Serum Total Homocysteine and Coronary Heart Disease

Arnesen, Egil; Refsum, Helga; Bønaa, Kaare Harald; Ueland, Per Magne; Førde, Olav Helge; Nordrehaug, Jan Erik

doi:10.1093/ije/24.4.704

Cited by 582 publications

(262 citation statements)

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“…Interestingly, in a recent Norwegian study, it was shown a positive linear association between plasma tHcy levels and total serum cholesterol (Nyga Êrd et al, 1995). Other studies have shown similar results, but no biochemical explanation for this association has been presented (Arnesen et al, 1995;Messer, 1986;Molgaard et al, 1992;Wu et al, 1994).…”

Section: Discussionmentioning

confidence: 86%

“…There is increasing evidence that elevated levels of plasma total homocysteine (tHcy) is an independent risk factor for cardiovascular diseases (Arnesen et al, 1995;Boushey et al, 1995;Malinov, 1994;Nyga Êrd et al, 1995;Nyga Êrd et al, 1997a;Perry et al, 1995;Stampfer et al, 1992;Ueland et al, 1992). Low levels of the vitamins folate, cobalamin and B-6 have been shown to be related to elevated levels of tHcy (Ubbink et al, 1993;Selhub et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

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Diet, an independent determinant for plasma total homocysteine. A cross sectional study of Norwegian workers on platforms in the North Sea

1998

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Objective: To examine whether diet is an independent determinant for total homocysteine (tHcy) levels. Design: Data on background variables was collected by questionnaire interviews, food intake by one 24 h recall and tHcy levels in a blood sample in 310 healthy men (mean age, 38 y). Setting: Two oil producing platforms in the Norwegian sector in the north sea. Results: The arithmetic mean (s.d.) and median tHcy levels were 10.4 (2.9) mmolaL and 9.9 mmolaL, respectively. In a covariance analysis, mean adjusted plasma tHcy decreased by 7±21% from no intake to highest category of intake of bread, vegetables, and skimmed milk, and increased by 8±9% from less than 30% to above 35% energy from fat, and from no intake to one liter or more for coffee. Smokers had a lower intake of cereals, bread vegetables and fruits, but ate more fat and meat. Thus, smoking may have an indirect effect on the tHcy level through its effect on diet. In a multiple regression model, bread and vegetables were negatively associated with tHcy, while fat was positively associated. Conclusions:The results suggest that changes in diet may be an important means to lower the tHcy level in the overall population, and that dietary advice should be considered in subjects diagnosed with elevated tHcy levels. Sponsorships: Norwegian State Oil Company (STATOIL), Amoco

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Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Diet, an independent determinant for plasma total homocysteine. A cross sectional study of Norwegian workers on platforms in the North Sea

1998

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“…13 There are additional concerns regarding unmeasured and residual confounding due to dietary and other lifestyle factors associated with hyperhomocysteinaemia. 14,15 The findings from the small number of prospective studies that have addressed associations between tHcy concentrations and incident coronary heart diseases (CHD) or stroke are inconsistent [16][17][18][19][20][21][22] Homozygosity for a defective thermolabile variant of MTHFR, a common genetic polymorphism which results in hyperhomocysteinemia, has not been consistently linked with cardiovascular disease endpoints. 23,24 Although the importance of gene markers will vary depending on relevant environmental exposures, diet in this instance, the findings from gene association studies conducted to-date are distinctly unimpressive.…”

Section: Thcy and Cardiovascular Diseasementioning

confidence: 99%

Homocysteine, hypertension and stroke

Perry

1999

J Hum Hypertens

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The balance of evidence from observational studies suggests that elevated homocysteine levels are associated with increased risk of carotid artery disease and stroke. There is however a paucity of prospective studies. There are also concerns regarding confounding due to factors associated with hyperhomocysteinemia, including renal impairment, an atherogenic diet and cigarette smoking. Homozygosity for a defective thermolabile variant of MTHFR, a common genetic polymorphism which results in hyperhomocysteinemia, has not been consistently linked with stroke or other vascular disease. There is a need for additional prospective studies with data on relevant confounders, sufficient power to characterise the form of the association between homocysteine concentrations and stroke risk, whether linear or threshold, and power to study interactions between homocysteine, other dietary markers and established stroke risk factors such as smoking and

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“…Semelhante a estudos prévios, a concentração sérica de homocisteína total apresentou correlações positivas significantes com os níveis de pressão arterial (41,43) e com as concentrações séricas de triglicérides (44) e de ácido úrico (45). A função renal, que é um determinante importante dos níveis de homocisteína (16), foi avaliada neste estudo através da medida dos níveis de creatinina sérica, que não apresentaram alterações.…”

Section: Discussionunclassified

Relação da homocisteinemia com a sensibilidade à insulina e com fatores de risco cardiovascular em um grupo indígena brasileiro

Tavares

Vieira-Filho

Andriolo

et al. 2002

Arq Bras Endocrinol Metab

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RESUMOA hiper-homocisteinemia é um fator de risco cardiovascular independente. Há controvérsias sobre uma possível relação entre a homocisteína e a resistência/sensibilidade à insulina. Para testar a relação entre a homocisteinemia e a sensibilidade à insulina, noventa índios Parkatêjê (90% da população adulta, sem miscigenação) tiveram os níveis séricos de homocisteína total (HPLC) dosados. A sensibilidade à insulina (%S) foi calculada pelo HOMA. Uma índia diabética foi excluída das análises envolvendo glicemia, insulina, pró-insulina, HbA1c e %S. Hiper-homocisteinemia e hiperinsulinemia ao jejum foram encontradas em 26,7% e 25,8% dos índios, respectivamente. O logaritmo natural (ln) da homocisteína correlacionou-se positivamente com a pressão arterial sistólica (r= 0,22) e diastólica (r= 0,21), triglicérides (r= 0,39) e ácido úrico (r= 0,40), após ajuste para idade e sexo, mas não com a insulina, pró-insulina e ln %S. O ln da homocisteína foi semelhante em todos os quartis de %S e também entre os indivíduos com e sem hiperinsulinemia de jejum. A insulina, pró-insulina e ln %S foram semelhantes entre os indivíduos com e sem hiper-homocisteinemia. Observamos correlações entre variáveis relacionadas ao risco cardiovascular, mas não entre essas variáveis e a insulina ou o ln %S. Este achado talvez seja peculiar deste grupo. Concluindo, as variações nas concentrações séricas da homocisteína não estão relacionadas à insulina, à pró-insulina e à %S entre os Parkatêjê. Hyperhomocysteinemia is an independent cardiovascular risk factor. There are controversies about a possible relation between homocysteine and insulin resistance/sensitivity. To test the relation between homocysteinemia and insulin sensitivity, serum total homocysteine concentrations (HPLC) were measured in samples from ninety Parkatêjê Indians (90% of the adult population, without admixture). Insulin sensitivity (%S) was estimated by HOMA. A diabetic woman was excluded from the analysis involving glycaemia, insulin, proinsulin, HbA1c and %S. Hyperhomocysteinemia and fasting hyperinsulinemia were found in 26.7% and 25.8% of Indians, respectively. Log-transformed (ln) homocysteine was positively correlated with systolic (r= 0.22) and diastolic (r= 0.21) blood pressure, triglycerides (r= 0.39) and uric acid (r= 0.40), after adjustment for age and sex, but not with insulin, proinsulin and ln %S. Ln homocysteine was similar among the quartiles of %S and between the subjects with and without fasting hyperinsulinemia. Insulin, proinsulin and ln %S were similar between the subjects with and without hyperhomocisteinemia. Correlations between variables related to cardiovascular risk were observed, but not between these variables and insulin or ln %S. Perhaps this finding could be a peculiar characteristic of this group. In conclusion, the artigo originalRelação da Homocisteinemia com a Sensibilidade à Insulina e com Fatores de Risco Cardiovascular em Um Grupo Indígena Brasileiro

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Serum Total Homocysteine and Coronary Heart Disease

Abstract: In the general population serum total homocysteine is an independent risk factor for CHD with no threshold level.

Cited by 582 publications

References 0 publications

Diet, an independent determinant for plasma total homocysteine. A cross sectional study of Norwegian workers on platforms in the North Sea

Diet, an independent determinant for plasma total homocysteine. A cross sectional study of Norwegian workers on platforms in the North Sea

Homocysteine, hypertension and stroke

Relação da homocisteinemia com a sensibilidade à insulina e com fatores de risco cardiovascular em um grupo indígena brasileiro

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