Serum total amylase, pancreatic amylase and lipase activities in epileptic children treated with sodium valproate monotherapy

Voudris, Konstantinos; Attilakos, Achilleas; Katsarou, Eustathia; Mastroyianni, Sotiria; Dimou, Stamatia; Skardoutsou, Angeliki; Prassouli, Alexia; Garoufi, Anastasia

doi:10.1016/j.braindev.2006.04.002

Cited by 11 publications

(11 citation statements)

References 14 publications

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“…Thus, our results confirm the previous conclusion that non-specific hyperamylasemia does not correlate with pancreatitis [7,8,21,22]. It is possible that nonpancreatic isoenzymes levels of amylase, probably derived from salivary glands, were increased in those asymptomatic patients [9,23].…”

Section: Discussionsupporting

confidence: 91%

“…In their prospective study on a group of children with epilepsy, Voudris et al [9] found no significant change of total amylase levels but demonstrated significant increase in non-pancreatic isoenzyme levels of amylase at 6 and 12 months of treatment, that was not correlated to VPA levels.…”

Section: Discussionmentioning

confidence: 95%

“…There are few data on serum lipase and pancreatic amylase levels in patients with VPA without clinical symptoms of pancreatitis. Voudris et al [9] and Hermida Ameijeiras et al [28] reported no effect of VPA on serum lipase. In our study, though the mean serum lipase level was increased in the patients com- pared to its levels in the control group, it exceeded the upper reference limit only in the five patients (11.1%).…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, it was reported that routine testing of serum total amylase levels has little predictive or diagnostic value in epileptic patients, as many patients receiving VPA who develop hyperamylasemia never develop pancreatitis [8]. So, the measurement of specific pancreatic amylase levels, particularly in conjunction with lipase levels, is recommended for the diagnosis of acute pancreatitis [9].…”

Section: Introductionmentioning

confidence: 99%

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Total amylase, pancreatic amylase and lipase levels in children with epilepsy on valproic acid

et al. 2015

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Acute pancreatitis associated with valproic acid (VPA) treatment is reported in literature. Amylases however are not specifically originated in the pancreas. Other organs, such as salivary glands, may be involved in causing higher serum activity. Thus, we aimed to investigate whether serum total amylase and particularly its pancreatic isoenzyme and lipase levels are altered in the course of treatment with VPA in children with epilepsy. The study was conducted on 45 children with epilepsy on VPA monotherapy. Trough serum VPA, serum total amylase, lipase, and pancreatic amylase levels were evaluated in the patients and results were compared to a matched control group. Though all patients were asymptomatic for acute pancreatitis, serum total amylase levels were elevated in 40%. Patients with increased levels of total amylase did not differ from the rest of patients regarding the characteristics of epilepsy syndrome or the degree of seizure control. Nevertheless, there was significant positive correlation between total amylase and VPA trough serum levels. Five patients had simultaneous elevation of total amylase, pancreatic isoenzyme and lipase levels, though in none of them reaching three folds the upper limit. They had no symptoms suggestive of acute or intermittent pancreatitis and their ultrasonic examination was normal. Follow up showed normalization of their serum levels. In conclusion, our results demonstrate the limited specificity of total amylase level as a marker for pancreatic injury. Whenever there is suspicion, a workup including pancreatic isoenzymes is advisable. The implication of asymptomatic elevation of pancreatic isoenzymes needs to be further investigated.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Total amylase, pancreatic amylase and lipase levels in children with epilepsy on valproic acid

et al. 2015

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“…The protein is of interest given that many antiepileptic drugs are potent enzyme inducers and inhibitors of the cytochrome P450 system, which affects lipid and glucose metabolisms, as well as evidence that increased lipase level is one of the side effects of anti-psychotic and anti-epileptic drugs (Voudris et al, 2004, 2006). Substitution of Leu to Val is quite favorable in all protein folding types (Xu et al, 2010), but Leu43Val in this protein is suspected to reduce protein stability (ΔΔG 2.06 kcal/mol).…”

Section: Resultsmentioning

confidence: 99%

SDS, a structural disruption score for assessment of missense variant deleteriousness

Preeprem

Gibson

2014

Front. Genet.

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We have developed a novel structure-based evaluation for missense variants that explicitly models protein structure and amino acid properties to predict the likelihood that a variant disrupts protein function. A structural disruption score (SDS) is introduced as a measure to depict the likelihood that a case variant is functional. The score is constructed using characteristics that distinguish between causal and neutral variants within a group of proteins. The SDS score is correlated with standard sequence-based deleteriousness, but shows promise for improving discrimination between neutral and causal variants at less conserved sites. The prediction was performed on 3-dimentional structures of 57 gene products whose homozygous SNPs were identified as case-exclusive variants in an exome sequencing study of epilepsy disorders. We contrasted the candidate epilepsy variants with scores for likely benign variants found in the EVS database, and for positive control variants in the same genes that are suspected to promote a range of diseases. To derive a characteristic profile of damaging SNPs, we transformed continuous scores into categorical variables based on the score distribution of each measurement, collected from all possible SNPs in this protein set, where extreme measures were assumed to be deleterious. A second epilepsy dataset was used to replicate the findings. Causal variants tend to receive higher sequence-based deleterious scores, induce larger physico-chemical changes between amino acid pairs, locate in protein domains, buried sites or on conserved protein surface clusters, and cause protein destabilization, relative to negative controls. These measures were agglomerated for each variant. A list of nine high-priority putative functional variants for epilepsy was generated. Our newly developed SDS protocol facilitates SNP prioritization for experimental validation.

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Current awareness: Pharmacoepidemiology and drug safety

2007

Pharmacoepidemiology and Drug

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 20 sections: 1 Reviews; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Teratogens/fetal exposure; 20 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Serum total amylase, pancreatic amylase and lipase activities in epileptic children treated with sodium valproate monotherapy

Cited by 11 publications

References 14 publications

Total amylase, pancreatic amylase and lipase levels in children with epilepsy on valproic acid

Total amylase, pancreatic amylase and lipase levels in children with epilepsy on valproic acid

SDS, a structural disruption score for assessment of missense variant deleteriousness

Current awareness: Pharmacoepidemiology and drug safety

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