Serum testosterone mirrors inflammation parameters in females hospitalized with COVID-19

Birtolo, Maria Francesca; Vena, Walter; Pizzocaro, Alessandro; Lavezzi, Elisabetta; Brunetti, A.; Jaafar, S.; Betella, Nazarena; Bossi, Antonio; Mazziotti, Gherardo; Lania, Andrea

doi:10.1007/s40618-022-01957-6

Cited by 3 publications

(1 citation statement)

References 34 publications

(32 reference statements)

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“…Earlier research has shown that decreased testosterone levels were associated with increased CRP, PCT, and interleukin (IL)-6 levels in patients with COVID-19 ( 25 , 26 ). Furthermore, lower testosterone levels correlated with higher APACHE II and SOFA scores and independently predicted higher mortality in patients with SIC ( 27 ). Thus, declining testosterone levels could indicate worsening sepsis severity and increased mortality risk in male patients.…”

Section: Discussionmentioning

confidence: 99%

Testosterone and soluble ST2 as mortality predictive biomarkers in male patients with sepsis-induced cardiomyopathy

Wang,

Dai,

Zhu

et al. 2024

Front. Med.

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Sepsis-induced cardiomyopathy (SIC) is characterized by high mortality and poor outcomes. This study aimed to explore the relationship between testosterone and soluble ST2 (sST2) and all-cause mortality in patients with SIC. Clinical data from SIC patients at Renmin Hospital of Wuhan University from January 2021 and March 2023 were reviewed. Serum testosterone and sST2 were measured at admission. Kaplan–Meier analysis and receiver operative characteristic curve (ROC) were used to estimate the predictive values of testosterone and sST2 on 28 days and 90 days mortality of SIC. A total of 327 male subjects with SIC were enrolled in this study. During the 28 days and 90 days follow-up, 87 (26.6%) and 103 deaths (31.5%) occurred, respectively. Kaplan–Meier analysis showed significantly higher 28 days and 90 days survival in patients with higher testosterone and decreased sST2 levels (p < 0.001). Testosterone, sST2, and N-terminal pro-B-type natriuretic peptide (NT-proBNP) were significantly associated with 28 days and 90 days mortality (p < 0.05). Partial correlation analysis showed strong positive correlation between testosterone and left ventricular ejection fraction (LVEF) (p < 0.001), and negative correlation between testosterone and sST2 (p < 0.001), high-sensitivity troponin I (hs-TnI) levels (p < 0.001) and smoke history (p < 0.01). The concentrations of sST2 were positively related with E/e′ ratio (p < 0.001), and negatively correlated with TAPSE (p < 0.001). The combination of testosterone and sST2 enhanced the prediction of both 28 days [area under the ROC curve (AUC), 0.805] and 90 days mortality (AUC, 0.833). Early serum testosterone and sST2 levels could predict mortality of SIC independently and jointly. Further research is needed to determine the utility of biochemical markers in identifying high-risk patients with SIC.

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Section: Discussionmentioning

confidence: 99%

Testosterone and soluble ST2 as mortality predictive biomarkers in male patients with sepsis-induced cardiomyopathy

Wang,

Dai,

Zhu

et al. 2024

Front. Med.

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Heterogeneity in regional changes in body composition induced by androgen deprivation therapy in prostate cancer patients: potential impact on bone health—the BLADE study

Volta

Palumbo

Zamboni

et al. 2023

J Endocrinol Invest

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Background It is not clear whether changes in body composition induced by androgen deprivation therapy (ADT) in prostate cancer (PC) patients are uniform or vary in the different body districts and whether regional lean body mass (LBM) and fat body mass (FBM) could have an impact on bone health. Objective To prospectively evaluate the regional changes in LBM and FBM in PC patients submitted to degarelix; to explore the relationship of regional body composition and bone mineral density (BMD) and bone turnover markers. Design, setting, and participants 29 consecutive non metastatic PC patients enrolled from 2017 to 2019. FBM, LBM and bone mineral density (BMD) evaluated by dual-energy x-ray absorptiometry (DXA) at baseline and after 12-month of ADT. Alkaline phosphate (ALP) and C-terminal telopeptide of type I collagen (CTX) assessed at baseline, 6 and 12 months. Intervention All patients underwent degarelix administration. Outcome measurements and statistical analysis T-test or sign test and Pearson or Spearman test for continuous variables were used when indicated. Results and limitations Median percent increase in FBM ranged from + 14.5% in trunk to + 25.4% in the left leg after degarelix. LBM changes varied from + 2% in the trunk to − 4.9% in the right arm. LBM in both arms and legs and their variations after degarelix directly correlated with ALP and inversely correlated with CTX. Lean mass of limbs, trunk and legs significantly correlated with BMD of the hip, lean mass of the trunk significantly correlated with spine BMD. These are post-hoc analysis of a prospective study and this is the main limitation. Conclusions an heterogeneous change in body composition among body district is observed after ADT and bone turnover is influenced by lean mass and its variation. A supervised physical activity is crucial to maintain general physical performance and preserving bone health.

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The impact of menopause and serum DHEA-S level on the severity of Covid-19

Erel,

Ozcivit Erkan,

Inan

et al. 2024

Maturitas

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Serum testosterone mirrors inflammation parameters in females hospitalized with COVID-19

Cited by 3 publications

References 34 publications

Testosterone and soluble ST2 as mortality predictive biomarkers in male patients with sepsis-induced cardiomyopathy

Testosterone and soluble ST2 as mortality predictive biomarkers in male patients with sepsis-induced cardiomyopathy

Heterogeneity in regional changes in body composition induced by androgen deprivation therapy in prostate cancer patients: potential impact on bone health—the BLADE study

The impact of menopause and serum DHEA-S level on the severity of Covid-19

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