Serum total estriol in abnormal newborn infants

Reynolds, John W.; Bentley, Karen L. de Mesy; Turnipseed, Marvin R.

doi:10.1016/0022-4731(77)90094-2

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…(I), and Dickey and Robertson (2) (subnormal urinary E3 levels). On the other hand, a statistically significant association between estrogens in blood and RDS has not been observed by some groups of investigators (7,8,10). We believe that such negative findings are explainable and, moreover, could have been anticipated.…”

Section: Discussionmentioning

confidence: 64%

“…We believe that such negative findings are explainable and, moreover, could have been anticipated. In one such study, peripheral venous samples of blood were obtained from newborns during the first 24 h of life and analyzed for total E3 (8). The control group for this study was composed of severely ill newborns who were cared for in the intensive care nursery; many of these newborns had "benign respiratory distress," not normal lung function.…”

Section: Discussionmentioning

confidence: 99%

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Ontogeny of Unconjugated Estriol in Fetal Blood and the Relation of Estriol Levels at Birth to the Development of Respiratory Distress Syndrome

et al. 1987

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ABSTRAa. Unconjugated estriol (E3) was quantified in E2, estradiol serum of umbilical cord blood of 533 newborn infants, 360 E3, estriol of whom were delivered between 23 and 37 wk of gestation.CS, cesarean section Serum E3 levels rose (F = 7.71, p < 0.0001) as a function DS, dehydroepiandrosterone sulfate of gestational age; the mean concentration of E3 at 37.5-42 wk of gestation (105 ng/ml, n = 173) was significantly higher than that in serum of newborns delivered at 23-28 wkY of gestation (63 ng/ml, n = 33). Umbilical cord serum levels of E3 were significantly higher among newborns delivered vaginally between 31.5 and 42 wk of gestation than among newborns delivered by cesarean section ( p < 0.005). Although serum E3 levels correlated highly ( p < 0.0001) to newborn weight throughout the entire period of gestation, there was no relationship of newborn weight to umbilical serum E3 levels within a given gestational period. Also, the umbilical serum levels of E3 in male infants were similar to those of female infants at each gestational age. Significant changes in umbilical serum levels of E3 as a function of gestational age were not observed among newborns (n = 90) who developed respiratory distress syndrome (RDS). The mean umbilical serum concentration of E3 in newborns delivered at 34.5-37 wk of gestation who developed RDS were significantly lower ( p < 0.01) than that in similar aged newborns whose lung function was normal. Based on the results of multiple logistic regression analyses, we estimated that for each week between 28.5-36 wk of gestation, the probability of RDS in infants in whom the E3 level was at the 10th percentile was about 7% greater than that in newborns in whom the E3 level was at the 50th percentile; the probability of RDS in infants with an E3 level at the 90th percentile was about 10% lower than that in newborns in whom the E3 level was at the 50th percentile. These data are suggestive that with normal intrauterine development, fetal tissues are exposed to unconjugated E3 in progressively increasing concentrations during the latter half of gestation. When fetal levels of E3 do not increase during this critical period of development, there is an increased risk of development of RDS. (Pediatr Res 21: 386-390, 1987)

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Section: Discussionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Ontogeny of Unconjugated Estriol in Fetal Blood and the Relation of Estriol Levels at Birth to the Development of Respiratory Distress Syndrome

et al. 1987

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“…The procedure for radioimmunoassay for DHAS (Turnipseed et al 1976) and total oestriol (Reynolds et al 1977) in this laboratory has been published elsewhere. Two tailed Student's paired /-test was used for all the statistical analyses.…”

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confidence: 99%

Umbilical serum DHAS and total oestriol in relation to gestational age and mode of delivery

Noguchi

Turnipseed

Bentley

et al. 1980

Acta Endocrinologica

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The concentrations of mixed umbilical cord serum dehvdroepiandrosterone sulphate (DHAS) and total oestriol, were determined by radioimmunoassay in 301 infants. Of 280 infants born between 36 and 42 weeks of gestation, 260 were born by vaginal delivery and 20 were delivered by Caesarean (C-section). We found that there was a significant elevation of serum total oestriol (P < 0.005) after 35 weeks with no concomitant gestational change of DHAS. Within the vaginal delivery group steroid values were similar among infants born following spontaneous, oxytocin augmented, and oxytocin induced labour. Within the C-section delivery group, steroid values were similar in infants who experienced spontaneous labour and those who did not. However, DHAS level was significantly higher (P < 0.005) in the vaginal delivery group than in the C-section group. We postulate that the higher DHAS levels in the vaginal delivery group are the result of stress during the late first stage of labour or later.The endocrine activity of the foeto-placental unit change remarkably in the last several weeks of normal pregnancy. These late gestation foetal adrenal functional changes have been postulated to play a role in the onset of labour in the human (Murphy 1973;Turnbull et al. 1974). Foetal adrenal weight increases rapidly after 34 weeks (Spector 1956) and corticosteroid in foetal blood (Smith et al. 1975) as well as free and conjugated cortisol in the amniotic fluid (Montserrat & Tulchinsky 1975) increase progressively after 36 weeks. In the maternal circulation, oestradiol-17ß (Turnbull et al. 1974; Shutt et al. 1974) and oestriol (Shutt et al. 1974;Buster et al. 1976) levels increase at about 36 weeks and this oestrogen surge has been attributed to increased production of dehydroepiandrosterone sulphate (DHAS) by the foetal adrenal gland. To further assess this change of oestrogen levels in the third trimester, and to relate the change to oestrogen precursor levels, we measured DHAS and total (conjugated and unconjugated) oestriol in cord blood samples from a large number of patients. In addition, we examin¬ ed the relationship of these two steroids to the presence or absence of labour.Patients and Methods I hreehundred and ten umbilical cord blood samples were obtained at 308 consecutive deliveries at St. Paul Ramsey Countv Hospital. At delivery, foetal and placen¬ tal sides of the cord were clamped and the blood was allowed to drain into the tubes from the placental end. This procedure vielded mainly umbilical venous blood.The blood was centrifuged after clotted and the serum was kept frozen until the time of assay. The gestational age of the infants was determined from the date of the Reprint requests to:

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Development and Function of the Human Fetal Adrenal Cortex,

Reynolds

1981

Fetal Endocrinology

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Serum total estriol in abnormal newborn infants

Cited by 5 publications

References 16 publications

Ontogeny of Unconjugated Estriol in Fetal Blood and the Relation of Estriol Levels at Birth to the Development of Respiratory Distress Syndrome

Ontogeny of Unconjugated Estriol in Fetal Blood and the Relation of Estriol Levels at Birth to the Development of Respiratory Distress Syndrome

Umbilical serum DHAS and total oestriol in relation to gestational age and mode of delivery

Development and Function of the Human Fetal Adrenal Cortex,

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