Serum trace elements in insulin-dependent and non-insulin-dependent diabetes: a comparative study

Ahmed, Ahmed M.; Khabour, Omar F.; Awadalla, Akram H.; Waggiallah, Hisham Ali

doi:10.2147/dmso.s186602

Cited by 15 publications

(10 citation statements)

References 53 publications

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“…Previous studies have shown inconsistent fallouts with regard to Cu status in diabetes patients. E.g., reduction or no alteration in Cu levels has been stated in (Leonhardt et al, 1996;Rohn et al, 1993) and no statistical difference existed in Copper level in diabetic and healthful patients (Kazi et al, 2008;Ekmekcioglu et al, 2001) whereas increased plasma Cu levels as stated in (Ahmed, 2018;Qiu et al, 2017Qiu et al, ) (J et al, 2017. No signi icant correlation between copper and FBS, AGE, BMI, DUR(duration).…”

Section: Coppermentioning

confidence: 92%

“…Trace elements like Zn, Se, Cr, Mg, and other have essential functions in cellular homeostasis and body metabolism (Ferreira and Gahl, 2017). This consists of creation, emission and insulin activity passageway (Ahmed, 2018) (Sun et al, 2018;Triggiani, 2006) . Increase insulin sensitivity and acts as an antioxidant that prevents tissue for each oxidation, helping as a co factor for enzyme systems that participating in glucose metabolic rate (Akinloye et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of some trace elements status in females type 1 diabetics patients and its relationship with oxidative stress

Ali

Mahdi

Kareem

et al. 2019

ijrps

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Disorders of trace elements in diabetic patients with type 1 are possibly led to glucose metabolism disturbance and increased oxidation, which may promote the development of diabetes and insulin resisting. We aim to clarify the role of the serum level of zinc (Zn), copper (Cu), cobalt (Co), iron (Fe), Zn/Cu ratio and their relations with the degree of oxidative stress in females T1D. The study included 30 healthy women and 54 women with insulin-dependent diabetes. Serum levels of trace element have determined by atomic absorption spectrophotometer. Results showed a decrease levels of Cu, Fe, Zn and MDA in diabetes patients compared to controls (p <0.000), (p < 0.000) (p< 0.001) (p <0.001) correspondingly. Significance in correlations amid Zn and age (r= -0.449, p <0.032), significance in correlations among Co in addition to age (r= -0.434, p <0.038) with significances in correlation amid Fe and MDA (r= 0.024, p <0.366).

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Section: Coppermentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Evaluation of some trace elements status in females type 1 diabetics patients and its relationship with oxidative stress

Ali

Mahdi

Kareem

et al. 2019

ijrps

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“…ey explained also the deficiency of some trace elements in diabetic patients that play a great role in the development of diabetes mellitus [64][65][66][67]. Ahmed et al reported that several trace elements are significantly reduced in people with diabetes mellitus [67,68]. Also, other work reported that the trace elements Ca and K regulate voltage-dependent channels in pancreatic β-cells, which are essential for insulin exocytosis [69][70][71].…”

Section: 42mentioning

confidence: 99%

Characterization of an Endemic Plant Origanum grosii from Morocco: Trace Element Concentration and Antihyperglycemic Activities

Hassouni

hajji²,

Bnouham

et al. 2021

Journal of Chemistry

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Origanum genus is one of the most widely used herbs in folk medicine for its biological properties. The present investigation aims to characterize, for the first time, endemic Origanum grosii collected from the Taounate region, Morocco. This characterization was realized by determining the concentration of metals in different parts of the plant (flowers, leaves, and stems) by ICP-MS, and the results were studied statistically by Principal Component Analysis (PCA). Phytochemical screening with the dosage of polyphenols and flavonoids has been conducted. To know more about this species, antihyperglycemic tests have been performed to highlight the presence or absence of the antidiabetic effect for this plant. An Oral Glucose Tolerance Test (OGTT) has been performed on normal mice which were divided into two groups of six mice each. Group 1 (control group) was treated with distilled water, and group 2 was treated with an aqueous extract of O. grosii by gavage at 150 mg/kg. Digestive enzyme α-amylase inhibition assay has also been evaluated to study the inhibition effect of the studied extract using acarbose as a control. The results showed that the leaves exhibited a high concentration of trace elements (Ca, Mg, and K) and total absence of heavy metals, which were found in small quantities (Cr, Ni, and B) on the stems, and this makes the plant safe to use. On the other hand, tannins, flavonoids, triterpenes, and steroids were the major families strongly present in this species. The antidiabetic results showed that O. grosii have significantly reduced postprandial hyperglycemia after glucose loading in normal rats. It showed also that this species has a significant antihyperglycemic activity reflected by the inhibition of α-amylase. The one responsible for this property could be the synergy between the trace elements and the nature of the chemical families of O. grosii species, which can make this plant useful in the management of postprandial hyperglycemia.

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“…Around 20% of Indian babies are born with LBW despite the mandatory iron and folate supplementation to all pregnant Indian mothers. 28 Minerals like Mg and Zn are deficient among Indian women 29 and Mg, Zn, Mn, and Cr modulate insulin, 30 the sole anabolic hormone that regulates macronutrient metabolism and is vital for fetal growth. Therefore, we assessed next, the effect of maternal dietary restriction of these minerals singly as per the study protocol presented in ►Fig.…”

Section: Our Studies In Rat and Mice Modelsmentioning

confidence: 99%

Do Maternal Micronutrient Deficiencies Program the Body Composition and Behavior of the Offspring? Probable Underlying Mechanisms

Kalle

Ghosh

Thomas

et al. 2019

Annals of the National Academy of Medical Sciences (India)

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Obesity and noncommunicable diseases (NCDs) like diabetes are epidemic in India. Developmental origins of health and disease hypothesis, based on epidemiological evidence, associates maternal undernutrition and low birth weight (LBW) of the offspring with increased obesity and diabetes in their later life. Considering widespread maternal micronutrient (MN) deficiencies, LBW, and NCDs in India, we tested the hypothesis, “maternal MN deficiency per se programs the offspring for obesity and increases risk for NCDs in their later life” in rodent models. We showed in Wistar rat offspring that maternal MN (single or combined) deficiency per se: (1) increased body fat (visceral fat) and altered lipid metabolism, (2) decreased lean body and fat free mass, and (3) altered muscle function and altered glucose tolerance/metabolism and insulin sensitivity. Rehabilitation prevented vitamin but not mineral restriction-induced changes in offspring, which showed partial mitigation. Increased oxidative/steroid stress, decreased antioxidant status, and inflammatory state were the associated common mechanisms in the offspring. Our attempts to assess the role of epigenetics showed that folate and/or vitamin B12 deficiencies altered mother’s body composition besides that of the offspring. Additionally, in C57BL/6 mice, B12 deficiency-induced anxiety was observed in mothers and offspring. That expressions of histone modifying enzymes in mice brain and promoter methylation of adiponectin, leptin, and 11βHSD1 genes in rat offspring were altered in MN (B12 and Mg) deficiency suggested that altered epigenetics most likely plays a role in maternal MN deficiency-induced changes in body fat/lipid metabolism and anxiety-like behavior in mothers and offspring.

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Serum trace elements in insulin-dependent and non-insulin-dependent diabetes: a comparative study

Cited by 15 publications

References 53 publications

Evaluation of some trace elements status in females type 1 diabetics patients and its relationship with oxidative stress

Evaluation of some trace elements status in females type 1 diabetics patients and its relationship with oxidative stress

Characterization of an Endemic Plant Origanum grosii from Morocco: Trace Element Concentration and Antihyperglycemic Activities

Do Maternal Micronutrient Deficiencies Program the Body Composition and Behavior of the Offspring? Probable Underlying Mechanisms

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