Serum Total Sialic Acid and Acute Phase Proteins in Elderly Subjects

Abstract

Serum total sialic acid has gained recent interest äs a cardiovascular risk factor. We measured serum total sialic acid and three acute phase proteins; C-reactive protein, a r antichymotrypsin and <x r acid glycoprotein in 37 geriatric patients (age 80.1 ± 7.0 years) and 50 younger subjects (age 40.3 ±11.4 years). Serum total sialic acid was higher in the geriatric subjects 2.41 ± 0.39 mmol/1 versus 2.04 ± 0.35 mmol/1, P < 0.04. Serum {-acid glycoprotein, cti-antichymotrypsin and C-reactive protein were also elevated in the geriatric patients; serum a!-acid glycoprotein being 1.16 ± 0.32 g/l versus 0.41 ± 0.28 g/l, P < 0.0001, serum a r antichymotrypsin being 0.80 ± 0.20 g/l versus 0.52 ± 0.10 g/l, P < 0.0001 and serum C-reactive protein being 9.71 ± 21.0 mg/1 versus 4.73 ± 1.30 mg/1, P < 0.04. There was a correlation with serum total sialic acid and serum a r acid glycoprotein and a r antichymotrypsin in the geriatric subjects and with-acid glycoprotein, a r antichymotrypsin and C-reactive protein in the younger group.

Role of serum total sialic acid in differentiating cholangiocarcinoma from hepatocellular carcinoma

“…One possible explanation is that, in certain cancers, increased activity of sialytransferase might lead to spontaneous shedding of aberrant sialic acid-containing cell surface glycoconjugates into the circulation [16] . Alternatively, since TSA has been well described as being associated with the acute-phase protein response [17] , increased activity of serum or tissue sialidase in combination with inflammatory response could considerably elevate serum TSA levels in patients with CCA. Also, the difference between the ages of the CCA and HCC groups might be responsible for this discrepancy, since serum TSA concentration slightly increased with advancing age [18] .…”

Study of the interaction of artemisinin with bovine serum albumin

“…Change in protein binding is usually clinically imperial in drug therapy. Alteration in serum albumin binding occurs not only in the elderly [35,36], but also in disease state [37]. The chemical changes that irradiation causes in protein are fragmentation, cross-linking, aggregation, and oxidation by radicals generated in the radiolysis of water [38][39][40][41].…”

Sialic acid in cardiovascular diseases

“…Later on, many studies came up showing that serum sialic acids were elevated in cardiovascular diseases (3)(4)(5)(6)(7)(8)(9)(10). Serum sialic acid levels correlated with carotid atherosclerosis, independently of major cardiovascular risk factors (26).…”