Serum total oxidant and antioxidant status in earthquake survivors with post-traumatic stress disorder

Özdemir, Pınar Güzel; Kaplan, İbrahim; Uysal, Cem; Bulut, Mahmut; Atlı, Abdullah; Bez, Yasin; Kaya, Mehmet Cemal; Özdemir, Osman

doi:10.1017/neu.2014.47

Cited by 4 publications

(5 citation statements)

References 31 publications

(34 reference statements)

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“…As part of a magnetic resonance spectroscopy (MRS) study, Michaels et al (48) examined the dorsolateral prefrontal cortex and anterior cingulate cortex among 29 trauma-exposed individuals (12 with PTSD and 17 without PTSD), and found those with PTSD had significantly higher levels of the antioxidant, glutathione in both regions, which may represent a compensatory reaction to increased oxidation (it may also represent an excess of antioxidant activity for unclear reasons). Ozdemir et al (49) recently reported a lack of significant group differences in total antioxidant or oxidative status among Turkish earthquake survivors with and without PTSD, and also did not find significant correlations between severity of PTSD symptoms and oxidative measures. Overall, the results from studies of PTSD and oxidative markers appear mixed at best, but given the limited availability of studies with overlapping methods or outcomes measures, and the small samples sizes within several of the available studies, it seems premature to draw firm conclusions regarding the presence or absence of an association of PTSD with oxidative stress.…”

Section: Resultsmentioning

confidence: 96%

“…We found five studies relevant to PTSD and oxidative measures (18, 46–49). Tezcan et al (18) compared 14 people with PTSD and 14 hospital staff used as comparison subjects.…”

Section: Resultsmentioning

confidence: 99%

“…The results for oxidative stress were equivocal as only five studies were recovered and the methods and outcomes were too diverse to permit firm conclusions about the presence or absence of an association of PTSD with oxidative stress (18, 46–49), although there are theoretical reasons to expect such an association (45). Pooled effect sizes of LTL and pro-inflammatory biomarkers were generally consistent with an association of PTSD with senescent-like changes.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Is Post-Traumatic Stress Disorder Associated with Premature Senescence? A Review of the Literature

Lohr

Palmer

Eidt

et al. 2015

The American Journal of Geriatric Psychiatry

203

148

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Post-Traumatic Stress Disorder (PTSD) has major public health significance. Evidence that PTSD may be associated with premature senescence (early or accelerated aging) would have major implications for quality of life and healthcare policy. We conducted a comprehensive review of published empirical studies relevant to early aging in PTSD. Our search included the PubMed, PsycINFO and PILOTS databases for empirical reports published since the year 2000 relevant to early senescence and PTSD, including: (1) biomarkers of senescence (leukocyte telomere length (LTL) and pro-inflammatory markers), (2) prevalence of senescence-associated medical conditions, and (3) mortality rates. All six studies examining LTL indicated reduced LTL in PTSD (pooled Cohen’s d = 0.76). We also found consistent evidence of increased pro-inflammatory markers in PTSD (mean Cohen’s ds), including C-reactive protein = 0.18, Interleukin-1 beta = 0.44, Interleukin-6 = 0.78, and tumor necrosis factor alpha = 0.81. The majority of reviewed studies also indicated increased medical comorbidity among several targeted conditions known to be associated with normal aging, including cardiovascular disease, type 2 diabetes mellitus, gastrointestinal ulcer disease, and dementia. We also found seven of 10 studies indicated PTSD to be associated with earlier mortality (average HR = 1.29). In short, evidence from multiple lines of investigation suggests that PTSD may be associated with a phenotype of accelerated senescence. Further research is critical to understand the nature of this association. There may be a need to re-conceptualize PTSD beyond the boundaries of mental illness, and instead as a full systemic disorder.

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Section: Resultsmentioning

confidence: 96%

“…We found five studies relevant to PTSD and oxidative measures (18, 46–49). Tezcan et al (18) compared 14 people with PTSD and 14 hospital staff used as comparison subjects.…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Is Post-Traumatic Stress Disorder Associated with Premature Senescence? A Review of the Literature

Lohr

Palmer

Eidt

et al. 2015

The American Journal of Geriatric Psychiatry

203

148

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“…Özdemir et al [ref#? ] did not find a significant difference in total oxidant and antioxidant parameters in their study with adults with post-traumatic stress disorder; however, a significant difference in lipid peroxidation markers and prolidase among sub-parameters was found in other studies [43][44][45]. These data led us to understand the functional neurological disorder better, and assessing oxidative stress sub-parameters might be more useful before the deterioration of oxidative capacity affects total antioxidant capacity.…”

Section: Discussionmentioning

confidence: 82%

The role of oxidative stress levels and S100B levels in children with functional neurological disorder

Sizer,

Çobanoğlu,

Kaplan

2023

J Surg Med

Self Cite

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Background/Aim: Although stressors and traumatic life events are known to be predisposing factors for developing functional neurological disorder (FND), the etiology of the disorder has not been fully elucidated. In this study, oxidative stress parameters and serum levels of S100B protein were investigated in pediatric patients with functional neurological disorder. The association of these parameters with stress factors and traumatic life events was investigated. Methods: This case-control study included a control group of 35 patients aged 8-18 years and 32 healthy subjects diagnosed with functional neurological disorder. The Childhood Trauma Scale and Dissociative Experiences Scale were applied to both groups. Serum levels of the patient and control groups were compared by blood sampling: total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and S100B. Results: It was found that the Childhood Trauma Scale total score, emotional neglect, emotional abuse, physical neglect and the Dissociative Experiences Scale were statistically significantly higher in the FND group than in the control group (P˂0.001, P˂0.001, P=0.013, P=0.017, P˂0.001). Stressors were found to be statistically significantly higher in the FND group than in the control group (P=0.020). There was no statistical difference between the FND group and control groups regarding the TAS, TOS, OSI, and S100B levels (P=0.965, P=0.228, P=0.268, P=0.517, respectively). Conclusion: Our study is the first to investigate TOS, TAS, OSI and S100B in children with FND. In our study, although stressors and traumatic experiences were significantly higher in the functional neurological disorder group compared to the control group according to the stress susceptibility model, contrary to expectations, there was no significant difference in oxidative stress parameters and serum S100B levels. It was thought that the interaction between FND, which is characterized by biopsychosocial interaction and can manifest itself with various clinical symptoms, and stress may not be linear as initially thought, and the interaction between genetic predisposition and environmental factors may play a more complex role. The absence of significant differences observed in oxidative stress parameters and serum S100B levels may suggest that we should focus on different pathways and different potential biomarkers that need to be investigated in the future to understand the etiology and diagnosis of FND. However, the limitations noted above may affect the generalizability of the study findings.

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“…Of course, there are still a lot of controversies regarding the relevance of the oxidative stress status in most of the affective disorders and despite the fact that most of the studies are showing that the affective disorders development can be correlated to increased oxidative levels (as we showed for most of the shortly described studies above), there are also some distinct studies reporting that oxidative stress may not be linked in any way, for example, with PTSD [ 57 , 58 ].…”

Section: Introductionmentioning

confidence: 91%

Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches

Balmus

Ciobîcă

Antioch

et al. 2016

Oxidative Medicine and Cellular Longevity

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The correlation between the affective disorders and the almost ubiquitous pathological oxidative stress can be described in a multifactorial way, as an important mechanism of central nervous system impairment. Whether the obvious changes which occur in oxidative balance of the affective disorders are a part of the constitutive mechanism or a collateral effect yet remains as an interesting question. However it is now clear that oxidative stress is a component of these disorders, being characterized by different aspects in a disease-dependent manner. Still, there are a lot of controversies regarding the relevance of the oxidative stress status in most of the affective disorders and despite the fact that most of the studies are showing that the affective disorders development can be correlated to increased oxidative levels, there are various studies stating that oxidative stress is not linked with the mood changing tendencies. Thus, in this minireview we decided to describe the way in which oxidative stress is involved in the affective disorders development, by focusing on the main oxidative stress markers that could be used mechanistically and therapeutically in these deficiencies, the genetic perspectives, some antioxidant approaches, and the relevance of some animal models studies in this context.

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Serum total oxidant and antioxidant status in earthquake survivors with post-traumatic stress disorder

Abstract: Our results suggest that the total oxidant and antioxidant status may not affect earthquake survivors with PTSD. This is the first study to evaluate the oxidative status in earthquake survivors with PTSD. Further studies are necessary to confirm these findings.

Cited by 4 publications

References 31 publications

Is Post-Traumatic Stress Disorder Associated with Premature Senescence? A Review of the Literature

Is Post-Traumatic Stress Disorder Associated with Premature Senescence? A Review of the Literature

The role of oxidative stress levels and S100B levels in children with functional neurological disorder

Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches

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