Serum total cholesterol, high-density lipoprotein-cholesterol and triglyceride concentrations in lambs following supplementation with various forms of tocopherol

Abstract

Summary &horbar; A 61-d study involving 40 crossbred lambs evaluated the effect of various forms of tocopherol provided daily in equimolar amounts on total cholesterol, high-density lipoproteincholesterol and triglyceride concentrations in the serum of lambs. Thirty-five lambs were allotted to 7 treatment groups of 5 animals each, supplemented with 300 mg tocopherol either as: 1) DL -atocopheryl acetate; 2) D -a-tocopheryl acetate; 3) D-<x-tocopheryl succinate; 4) D -a-tocopheryl polyethylene glycol 1 000 succinate (TPGS); 5) DL -a-tocopheryl nicotinate; 6) DL -a-tocopheryl nicotinate (150 mg) + 150 mg TPGS; and 7-D -a-tocopheryl acetate (150 mg) + 150 mg TPGS mixed with the commercial flock diet. In addition, another group of 5 lambs were used as control (no vitamin E supplementation). Dietary supplementation of various vitamin E sources resulted in no overall treatment effects for total cholesterol, triglycerides or high density lipoprotein-cholesterol. A significant variation was noticed among animals. The levels of all measured serum components varied throughout the experimental period (P < 0.0001 The day x treatment interaction was not significant (P > 0.05) for any serum measured component. The present data strongly suggest that short-term treatment (< 2 mo) with pharmacological oral doses of various forms of vitamin E did not influence serum lipid metabolism of lambs. The data also showed that the bioavailability of cc-tocopherol is dependent on the form administered. D -a-tocopherol acetate is a highly available form, the bioavailability of which is further increased when combined with o-a-tocopheryl polyethylene glycol succinate.

The influence of dietary vitamin E, fat, and methionine on blood cholesterol profile, homocysteine levels, and oxidizability of low density lipoprotein in the gerbil

“…In a sheep study, no observed influence on plasma cholesterol, triglycerides or total lipids following the provision of varying doses of vitamin E for 3 months [41]. Similar findings with regards to lipid and cholesterol plasma profile were reported by Hidiroglou et al [42] in lambs ingesting various forms of vitamin E during a 60-day period. Discrepancies on the effect of vitamin E on plasma lipid profile may be associated to the extent of dosing time with the antioxidant [43] and these investigators [43] suggest that changes in serum lipoprotein profile may occur after receiving the antioxidant nutrient for more than 3 months.…”

Vitamin E Nicotinate

“…Hidiroglou et al [40] examined the effects of different tocopherol esters on serum concentrations of triglycerides, total cholesterol, and high-density lipoprotein (HDL)-cholesterol in 40 wether lambs. The animals were divided into seven treatment groups of five animals each and one placebo group.…”

Effects of calcium soap of rice bran oil fatty acids supplementation alone and with DL‐α‐tocopherol acetate in lamb diets on performance, digestibility, ruminal parameters and meat quality

“…Nonetheless, the observed values were within the normal range reported for sheep (Kaneko et al., ). Additional α ‐tocopherol in T 3 was intended at improving the carcass quality, and thus, it may not influence serum lipid metabolism in this short‐term intervention (Hidiroglou et al., ).…”