart disease occurred. In univariate analysis, log(triglycerides) were a weak, but statistically significant predictor of coronary death in the age groups 40-44 and 45-49 years. Within-area analysis showed that a high triglyceride area represented no extreme. When other coronary risk factors were adjusted for, log(triglycerides) remained a significant independent predictor at ages 45-49 years and at higher levels of serum cholesterol. The predictive strength of serum cholesterol was largely the same whether log(triglycerides) were taken into account or not, whereas the predictive strength of log(triglycerides) depended on whether serum cholesterol was accounted for. The strength of coronary death prediction of the logarithm of serum triglycerides was hardly greater than might be explained by the fact that triglycerides are an indicator of the usual cholesterol level of the subject.

Intermedin protects against myocardial ischemia-reperfusion injury in hyperlipidemia rats

“…Several large observational studies have assessed the association between blood lipid concentrations and cardiovascular risk. It was reported that both higher TG and TC levels were significant independent predictors of coronary death only in participants in the upper age range (Tverdal et al, 1989). After simultaneous adjustment for a variety of coronary risk factors, TG concentrations manifested significant correlation with MI, ischemic heart disease and survival after 26 years of follow-up in a large-scale prospective cohort study (Nordestgaard et al, 2007).…”

Non-fasting serum triglyceride concentration and mortality from coronary heart disease and any cause in middle aged Norwegian women.

“…The previous study on men also included the Oslo study and the Troms0 study (1974), in which only men were studied. 6 A detailed description of the study procedures has been given by Bjartveit et al7 All people participating answered a questionnaire at home about history of cardiovascular disease, diabetes, treatment for hypertension, symptoms of angina pectoris, physical activity during leisure, smoking habits, and stress factors in social life. In this study the healthy group consists of those who gave negative answers to questions about myocardial infarction, angina pectoris, other heart disease, atherosclerosis of legs, cerebral stroke, diabetes, treatment for hypertension, use of nitroglycerine, and symptoms suggesting angina pectoris or atherosclerosis obliterans, or both.…”

“…From these studies we have previously reported non-fasting triglyceride concentration to be a weak predictor of death from coronary heart disease in men; the strength of association depending heavily on whether total cholesterol concentration was accounted for. 6 The period of follow up is now sufficient (12 to 16 years) to give fairly precise estimates of the relation between triglyceride concentration and mortality from coronary disease in women.…”

The Increased Risk of Colon Cancer Due to Cigarette Smoking May Be Greater in Women than Men

“…We collapsed current and former smokers to ever-smokers. We further categorized ever-smokers according to the following factors: age at smoking initiation (16,(17)(18)(19)(20)(21)(22)(23)(24), 25 years), numbers of cigarettes smoked per day (1-9, [10][11][12][13][14][15][16][17][18][19]20), smoking duration in years (1-19, 20-29, 30-39, 40), and number of pack-years (i.e., number of cigarettes smoked per day, divided by 20, multiplied by the duration of smoking in years; 0-9, 10-19, 20). All subjects not being current or former smokers were classified as never smokers.…”