Serum Total Antioxidant Status, Lipid Profile, Malondialdehyde and Erythrocyte Superoxide Dismutase Levels in Hashimoto Thyroiditis Patients Treated with Levothyroxine

Mehmetçik, Güldal; Becer, Eda; Akbey, Aylin

doi:10.5336/medsci.2011-25866

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…In the current study, NP-SH was significantly reduced by 12 months of LRT, but no significant changes were observed in T-SH, δ-ALA-D or TBARS. Some studies have shown reduction of oxidative stress after LRT, [ 18 , 23 , 29 ], while other studies have reported no modification [ 19 , 20 ]. Marfella et al [ 26 ] detected elevated OS biomarkers in atherosclerotic plaques of SCH subjects compared to control plaques, and higher levels of OS in plaques of untreated SCH patients in comparison with plaques of treated SCH patients.…”

Section: Discussionmentioning

confidence: 99%

Improvement of blood inflammatory marker levels in patients with hypothyroidism under levothyroxine treatment

et al. 2015

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BackgroundThere are several specific inflammatory and oxidative correlates among patients with hypothyroidism, but most studies are cross-sectional and do not evaluate the change in parameters during the treatment. The aim of this study was to investigate the effect of levothyroxine replacement therapy on biomarkers of oxidative stress (OS) and systemic inflammation in patients with hypothyroidism.MethodsIn this prospective open-label study, 17 patients with recently diagnosed primary hypothyroidism due to Hashimoto’s thyroiditis who were not taking levothyroxine were included. The following parameters were measured before and at 6 and 12 months of levothyroxine treatment with an average dose of 1.5 to 1.7 μg/kg/day: thyroid-stimulating hormone (TSH), free thyroxine (FT4), high-sensitivity C-reactive protein (hs-CRP), interleukin 1 (IL-1), IL-6, IL-10, interferon gamma (INF-γ), tumor necrosis factor alpha (TNF-α), thiobarbituric acid-reactive substances (TBARS), activity of aminolevulinic acid dehydratase (δ-ALA-D), nonprotein and total thiol (NP-SH and T-SH) groups, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG). Generalized estimating equation (GEE) modeling was used to analyze the effects of LRT (at pre-treatment, 6 months and 12 months) on those variables. The hypothyroidism status (i.e., overt or subclinical hypothyroidism) was included as a confounder in all analyses. An additional GEE post hoc analysis was made to compare time points.ResultsThere was a significant decrease in TSH over time (P < 0.0001), (initial levels were on average 32.4 μIU/mL and 10.5 μIU/mL at 12 months). There was a significant increase in FT4 (P < 0.0001) (initial levels were on average 0,8 ng/dL and 2.7 ng/dL at 12 months). There were significant changes in interleukin levels over time, with a significant increase in IL-10 (P < 0.0001) and significant decreases in IL-1 (P < 0.0001), IL-6 (P < 0.0001), INF-γ (P < 0.0001) and TNF-α (P < 0.0001). No significant difference in hs-CRP over time was observed (P < 0.284). There was a significant reduction in NP-SH (P < 0.0001).ConclusionsThis study observed significant changes in the inflammatory profile in hypothyroid patients under treatment, with reduction of pro-inflammatory cytokines and elevation of anti-inflammatory cytokine. In these patients, a decrease in low-grade chronic inflammation may have clinical relevance due to the known connection between chronic inflammation, atherosclerosis and cardiovascular events.

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Section: Discussionmentioning

confidence: 99%

Improvement of blood inflammatory marker levels in patients with hypothyroidism under levothyroxine treatment

et al. 2015

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“…For the five thyroid function parameters, there were strong positive correlations among TSH, T4, T3, FT3, and FT4 (r=0.4-0.8, P<0.01), which could be explained by T3 being the more metabolically active hormone produced by T4. T4 is deiodinated by three deiodinase enzymes and produces the more active T3 (42). Nevertheless, no correlations were observed between concentrations of total PBDEs to age or BMI (P>0.05).…”

Section: Spearman's Correlation Between Total Pbde Concentration and Thyroid Function Parametersmentioning

confidence: 96%

The potential association of polybrominated diphenyl ether concentrations in serum to thyroid function in patients with abnormal thyroids: a pilot study

Yang¹,

Yan-chun²,

Zhang³

et al. 2021

Ann Palliat Med

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Background: To explore possible associations between polybrominated diphenyl ether (PBDE) exposure and patients with abnormal thyroid hormone levels whose thyroid function parameters are above normal ranges.Methods: The serum of 40 patients with thyroid hormone abnormalities was collected in Kunming. triiodothyronine (T3), thyroxine (T4), free triiodothyronine (FT3), free thyroxine (FT4), and thyroidstimulating hormone (TSH) were detected in serum using chemiluminescence. The PBDE homologs in the patients' serum were quantitatively analyzed by gas chromatography-mass spectrometry. If the detection frequency of the compound exceeded 50%, it was included in the analysis. Spearman's rank correlation coefficient and multiple linear regression were used to evaluate the correlation between PBDE homologs and five thyroid function parameters.Results: A total of 33 PBDE homologs were detected, 7 of which had a more than 50% detection rate. BDE-47 was the main homolog detected. Spearman's correlation showed that no relationship was found between PBDE homologs and thyroid hormones. Multiple linear regression showed that BDE-153 was positively correlated with T4, negatively correlated with T3, while BDE-47 was negatively correlated with FT4 (P<0.05). The correlation between other PBDE homologs and thyroid function parameters was weak (P>0.05). The β coefficient showed that the increase in the logarithmic unit of ∑ 7 PBDEs was related to an increase in FT4 and T4 levels and decreased TSH, T3, and FT3 levels.Conclusions: There is a significant correlation between exposure to PBDE and thyroid dysfunction. The increase of total PBDEs was significantly correlated with the increase of FT4 and T4 levels and decreased TSH, T3, and FT3 levels.

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Serum Total Antioxidant Status, Lipid Profile, Malondialdehyde and Erythrocyte Superoxide Dismutase Levels in Hashimoto Thyroiditis Patients Treated with Levothyroxine

Cited by 2 publications

References 21 publications

Improvement of blood inflammatory marker levels in patients with hypothyroidism under levothyroxine treatment

Improvement of blood inflammatory marker levels in patients with hypothyroidism under levothyroxine treatment

The potential association of polybrominated diphenyl ether concentrations in serum to thyroid function in patients with abnormal thyroids: a pilot study

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