Serum thyrotropin, thyroxine and free thyroxine concentrations as predictors of mortality in critically ill puppies with parvovirus infection: a model for human paediatric critical illness?

Schoeman, Johan P.; Herrtage, M. E.

doi:10.1016/j.micinf.2007.11.002

Cited by 35 publications

(52 citation statements)

References 22 publications

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“…Serum D‐lactate concentration was not significantly associated with outcome (survival versus death), leukocyte numbers, or the presence or absence of SIRS. Aside from potential insight into the duration of hospitalization, these findings suggest that serum D‐lactate would not serve as a useful marker when managing CPV infection or prognosticating outcomes, especially when compared to other effective measures in CPV infection such as serum thyroxine or cortisol concentrations or leukocyte changes …”

Section: Discussionmentioning

confidence: 99%

Serum D‐lactate concentrations in dogs with parvoviral enteritis

Venn

Barnes

Hansen

et al. 2020

Veterinary Internal Medicne

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Background Dogs infected with canine parvovirus (CPV) have compromised intestinal epithelial barrier integrity. Production of D‐lactate by enteric bacteria may directly reflect disease severity or contribute to metabolic acid‐base status in these dogs. Hypothesis Serum D‐lactate concentration will be increased in CPV dogs compared to healthy controls and correlate with markers of disease severity and acid‐base status. Animals Dogs with CPV undergoing treatment (n = 40) and healthy control dogs (n = 9). Methods Prospective observational study. Dogs with CPV had a baseline and daily CBC, venous blood gas with serum electrolyte concentrations, composite clinical severity score, and serum D‐lactate concentration performed. A single serum D‐lactate measurement was obtained from healthy control dogs. Results The CPV dogs had a higher D‐lactate concentration (mean ± SD) of 469 ± 173 μM compared to controls, 306 ± 45 μM (P < .001). There was no difference in baseline D‐lactate concentrations for CPV survivors (474 ± 28 μM), versus nonsurvivors (424 ± 116 μM; P = .70). D‐lactate concentration decreased over the first 4 days of treatment (−9.6 μM/d; P = .46). Dogs hospitalized for <4 days had lower baseline D‐lactate concentrations compared to those hospitalized ≥4 days (400 ± 178 μM versus 520 ± 152 μM; P = .03). No sustained correlation over time between serum D‐lactate concentration and clinical severity score or recorded acid‐base results. Conclusions and Clinical Importance Serum D‐lactate concentrations are higher in dogs with CPV compared to healthy controls but do not appear to be clinically relevant. No relationship identified between serum D‐lactate concentrations and markers of CPV disease severity, acid‐base status, or outcome.

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Section: Discussionmentioning

confidence: 99%

Serum D‐lactate concentrations in dogs with parvoviral enteritis

Venn

Barnes

Hansen

et al. 2020

Veterinary Internal Medicne

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“…Some studies performed in animal models of sepsis or septic shock support the hypothesis that relative thyroid insufficiency is associated with a worse outcome. For example, lower baseline serum T 4 and free T 4 have been associated with decreased likelihood for survival in severely ill dogs (puppies) with parvoviral diarrhea (31).…”

Section: Discussionmentioning

confidence: 99%

Association between thyroid function tests at baseline and the outcome of patients with sepsis or septic shock: a systematic review

Angelousi

Karageorgopoulos

Kapaskelis

et al. 2011

European Journal of Endocrinology

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Introduction: The severity of critical illness is associated with various patterns of thyroid hormone abnormalities. We sought to evaluate whether the outcome of patients with, specifically, sepsis or septic shock is associated with the thyroid function tests evaluated at diagnosis or admission in the intensive care unit (ICU). Methods: We performed a systematic review of relevant studies by searching PubMed. Results: We included nine studies that all had a prospective cohort design. Seven involved children or neonates, and two involved adults. Mortality was the outcome evaluated in eight studies, while the length of ICU stay was evaluated in the remaining study. In univariate analysis, six of the nine included studies showed that either, free or total, triiodothyronine or thyroxine was lower in the group of patients with sepsis or septic shock who had unfavorable outcome than in those who had favorable outcome. Two other studies showed higher TSH values in the group of patients with unfavorable outcome. No significant relevant findings were observed in the remaining study. Regarding the correlation of sepsis prognostic scoring systems with thyroid function tests, the three studies that provided specific relevant data showed variable findings. Discussion: Most of the relevant studies identified favor the concept that decreased thyroid function at baseline might be associated with a worse outcome of patients with sepsis or septic shock. Although these findings are not consistent, the role of thyroid function in affecting or merely predicting the outcome of sepsis or septic shock merits further investigation.

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“…The only clinicopathological variables associated with poor outcome in cats are leukopenia, lack of increase in leukocyte count after 3 days of hospitalization, thrombocytopenia, hypoalbuminemia, and hypokalemia . In dogs affected by parvoviral infection, serum total thyroxine (tT4) and cholesterol concentrations are significantly lower at hospital admission in nonsurvivors compared with surviving dogs . Furthermore, 2 studies evaluating the prognostic value of acute phase proteins (APPs) in dogs with parvoviral enteritis indicated that C‐reactive protein (CRP) was higher in nonsurviving dogs and positively associated with increased risk of death .…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of systemic inflammatory response syndrome and serum concentrations of acute phase proteins, cholesterol, and total thyroxine in cats with panleukopenia

Petini

Drigo

Zoia

2020

Veterinary Internal Medicne

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Background Feline parvovirus (FPV) is a common and potentially lethal infectious agent in cats. Objective To assess the prognostic value of age, neuter status, serum concentrations of serum amyloid A (SAA), haptoglobin, cholesterol and total thyroxine (tT4), and the presence of systemic inflammatory response syndrome (SIRS) in cats with panleukopenia. Animals Client‐owned cats with FPV infection diagnosed by a positive fecal ELISA test, positive PCR on feces or blood or both. Methods Retrospective cohort study. The electronic medical database was searched for cats with FPV infection presented between January 2010 and January 2018. Cats were divided into survivors and nonsurvivors according to their survival status 28 days after hospital admission. The prognostic importance of each variable was investigated univariately and by multivariable Cox's proportional‐hazards regression. Finally, receiver operator characteristic (ROC) curve analysis was used to identify the best cutoff value for discriminating survivors from nonsurvivors for the statistically significant prognostic predictors identified by multivariable analysis. Results Seventy cats were enrolled in the study. Multivariable analysis determined that only serum tT4 concentration at hospital admission was significantly (P = .01) associated with survival. A cutoff value of 0.82 μg/dL was identified by ROC curve analysis for serum tT4 concentration in discriminating survivors from nonsurvivors. Sensitivity at this cutoff was 73.9% and specificity was 82.9% (area under the curve, 0.783; 95% confidence interval, 0.668‐0.873; P < .0001). Conclusion and Clinical Relevance Serum tT4 concentration at hospital admission has prognostic value in cats with FPV infection.

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Serum thyrotropin, thyroxine and free thyroxine concentrations as predictors of mortality in critically ill puppies with parvovirus infection: a model for human paediatric critical illness?

Cited by 35 publications

References 22 publications

Serum D‐lactate concentrations in dogs with parvoviral enteritis

Serum D‐lactate concentrations in dogs with parvoviral enteritis

Association between thyroid function tests at baseline and the outcome of patients with sepsis or septic shock: a systematic review

Prognostic value of systemic inflammatory response syndrome and serum concentrations of acute phase proteins, cholesterol, and total thyroxine in cats with panleukopenia

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