Serum testosterone, testicular connective tissue protein and testicular histology in rats treated with hyperbaric oxygen

Nakada, Teruhiro; Saito, Hidetaka; K, Ota; Saegusa, Toshio; Chikenji, Masaru; Matsushita, Taku

doi:10.1007/bf02084116

Cited by 10 publications

(2 citation statements)

References 13 publications

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“…Similarly, intermittent hypoxia in monkeys disrupted testicular architecture, reduced motility and modified se-doi: 10.17221/124/2016-VETMED men pH (Saxena 1995). In contrast, hyperoxia had no apparent effect on testicular histology in rats (Nakada et al 1986), supporting our interpretation that O 2 availability may not be the primary mechanism responsible for the observed effects. Although some studies have been conducted, there is still a relative lack of information regarding how high and low O 2 availability in vivo impact sperm.…”

Section: Discussionsupporting

confidence: 69%

Hyperthermia and not hypoxia may reduce sperm motility and morphology following testicular hyperthermia

Kastelic¹,

Wilde²,

Rizzoto³

et al. 2017

Vet. Med.

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ABSTRACT:The mammalian testis typically operates on the brink of hypoxia; the long-standing dogma is that increased testicular temperature increases metabolism, but blood flow is unaffected and the resulting hypoxia reduces sperm motility and morphology. In rats and mice, oxygen (O 2 ) content of inspired air affected O 2 content of testes, enabling the latter to range from approximately 50 to more than 200% of physiologic concentrations. A ram model was used to test the hypotheses that hypoxia would disrupt sperm motility and morphology and that hyperoxia would prevent hyperthermia-induced reductions in sperm motility and morphology. Eighteen Canadian Arcott rams (approximately 10 months old) were used in a 2 × 3 factorial, with factors being scrotal insulation (insulated or not insulated) and O 2 concentrations in inspired air (14, 21 or 85%). Six rams, three with and three without scrotal insulation, were placed in each of three enclosed areas for 30 h to expose them to their respective oxygen concentrations, with scrotal insulation removed at the end of the exposure. Semen was collected by electro-ejaculation twice before insulation, bi-weekly for four weeks starting one week after exposures, and then once weekly for two weeks. There were effects of insulation, time and an insulation × time interaction for motile sperm and sperm that had normal morphology or head or midpiece defects (P < 0.01 for each). Sperm motility and morphology exhibited alterations between approximately two and five weeks after insulation, with mean progressively motile and morphologically normal sperm decreasing from approximately 55 to 35% and from 80 to 30%, respectively, and with head and midpiece defects increasing from approximately 3 to 50% and from 10 to 20% (P < 0.05 for each). The hypotheses that hypoxia would disrupt sperm quality and production, whereas hyperoxia would prevent hyperthermia-induced reductions in sperm quality and production, were not supported. This is apparently the first report that heat-stress induced damage to sperm was due to increased temperature per se and not testicular hypoxia, calling into question a long-standing paradigm.

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Section: Discussionsupporting

confidence: 69%

Hyperthermia and not hypoxia may reduce sperm motility and morphology following testicular hyperthermia

Kastelic¹,

Wilde²,

Rizzoto³

et al. 2017

Vet. Med.

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“…The treatment of removed bladder and statistical analysis were the same as those in experiment I. A more-detailed procedure can be seen elsewhere [Nakada et al, 1976[Nakada et al, , 1986. …”

Section: Experiments I: Hbo Treatment With or Without Dox Administrationmentioning

confidence: 99%

Hyperbaric Oxygenation for Experimental Bladder Tumor

Akiya¹,

Nakada²,

Katayama³

et al. 1988

Eur Urol

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Two series of experiments were conducted to ascertain whether hyperbaric oxygenation (HBO) treatment with or without antineoplastic chemotherapy can really suppress tumor development in N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN)-induced bladder tumor in rats. HBO treatment of 2 ATA of air saturating with 30-35% of oxygen for 90 min daily plus 0.5 mg/100 g body weight of l-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)- 3-nitrosourea hydrochloride (ACNU) administration for 5 times suppressed the neoplastic spread of the bladder for 9 weeks and reduced the bladder weight in BBN-treated rats. Similar effects were also obtained in ACNU-treated rats, but to a lesser extent. HBO treatment associated with or without doxorubicin failed to suppress tumor growth in BBN-treated animals. Based on these findings combined with the previous study (part I), HBO treatment associated with ACNU might be available for the treatment of some cases of bladder tumors.

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Sex Hormones Response to Physical Hyperoxic and Hyperbaric Stress in Male Scuba Divers: A Pilot Study

Verratti

Bondi

Jandova

et al. 2019

Advances in Experimental Medicine and Biology

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Serum testosterone, testicular connective tissue protein and testicular histology in rats treated with hyperbaric oxygen

Cited by 10 publications

References 13 publications

Hyperthermia and not hypoxia may reduce sperm motility and morphology following testicular hyperthermia

Hyperthermia and not hypoxia may reduce sperm motility and morphology following testicular hyperthermia

Hyperbaric Oxygenation for Experimental Bladder Tumor

Sex Hormones Response to Physical Hyperoxic and Hyperbaric Stress in Male Scuba Divers: A Pilot Study

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