Serum tetranectin in patients with acute pelvic inflammatory disease (PID): Correlation to clinical and laboratory findings

Høgdall, Claus; Christiansen, Michael; Brihmer, Christina

doi:10.3109/00016349509008939

Cited by 2 publications

(2 citation statements)

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“…The value of the rst samples (collected on the day of diagnosis) of all SWP subject was used as representative of the SWP group. Consistent with the reported range (12,(17)(18)(19), the average TN concentration in healthy individuals was 11.27 + 4.39 mg/L, the median concentration, however, was 2.12 mg/L (0.81-4.41, Fig. 1A).…”

Section: Patients Characteristicssupporting

confidence: 89%

“…TN was initially identi ed as a plasminogen-binding protein in human plasma (11). A decrease in plasma TN has been observed in in ammatory diseases, such as ischemia, trauma and rheumatoid arthritis (17)(18)(19). Recently, Chen et al found that administration of endotoxin or induction of peritonitis by CLP can cause a rapid decrease in plasma TN in mice (12).…”

Section: Discussionmentioning

confidence: 99%

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Sustained Down Regulation of Plasma Tetranectin Contributes to Liver Injury in Pneumonia-Associated Sepsis

Wang

Bai

Guo

et al. 2020

Preprint

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Background: It was recently shown that tetranectin (TN) concentration in the plasma of sepsis patients was significantly lower than healthy control and that exogenous TN reduced the mortality rate in septic mice. The aim of this study is to determine whether the reduction of plasma TN is a sepsis-specific host response and its impact on organ dysfunction in sepsis.Methods: The study was conducted in the Sepsis Laboratory at the Huaihe Hospital of Henan University in China. Thirty-seven healthy, 30 community-acquired pneumonia (CAP) and 363 sepsis with comorbid pneumonia (SWP) subjects were recruited. A murine model of polymicrobial sepsis was used to characterize the role of plasma TN in sepsis pathogenesis.Results: TN concentrations in plasma from both CAP and SWP subjects were lower than healthy controls, but not significantly different between male and female sepsis patients, before and after the occurrence or the resolution of sepsis. In addition, plasma TN was not associated with the occurrence of septic shock or sepsis mortality in both genders. On the other hand, plasma TN negatively correlated with liver injury indicators in moribund SWP subjects. In mice of polymicrobial sepsis, a significant decrease in plasma TN occurred within hours after the ligation and puncture of the cecum. Recombinant human TN induced significant reductions of tissue injury markers of liver, but not other organs. In addition, exogenous TN selectively reduced the level of receptor-interacting protein kinase 3 among a panel of cell death markers in septic mouse liver. Conclusions: The dramatic and persistent down-regulation of plasma TN is not a sepsis-specific host response, but contributes to liver injury in pneumonia-associated sepsis.

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Section: Patients Characteristicssupporting

confidence: 89%