Serum Trace Element Concentrations in Rheumatoid Arthritis

Abstract

Rheumatoid arthritis (RA) is a condition that is associated with oxidative stress. Serum trace elements and their related transport proteins, e.g., albumin and ceruloplasmin, play an important role in the antioxidant defense. Trace element status may therefore be involved in the pathogenesis of RA or be affected by the disease activity of this chronic inflammatory condition. The study participants were 110 patients with RA and 100 sex- and age-matched healthy volunteers. Serum concentrations of albumin, ceruloplasmin, selenium, zinc, copper, and zinc/copper ratio were measured in all subjects. The relationship between these parameters and disease activity score was also assessed. Lower concentrations of serum Alb, Zn, and Se were independently related to disease activity index. High concentrations of serum copper were associated with the presence of RA. Serum Cu concentrations were positively related to disease activity as assessed by the disease activity score. Low serum concentrations of Zn and Se, and high serum Cu concentrations may be associated with the presence of RA or be a consequence of this condition. Of the trace elements that were investigated in the present study, only serum Cu was positively correlated with disease activity.

Effect of Oxidative Stress on Iraqi Rheumatoid Arthritis Patients

“…So the decrease in serum albumin level obtained in the present study could be explained by either that albumin is one of the negative acute phase proteins that decreased after inflammations or due to its activity as antioxidant or both , as shown in the Fig. (2) The results obtained in the present study agree with [25] [26]. Serum Total bilirubin levels is significant decrease in compare to control group, as shown in the Fig.…”

The association between albumin‐dNLR score and disease activity in patients with rheumatoid arthritis

“…Derived neutrophil to lymphocyte ratio (dNLR) was defined as the neutrophil count to (leukocyte–neutrophil count) . Several evidences have demonstrated that systemic inflammation and malnutrition might be associated with disease activity of RA patients and might contribute to the pathogenesis and progression of RA . Circulating immune cells such as lymphocytes, neutrophils, and monocytes can reflect the severity of systematic inflammation .…”

“…3 Several evidences have demonstrated that systemic inflammation and malnutrition might be associated with disease activity of RA patients and might contribute to the pathogenesis and progression of RA. 4,5 Circulating immune cells such as lymphocytes, neutrophils, and monocytes can reflect the severity of systematic inflammation. 6 Albumin is a routine marker reflecting both nutritional status and systemic inflammation, while the synthesis of albumin can be suppressed by systematic inflammation and malnutrition.…”

Клініко-Патогенетична Значущість Остеоасоційованих Мікроелементів При Хворобах Суглобів. Повідомлення ІІ. Мікроелементоз У Волоссі

“…При всех изученных заболеваниях суставов установлены нарушения микроэлементного состава крови, которые участвуют в патогенетических механизмах артритов и определяют их клиническое течение. Микроэлементоз рассматривается как одно из важных клинико-патогенетических составляющих дегенеративно-воспалительных болезней суставов [6,11,17].…”