Serum Thiol/Disulfide Homeostasis in Hemodialysis, Peritoneal Dialysis, and Renal Transplantation Patients

Budak, Yasemin; Kahvecioğlu, Serdar; Çelik, Hüseyin; Alışık, Murat; Erel, Özcan

doi:10.5262/tndt.2017.1001.17

Cited by 2 publications

(1 citation statement)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The balance between the serum levels of thiol-proteins (albumin, cysteine, cysteinyl-glycine, glutathione, homocysteine, γ-glutamyl-cysteine-albumin) and the disulfides plays a protective role in cellular redox homeostasis [ 26 , 29 ]. In the literature, abnormal thiol/disulfide homeostasis was not evaluated in cancer patients, but it was associated with urolithiasis, hemodialysis, peritoneal dialysis, renal transplantation patients, acute renal failure, chronic kidney disease, obstructive uropathy, autosomal dominant polycystic kidney disease, urinary tract infections, and malignancy [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ].…”

Section: Introductionmentioning

confidence: 99%

Posttranslational Modifications Pattern in Clear Cell Renal Cell Carcinoma

et al. 2020

View full text Add to dashboard Cite

Posttranslational modifications are dynamic enzymatic-mediated processes, regulated in time and space, associated with cancer development. We aimed to evaluate the significance of posttranslational modifications in the pathogenesis of clear cell renal cell carcinoma. The authors developed a prospective, observational study during a period of three years and included 55 patients with localized renal cell carcinoma and 30 heathy subjects. Glycosylation, nitration and carbonylation, thiol-disulfide homeostasis, methylation, phosphorylation and proteolytic cleavage were evaluated in the serum of the evaluated subjects in the present study. Our results showed some characteristics for early ccRCC: high production of cytokines, substrate hypersialylation, induced nitrosative and carbonylic stress, arginine hypermethylation, thiol/disulfide homeostasis (TDH) alteration, the regulatory role of soluble receptors (sRAGE—soluble receptor for advanced glycation end products, sIL-6R—soluble receptor for Interleukin 6) in RAGE and IL-6 signaling, the modulatory effect of TK1—thymidine kinase 1 and TuM2-PK—tumoral pyruvate-kinase 2 in controlling the level of phosphometabolites in neoplastic cells. These data could be the initial point for development of a panel of biomarkers such as total sialic acid, orosomucoids, nitrotyrosine, carbonylic metabolites, Asymmetric Dimethylarginines (ADMA), Symmetric Dimethylarginines (SDMA), and thiol-disulfide equilibrium for early diagnosis of ccRCC. Moreover, they could be considered a specific disease posttranslational modification signature which underlines the transition from early to advanced stages in this neoplasia, and of a therapeutic target in kidney oncogenesis.

show abstract

Section: Introductionmentioning

confidence: 99%

Posttranslational Modifications Pattern in Clear Cell Renal Cell Carcinoma

et al. 2020

View full text Add to dashboard Cite

show abstract

Thiol/disulphide homeostasis in Helicobacter pylori infected patients

Baykan

Bıçer

Gerçeker³

et al. 2019

The European Research Journal

Self Cite

View full text Add to dashboard Cite

Objectives:The aim of the study was to evaluate the oxidative stress level in patients, diagnosed with H. pylori infection, using a novel marker (thiol/disulphide homeostasis) and to compare the level in infected individuals with that in healthy volunteers. Methods: A total of 60 patients diagnosed with gastritis, erosive gastritis or ulcer by endoscopy were included and biopsied. The 30 patients diagnosed with H. pylori and 30 healthy individuals were enrolled. Medical histories, physical examination results, body mass index (BMI), hemogram, free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), urea, creatinin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), albumin, total cholesterol, triglycerides, high density lipoprotein (HDL), low density lipoprotein) LDL and thiol/disulphide levels obtained in the study groups were compared. Results: There was no significant difference between the total thiol, native thiol, disulphide/native thiol and dissulphide/total thiol ratios of the patient and control group. When the H. pylori patients were stratified by endoscopic evaluation as having mild (superficial gastritis or normal appearance) or severe (ulcer or erosive areas) symptoms, there were significant differences in disulphide, disulphide/native thiol, disulphide/total thiol and native thiol/total thiol levels. We also observed BMI and the total, native thiol levels of H. pylori patients were inversely related.( r: 0.562, p = 0.001; r: 0.0552, p = 0.002). Conclusions: Thiol/disulphide homeostasis is likely to differ with both duration and severity of H. pylori infection. Further investigations are needed to investigate the effect of H. pylori on oxidative stress.

show abstract

Serum Thiol/Disulfide Homeostasis in Hemodialysis, Peritoneal Dialysis, and Renal Transplantation Patients

Cited by 2 publications

References 25 publications

Posttranslational Modifications Pattern in Clear Cell Renal Cell Carcinoma

Posttranslational Modifications Pattern in Clear Cell Renal Cell Carcinoma

Thiol/disulphide homeostasis in Helicobacter pylori infected patients

Contact Info

Product

Resources

About