Serum trace element levels in HIV-infected subjects

Beck, Karl W.; Schramel, P.; Hedl, A.; Jaeger, Hans; Kaboth, W

doi:10.1007/bf02990269

Cited by 39 publications

(16 citation statements)

References 38 publications

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“…Our study demonstrates that serum selenium concentration declines with disease progression in HIV-infected individuals; these results agree with the observations of previous investigators (Dworkin et al, 1988;Olmsted et al, 1989;Beck et al, 1990;Cirelli et al, 1991;Dworkin, 1994).…”

Section: Discussionsupporting

confidence: 93%

Serum selenium, plasma glutathione (GSH) and erythrocyte glutathione peroxidase (GSH-Px)-levels in asymptomatic versus symptomatic human immunodeficiency virus-1 (HIV-1)-infection

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Rockstroh

Rao³

et al. 1997

Eur J Clin Nutr

137

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Objectives: Antioxidant defense status was investigated in HIV-infected patients by measuring serum selenium, erythrocyte glutathione peroxidase (GSH-Px) activity, plasma thiol (-SH) and glutathione (GSH) concentrations along with the assessment of the clinical stage and surrogate markers of HIV-disease. Design, setting and subjects: Serum selenium levels were determined cross-sectionally in 104 sequentially selected HIV-infected patients (83 outpatients and 21 patients with ongoing AIDS de®ning events). The patients were classi®ed into three stages of the disease, I, II and III according to the 1993 Centers For Disease Control (CDC) classi®cation system for HIV-infection. GSH-Px activities, plasma SH and plasma GSH concentrations were determined in a subset of 24 patients at stage I and 12 patients at stage III with an active AIDS-de®ning disease. Results: Mean serum selenium levels were lower in CDC stage II (68.7 AE 20.9 mg/l; P`0.01; n 34) and stage III (51.4 AE 14.7 mg/l; P`0.01; n 37) HIV-infected patients than in healthy subjects (89.2 AE 20.9 mg/l; n 72) and stage I patients (82.3 AE 20.5; mg/l; n 33). Serum selenium levels were positively correlated with CD4-count (r 0.42; P`0.001; n 104) and inversely with levels of soluble tumor necrosis factor receptors type II (r 7 0.58; P`0.01; n 35), neopterin (r 70.5; P`0.001; n 80) and b2-microglobulin (r 70.4; P`0.001; n 94). Hepatitis C virus (HCV) and HIV-coinfected patients at CDC stages I and II showed markedly lower selenium concentrations compared to HIV-infected patients without concomitant HCVinfection. Serum selenium and GSH-Px activity in hospitalized AIDS patients was signi®cantly lower as compared to asymptomatic patients and healthy subjects, whereas plasma SH and GSH concentrations were lower in both, asymptomatic -and AIDS-patients, than in the controls. Conclusion:The results show that stages I±III of HIV-disease are characterized by signi®cant impairments of antioxidative defenses provided by selenium, GSH-Px, SH-groups and GSH. Sponsorship:

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Section: Discussionsupporting

confidence: 93%

Serum selenium, plasma glutathione (GSH) and erythrocyte glutathione peroxidase (GSH-Px)-levels in asymptomatic versus symptomatic human immunodeficiency virus-1 (HIV-1)-infection

Look

Rockstroh

Rao³

et al. 1997

Eur J Clin Nutr

137

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“…In contrast with our study, several cross-sectional studies have reported a significant association between low selenium concentrations and HIV infection (24)(25)(26)(27)(28). In these reports, various mechanisms have been postulated for the selenium deficiency observed, including inadequate intake, malabsorption, or overutilization and depletion of selenium that prevents adequate restoration (3,4).…”

Section: Discussioncontrasting

confidence: 84%

Plasma Selenium Concentrations Are Sufficient and Associated with Protease Inhibitor Use in Treated HIV-Infected Adults

Hileman

Dirajlal-Fargo

Lam

et al. 2015

The Journal of Nutrition

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Plasma selenium concentrations were within the normal range for the background population and were not associated with subclinical vascular disease in HIV-infected adults on contemporary ART. The association between current PI use and higher selenium may have implications for ART allocation, especially in resource-limited countries. Also, it appears that statin therapy may increase selenium concentrations; however, larger studies are necessary to confirm this finding. This trial was registered at clinicaltrials.gov as NCT01218802.

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“…Products of lipid peroxidation, as measured by the concentration of thiobarbituric acid-reactive substances, were found to be significantly higher in HIVseropositive subjects, although we could not confirm this finding [5,6]. Reduced concentrations of polyunsaturated fatty acids, vitamin A, vitamin E and selenium may also be associated with enhanced oxidative stress, and indeed several investigators have found reduced concentrations of these parameters in HIV infection [7][8][9]; others have found normal or even increased levels [10,11]. HIV infection is also reported to be associated with systemic deficiency of glutathione (GSH), and the importance of this finding for the pathogenesis of this infection has received wide attention [12,13].…”

mentioning

confidence: 71%