Serum Thioredoxin and .ALPHA.-Tocopherol Concentrations in Patients With Major Risk Factors

Miwa, Kunihisa; Kishimoto, Chiharu; Nakamura, Hajime; Makita, Toshinori; Ishii, Katsuhisa; Okuda, Naoki; Yodoi, Junji; Sasayama, Shígetake

doi:10.1253/circj.69.291

Cited by 45 publications

(33 citation statements)

References 28 publications

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“…These findings are agreement with the previous reports that postprandial hyperglycemia is one of the risk factors for CAD through an increase in oxidative stress (6,15). Furthermore, it has been reported that hyperglycemia induces oxidative stress in an animal model and the level of thioredoxin is higher in patients with multiple coronary risk factors (16,17). The majority of patients with IGT will become DM (18,19) that in turn is associated with further increases in oxidative stress and the development of atherosclerosis (20,21).…”

Section: Discussionsupporting

confidence: 91%

Increased Plasma Levels of Thioredoxin in Patients with Glucose Intolerance

et al. 2005

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Objective The aim of the present study was to determine the effects of glucose intolerance on oxidative stress in patients with coronary artery disease (CAD).Methods The patients were divided into 3 groups, diabetes mellitus (DM), IGT or normal glucose tolerance (NGT) according to the criteria of the American Diabetes Association.Patients The present study consisted of 178 consecutive patients who underwent diagnostic coronary arteriography and a 75-g glucose tolerance test.Results The level of plasma thioredoxin, a marker of oxidative stress was measured in every patient during the fasting state. The levels of plasma thioredoxin were significantly higher in the DM and IGT groups than the NGT group. Furthermore, we found that there was a positive association between thioredoxin levels and glycosylated hemoglobin ( =0.225, p=0.018). In multivariate logistic regression analysis, glucose intolerance (DM or IGT) was only independently associated with the high levels of thioredoxin. The levels of plasma thioredoxin were significantly higher in the CAD group compared to the non-CAD group. In multivariate logistic regression analysis, high levels of thioredoxin, male, age and hypertension were independently associated with the presence of CAD.Conclusion Glucose intolerance was associated with the high levels of thioredoxin. High levels of thioredoxin were related to the presence of CAD. The measurement of thioredoxin as the marker of oxidative stress may be useful for monitoring the development of the cardiovascular diseases.

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Section: Discussionsupporting

confidence: 91%

Increased Plasma Levels of Thioredoxin in Patients with Glucose Intolerance

et al. 2005

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“…24 Recently, human thioredoxin has been quantitatively measured as a marker of oxidative stress by a sandwich enzyme-linked immunosorbent assay (ELISA). 24,25 In the present study, 33 patients, who agreed to give additional blood samples, had serum thioredoxin levels examined to verify the effect of edaravone as a free radical scavenger in patients with AMI. A sandwich ELISA method for human thioredoxin was provided by FujiRebio (Tokyo, Japan) and used as described in previous studies.…”

Section: Serial Determination Of Oxidative Stress Markersmentioning

confidence: 99%

“…A sandwich ELISA method for human thioredoxin was provided by FujiRebio (Tokyo, Japan) and used as described in previous studies. [24][25][26][27] …”

Section: Serial Determination Of Oxidative Stress Markersmentioning

confidence: 99%

Long-Term Efficacy of Edaravone in Patients With Acute Myocardial Infarction

Tsujita

Shimomura

Kaikita

et al. 2006

Circ J

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yocardial reperfusion is necessary for the salvage and recovery of the ischemic myocardium. Early reperfusion therapy has improved the clinical outcomes of patients with acute myocardial infarction (AMI), but these benefits are limited in some patients by reperfusion injuries. 1 There is now increasing evidence that reactive oxygen species (ROS) lead to reperfusion injuries in the ischemic myocardium and that they are related to subsequent left ventricular (LV) dysfunction. 2,3 Recent investigations have shown that increased vascular oxidative stress predicts the risk of cardiovascular events in patients with coronary artery disease. 4 Various different radical scavengers and antioxidants have been shown to effectively reduce reperfusion injury in experimental models. 5,6 In these ischemia-reperfusion models, it was demonstrated that radical scavengers such as superoxide dismutase and vitamin E analog reduced infarct size by limiting reperfusion-induced oxidative stress and by attenuating the inflammatory response. On the basis of this established scientific rationale, several randomized controlled trials were designed to prove or disprove the causative effects for antioxidant supplements. 7-10 Unfortunately, results of these studies on antioxidants and cardiovascular event risks have been disappointing, especially in regards to the studies investigating primary prevention. Namely, each study has several limitations to test therapeutic agents in clinical practice, mainly because of their low accessibility to tissue or rapid clearance from the body. 11,12 In contrast, edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), has a low molecular weight (174.20 kD), is lipophilic, and is readily accessible to tissue. 13,14 Edaravone has the ability to scavenge toxic free radicals; moreover, it has been shown to inhibit vascular endothelial cell injury and to inhibit the aggravation of brain edema caused by free radical-induced lipid peroxidation. 15 Recently, edaravone has been officially approved for the treatment of acute ischemic stroke in Japan. 16 Previous experimental studies have reported that the administration of edaravone just before reperfusion reduced reperfusion injuries and myocardial damage in myocardial ischemia-reperfusion animal models. 17,18 Edaravone has been shown to attenuate pressure overload-induced LV hypertrophy via its antioxidant function according to a recent report. 19 With these effects, edaravone has been recognized as both a potent cardioprotective and a cytoprotective agent. We have recently demonstrated that the administration of edaravone just prior to myocardial reperfusion attenuated both enzymatic infarct size and reperfusion arrhythmia in patients with AMI; 20 however, its effects on long-term clinical outcomes in AMI patients have not yet been clarified. The purpose of the present study was to clarify the efficacy of edaravone on the long-term prognosis in patients with AMI. Long-Term Efficacy of Edaravone in Patients With Acute Myocardial InfarctionKenichi Tsujita, MD; Hideki Shimo...

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“…17 Increases in serum TRX levels have been found in patients with various coronary risk factors, such as smoking, hypertension, and hypercholesterolemia. 18 Increases in S-glutathionylated proteins have been found in ischemic preconditioned hearts. 19 Those reports suggest that chronic oxidative stress may be involved in the progression of the coronary diseases associated with risk factors.…”

Section: Circulation Journal Vol71 January 2007mentioning

confidence: 99%

Serum Levels of S-Glutathionylated Proteins as a Risk-Marker for Arteriosclerosis Obliterans

Nonaka

Kume

Urata

et al. 2007

Circ J

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Background Oxidative stress plays a role in the development of chronic peripheral arterial disease (PAD) because under these conditions redox regulation is impaired, inducing the S-glutathionylation of proteins. A method of estimating the levels of S-glutathionylated proteins has been developed using biotinylated glutathione S-transferase, which allows the study of their crucial role in the oxidative stress-related progression of PAD. Methods and ResultsThe serum levels of S-glutathionylated proteins were examined in 41 patients with arteriosclerosis obliterans (ASO) and 38 age-matched non-ASO patients using biotinylated glutathione S-transferase. The levels were higher in the patients with ASO, even early on, and positively correlated with the ankle/brachial index. In vitro, the levels of S-glutathionylated proteins were reduced in the presence of glutathione and glutaredoxin. Conclusions Serum levels of S-glutathionylated proteins are a sensitive risk-marker for ASO at an early stage. (Circ J 2007; 71: 100 -105)

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Serum Thioredoxin and .ALPHA.-Tocopherol Concentrations in Patients With Major Risk Factors

Cited by 45 publications

References 28 publications

Increased Plasma Levels of Thioredoxin in Patients with Glucose Intolerance

Increased Plasma Levels of Thioredoxin in Patients with Glucose Intolerance

Long-Term Efficacy of Edaravone in Patients With Acute Myocardial Infarction

Serum Levels of S-Glutathionylated Proteins as a Risk-Marker for Arteriosclerosis Obliterans

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