Serum Thyrotrophin and Circulating Thyroglobulin and Thyroid Microsomal Antibodies in a Finnish Population

Gordin, A.; Maatela, Jouni; Miettinen, Aaro; Helenius, T; Lamberg, B.‐A.

doi:10.1530/acta.0.0900033

Cited by 66 publications

(28 citation statements)

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“…This observation was supported by reports of an association between elevated TSH and TgAb in euthyroid subjects (51,112). Population studies (22) show that not all of the TgAb and MAb positive subjects develop clinically overt thyroid disease.…”

Section: Serum Thyroglobulin and Its Autoantibodies In Healthy Personssupporting

confidence: 80%

Serum Thyroglobulin and Thyroglobulin Autoantibodies in Thyroid Diseases

Feldt‐Rasmussen

1983

Allergy

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Section: Serum Thyroglobulin and Its Autoantibodies In Healthy Personssupporting

confidence: 80%

Serum Thyroglobulin and Thyroglobulin Autoantibodies in Thyroid Diseases

Feldt‐Rasmussen

1983

Allergy

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“…The ab sence of nonthyroid autoantibodies (LE cells and adrenal antibodies) is in accordance with this assumption and confirms the con clusions of Hymans et al [30] concerning the selective appearance of autoantibodies in the elderly. Thyroid autoantibodies are known to be more prevalent in older subjects [8,16,24,27] and their presence seems correlated with that of gastric antibodies, as previously observed [2] and suggested by our data.…”

Section: Discussionsupporting

confidence: 87%

Thyroid, Lipid and Other Biological Variables in Elderly Patients with Asymptomatic Autoimmune Thyroiditis: A Statistical Analysis

1987

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Asymptomatic autoimmune thyroiditis (AAT), especially prevalent in elderly women and associated with the presence of thyroid antibodies (HT), is recognized as a precursor of hypothyroidism and is an intermediate between euthyroidism and hypothyroidism. This paper is concerned with the possible modifications of biochemical variables – some of which are not directly related to the thyroid – in patients with AAT. Thirty-seven serum factors were investigated in euthyroid, AAT, and HT subjects over 69 years of age. They were thyroglobulin; microsomal, gastric and adrenal antibodies; LE cells, and thyroid, lipid and immunological variables linked to the inflammatory process. In women the only variable, other than those related to the thyroid, which showed any modification in the AAT state was the cholesterol level. Wholly different observations were made in men, stressing the necessity of separate analysis of male and female data: the thyroid-related variables which were modified in the AAT state are not the same as in women, the cholesterol is not increased but triglycerides, HDL, albumin and inflammatory variables are modified. Furthermore, the lipid variables showed an unexpected age dependency in AAT, but not in euthyroid women (between 69–90 years of age).

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“…[2][3][4][5][6] ΑΤ is the most common cause of thyroid disorder among children and adolescents and has a wide spectrum of clinical manifestations and a variable clinical course. [6][7][8][9][10][11][12][13] Among Greek children, the prevalence of positive thyroid autoantibodies is estimated to be between 4-10%, the prevalence of goiter 3.2%, the prevalence of thyroid nodules 5.1% and the prevalence of altered thyroid echostructure approximately 9%.…”

Section: Introductionmentioning

confidence: 99%

Epidemiological characteristics of children with autoimmune thyroid disease

Skarpa¹,

Kousta²,

Tertipi³

et al. 2011

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ObsectIve: chronic autoimmune thyroiditis (At) is the most common cause of thyroid disease in children. the aim of the study was to define the epidemiological clinical and laboratory characteristics of children and adolescents with At. DesIGN: various parameters including thyroid ultrasonography of 228 children and adolescents aged 10.2±2.5yrs (mean±sD) with At, who attended our Pediatric endocrine Unit during a 5-year period were retrospectively analysed. resULts: 191 (83.8%) were female and 142 (62.3%) were pubertal. At At diagnosis, 130 children (57.0%) were euthyroid, 75 (32.9%) had subclinical hypothyroidism, 19 (8.3%) had hypothyroidism and 4 (1.8%) had hyperthyroidism. there was a positive correlation between thyroid stimulating hormone (tsH) levels and thyroid volume sDs (r=0.15, p=0.02). sixtythree children (28%) had a goiter and 32 (14%) had thyroid nodules. three children (1.3%) had papillary thyroid carcinoma. compared to euthyroid children, children with hypothyroidism were younger (9.2±1.8 vs 10.6±2.4yrs, p<0.05) and had higher thyroid volume sDs (3.1±1.9 vs 1.2±1.2, p<0.05) and higher prevalence of goiter [11(57.9%) vs 29(22.3%), p<0.05]. cONcLUsIONs: children and adolescents with At are mostly asymptomatic; the majority are female, pubertal and euthyroid. Hypothyroid children with At have higher thyroid volume, higher prevalence of goiter and higher antithyroid antibodies titers compared to euthyroid children. Diagnosing At at an early stage offers the opportunity for a timely intervention. the potential association of At with papillary thyroid carcinoma is an additional reason for a careful follow-up of the patients with At.

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Serum Thyrotrophin and Circulating Thyroglobulin and Thyroid Microsomal Antibodies in a Finnish Population

Cited by 66 publications

References 0 publications

Serum Thyroglobulin and Thyroglobulin Autoantibodies in Thyroid Diseases

Serum Thyroglobulin and Thyroglobulin Autoantibodies in Thyroid Diseases

Thyroid, Lipid and Other Biological Variables in Elderly Patients with Asymptomatic Autoimmune Thyroiditis: A Statistical Analysis

Epidemiological characteristics of children with autoimmune thyroid disease

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