Serum thyroglobulin levels predict total body iodine scan findings in patients with treated well-differentiated thyroid carcinoma

Charles, M. Arthur; Dodson, Leonard E.; Waldeck, N; Hofeldt, Fred D.; Ghaed, Nasser; Telepak, Robert J.; Ownbey, James L.; Burstein, Phil

doi:10.1016/0002-9343(80)90011-x

Cited by 63 publications

(24 citation statements)

References 17 publications

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“…The reference r nge is in accordance with the literature (8,30). However, lower normal human thyroglobulin ranges have been reported (13,17,21).…”

Section: Schlumberger and Van Herlesupporting

confidence: 89%

“…I3I I scans in connection with the measurement of serum thyroglobulin proved to be most reliable in the follow-up of those patients (7)(8)(9)(10)(11). Some authors (6,(12)(13)(14), have even proposed a reduction of scanning frequency after treatment if regul r thyroglobuiin measurements are performed. Since patients, after successful therapy of papillary and follicular thyroid carcinoma, should have no thyroglobulin in the serum (1,5, 8v9), the occurrence of metastases and recurrencies may be detected earlier by sensitive assays (5).…”

Section: Introductionmentioning

confidence: 99%

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Radioimmunoassay for Serum Thyroglobulin Designed for Early Detection of Metastases and Recurrencies in the Follow-Up of Patients with Differentiated Thyroid Carcinoma

Falk¹,

Schmidt-Gayk²,

Hüfner³

1984

Clinical Chemistry and Laboratory Medicine

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Summary:A radioimniunoassay (RIA) for the measurement of thyroglobulin in human serum was developed and factors that influence sensitivity were investigated. In a comparison of 3 different labeling procedures (chloramine T, iodogen, lactoperoxidase) iodogen-prepared tracer proved to be slightly superior with respect to sensitivity and stability. The shelf life of the tracer was improved by a protein-enriched buffer, which serves äs a radical scavenger. The binding kinetics of tracer to antibody at different temperature ranges were examined, and the most rapid and complete binding was found at room temperature. For the preparation of Standard curves, several artificial media were compared with thyroglobulin-free serum. Second antibody Separation was investigated and optimized. By employing sequential Saturation, sensitivity of 0.75 g/l (Bö-3 SD) and 50% intercept of less than 5 g/l were achieved. The results of RIA measurements of thyroglobulin in 142 patients with papillary and follicular thyroid carcinoma after thyroidectomy and 131 I treatment were compared with 131 I whole-body scans. The results confirmed that serum thyroglobulin is an early indicator of recurrency. Radioimmunoassay für Thyreoglobulin im Serum zur Früherkennung von Rezidiven und Metastasen in der

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“…The reference r nge is in accordance with the literature (8,30). However, lower normal human thyroglobulin ranges have been reported (13,17,21).…”

Section: Schlumberger and Van Herlesupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Radioimmunoassay for Serum Thyroglobulin Designed for Early Detection of Metastases and Recurrencies in the Follow-Up of Patients with Differentiated Thyroid Carcinoma

Falk¹,

Schmidt-Gayk²,

Hüfner³

1984

Clinical Chemistry and Laboratory Medicine

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“…In 1975 Van Herle and Uller proposed the concept of using Tg as a tumor marker to detect recurrent cancer in these patients (1). The hypothesis that a rise in Tg correlated with recurrent thyroid cancer was soon confirmed by others (2)(3)(4)(5)(6)(7)(8). The Tg assay has limitations in that it is not reliable in the presence of anti-Tg antibodies.…”

Section: Discussionmentioning

confidence: 96%

Effect of Postoperative¹³¹I Treatment on Thyroglobulin Measurements in the Follow-up of Patients with Thyroid Cancer

Baskin¹

1994

Thyroid

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Correlation of serum thyroglobulin (Tg) levels with recurrent cancer was performed in 200 patients who had undergone a subtotal thyroidectomy for well-differentiated thyroid carcinoma. Patients were divided into three groups: (1) those not treated postoperatively with radioactive iodine, (2) those treated with low dose (30 mCi) radioactive iodine, and (3) those treated with high dose (50-250 mCi) radioactive iodine. Tg levels proved to be reliable in detecting recurrent thyroid cancer regardless of the dose of radioactive iodine given postoperatively. These results reinforce the recommendation of using the Tg assay as the primary method of following these patients postoperatively, even when there was less than a total thyroidectomy and ablation with radioactive iodine.

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“…Ukupno, saglasni nalazi su detektovani kod 134 nalaza (82%). Sliĉno našim rezultatima, i druga istraţivanja su pokazala visoki stepen korelacije nalaza dijagnostiĉkog skena celog tela i vrednosti sTg nakon obustavljanja terapije levotiroksinom [10,11]. Vrednosti sTg u većini sluĉajeva dobro koreliraju i sa nalazima postterapijskog skena celog tela u praćenju pacijenata sa dobro diferentovanim karcinomom štitaste ţlezde [9,11].…”

Section: Wwwtmgorgrsunclassified

“…Vrednosti sTg u većini sluĉajeva dobro koreliraju i sa nalazima postterapijskog skena celog tela u praćenju pacijenata sa dobro diferentovanim karcinomom štitaste ţlezde [9,11]. Nedetektabilan Tg uglavnom prati negativan DxWBS i sugeriše kompletnu remisiju, dok detektabilan ili povišen nalaz sTg prati prisustvo pojaĉanog vezivanja radiojoda u lokalnim ili udaljenim metastazama [9][10][11][12][13].…”

Section: Wwwtmgorgrsunclassified

The role of stimulated tireoglobulin in the management of patients with differentiated thyroid carcinoma

Vlajković¹,

Rajic²,

Ilić³

et al. 2014

Tim Med Glas

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(1) CENTAR ZA NUKLEARNU MEDICINU, KLINIĈKI CENTAR NIŠ, (2) KLINIKA ZA OPŠTU HIRURGIJU, KLINIĈKI CENTAR NIŠ, (3) INSTITUT ZA ONKOLOGIJU I RADIOLOGIJU SRBIJE, KC SRBIJE, (4) CENTAR ZA NUKLEARNU MEDICINU, KLINIĈKI CENTAR KRAGUJEVAC, (5) CENTAR ZA NUKLEARNU MEDICINE, KC SRBIJE Sažetak:Cilj: Cilj ove studije je bio da ispita znaĉaj stimulisanog tireoglobulina (sTg) kod pacijenata sa diferentovanim karcinomom štitaste ţlezde nakon tireoidektomije u razliĉitim fazama praćenja tokom i nakon inicijalnog leĉenja, korelirajući nalaz sTg sa kliniĉkim nalazom, 131I-NaI dijagnostiĉkim (DxWBS) i postterapijskim skenom (TxWBS) celog tela. Ispitanici i metode: Retrospektivnom analizom je obuhvaćeno 164 DxWBS uraĊenih kod 93 pacijenta, od kojih je kod 40 uraĊen samo posthirurški sken, dok su kod ostalih uraĊeni i kontrolni skenovi. Nalaz je smatran pozitivnim ukoliko je u regionu vrata ili na drugom mestu bila vizualizovana fokalna akumulacija radiojoda, i negativnim, ukoliko je bila prisutna samo fiziološka akumulacija. Vrednosti sTg su smatrane pozitivnim ukoliko su bile iznad 2ng/ml. Rezultati: Negativna vrednost sTg je detektovana u 56 sluĉajeva negativnih DxWBS, dok je pozitivna vrednost sTg bila u skladu sa pozitivnim nalazom DxWBS u 78 sluĉajeva. Saglasni nalazi dva testa su bili prisutni u 82% sluĉajeva. Nesaglasni nalazi su detektovani u 30 sluĉajeva (18%), od kojih su kod 20 (12%) dobijeni pozitivni nalazi DxWBS i negativan nalaz sTg, a kod 10 (6%) sluĉajeva negativni nalazi DxWBS i pozitivne vrednosti sTg. Kod svih 30 pacijenata je uraĊena radiojodna ablacija/terapija. Nalaz na postterapijskom skenu je bio u skladu sa nalazom DxWBS kod 20 ispitanika sa pozitivnim DxWBS i negativnim sTg, i kod 3 ispitanika sa negativnim DxWBS i pozitivnim sTg. MeĊutim, kod 7 od 10 ispitanika sa negativnim DxWBS i pozitivnim sTg, nalaz TxWBS je ostao negativan. Zakljuĉak: Rezultati ovoga rada su pokazali da nizak nivo sTg ne moţe pojedinaĉno biti pouzdan dijagnostiĉki marker za praćenje toka bolesti kod nekih pacijenata sa diferentovanim tireoidnim karcinomom. Rezultati pokazuju da sken celog tela radiojodom uz vrednosti sTg ima izuzetno veliki znaĉaj u dijagnostiĉkom algoritmu kod pacijenata sa DTC tokom razliĉitih faza leĉenja . Ključne reči:scintigrafija celog tela, tireoglobulin, diferentovani tireoidni karcinom. Summary:Aim: The aim of this study was to evaluate the value of stimulated tireoglobulin (sTg) in patients with differentiated thyroid carcinoma (DTC) after the surgery and during the follow up period comparing the findings with the diagnostic 131I-whole body scan (DxWBS), posttherapy 131I-scan (TxWBS) and clinical findings. Patients and methods: A retrospective review comprised 164 DxWBS of 93 patiens of whom 40 patients had only postsurgical scan while in others control DxWBSs were included as well. Scan results were considered positive if any focal uptake in the neck or elsewhere was visible and negative if the physiological radioiodine accumulation persisted. Stimulated Tg is considered positive if higher than 2ng/ml. Re...

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Serum thyroglobulin levels predict total body iodine scan findings in patients with treated well-differentiated thyroid carcinoma

Cited by 63 publications

References 17 publications

Radioimmunoassay for Serum Thyroglobulin Designed for Early Detection of Metastases and Recurrencies in the Follow-Up of Patients with Differentiated Thyroid Carcinoma

Radioimmunoassay for Serum Thyroglobulin Designed for Early Detection of Metastases and Recurrencies in the Follow-Up of Patients with Differentiated Thyroid Carcinoma

Effect of Postoperative¹³¹I Treatment on Thyroglobulin Measurements in the Follow-up of Patients with Thyroid Cancer

The role of stimulated tireoglobulin in the management of patients with differentiated thyroid carcinoma

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Serum thyroglobulin levels predict total body iodine scan findings in patients with treated well-differentiated thyroid carcinoma

Cited by 63 publications

References 17 publications

Radioimmunoassay for Serum Thyroglobulin Designed for Early Detection of Metastases and Recurrencies in the Follow-Up of Patients with Differentiated Thyroid Carcinoma

Radioimmunoassay for Serum Thyroglobulin Designed for Early Detection of Metastases and Recurrencies in the Follow-Up of Patients with Differentiated Thyroid Carcinoma

Effect of Postoperative131I Treatment on Thyroglobulin Measurements in the Follow-up of Patients with Thyroid Cancer

The role of stimulated tireoglobulin in the management of patients with differentiated thyroid carcinoma

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Effect of Postoperative¹³¹I Treatment on Thyroglobulin Measurements in the Follow-up of Patients with Thyroid Cancer