Serum testosterone levels of HbSS (sickle cell disease) male subjects in Lagos, Nigeria

Abudu, Emmanuel Kunle; Soriyan, Oyetunji O; Akinbami, Akinsegun; Adediran, Adewumi; Adeyemo, Titilope A.

doi:10.1186/1756-0500-4-298

Cited by 14 publications

(11 citation statements)

References 14 publications

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“…Several clinical studies have demonstrated decreased serum testosterone levels in male patients with SCD [ 6 – 12 ], with rates of testosterone deficiency as high as 25% [ 13 ]. Testosterone deficiency in SCD is associated with retardation of physical development [ 12 ], infertility [ 14 ], bone mass loss [ 7 ], and possibly priapism [ 13 ]. The mechanism underlying testosterone deficiency in SCD is not clear, as both increased and decreased luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels have been measured in SCD patients.…”

Section: Introductionmentioning

confidence: 99%

Mechanism of Testosterone Deficiency in the Transgenic Sickle Cell Mouse

Musicki¹,

Zhang²,

Chen

et al. 2015

PLoS ONE

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Testosterone deficiency is associated with sickle cell disease (SCD), but its underlying mechanism is not known. We investigated the possible occurrence and mechanism of testosterone deficiency in a mouse model of human SCD. Transgenic sickle male mice (Sickle) exhibited decreased serum and intratesticular testosterone and increased luteinizing hormone (LH) levels compared with wild type (WT) mice, indicating primary hypogonadism in Sickle mice. LH-, dbcAMP-, and pregnenolone- (but not 22-hydroxycholesterol)- stimulated testosterone production by Leydig cells isolated from the Sickle mouse testis was decreased compared to that of WT mice, implying defective Leydig cell steroidogenesis. There also was reduced protein expression of steroidogenic acute regulatory protein (STAR), but not cholesterol side-chain cleavage enzyme (P450scc), in the Sickle mouse testis. These data suggest that the capacity of P450scc to support testosterone production may be limited by the supply of cholesterol to the mitochondria in Sickle mice. The sickle mouse testis exhibited upregulated NADPH oxidase subunit gp91phox and increased oxidative stress, measured as 4-hydroxy-2-nonenal, and unchanged protein expression of an antioxidant glutathione peroxidase-1. Mice heterozygous for the human sickle globin (Hemi) exhibited intermediate hypogonadal changes between those of WT and Sickle mice. These results demonstrate that testosterone deficiency occurs in Sickle mice, mimicking the human condition. The defects in the Leydig cell steroidogenic pathway in Sickle mice, mainly due to reduced availability of cholesterol for testosterone production, may be related to NADPH oxidase-derived oxidative stress. Our findings suggest that targeting testicular oxidative stress or steroidogenesis mechanisms in SCD offers a potential treatment for improving phenotypic changes associated with testosterone deficiency in this disease.

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Section: Introductionmentioning

confidence: 99%

Mechanism of Testosterone Deficiency in the Transgenic Sickle Cell Mouse

Musicki¹,

Zhang²,

Chen

et al. 2015

PLoS ONE

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“…Infertility is a major problem in male sickle cell disease patients reported by Abudu et al in which they noted a lower testosterone levels in males compared with age-matched controls [16]. Impotence has also been reported in about a quarter of sickle cell disease patients secondary to priapism [6].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Priapism and Its Awareness amongst Male Homozygous Sickle Cell Patients in Lagos, Nigeria

Adediran

Wright

Akinbami

et al. 2013

Advances in Urology

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Background. Priapism is a pathological condition of penile erection that persists beyond, or is unrelated to, sexual stimulation. Impotence and infertility are major problems in male sickle cell disease patients, and priapism has been implicated as a cause of impotence and infertility. The aim of this study is to determine priapism prevalence and assess the knowledge of male homozygous male patients about it in Lagos, Nigeria. Methods. A cross-sectional study was conducted amongst male homozygous sickle cell disease patients of Lagos State University Teaching Hospital. Pretested questionnaires were distributed to determine the prevalence and assess their knowledge on priapism. Data were analyzed using SPSS version 16.0. Results. A total of 114 consenting subjects filled the questionnaires, 85 of 114 (74.6%) had not heard about priapism before this study. A total of 77 of 114 (67.5%) did not know that they are at risk of priapism. Whilst 84 of 114 (73.7%) were not aware that priapism is a complication of SCD. The majority, 94 of 114 (82.5%), were not aware that priapism could cause impotence. Conclusion. There is a need to create more awareness about this complication amongst sickle cell disease patients in order to stem the incidence of impotence and infertility amongst them.

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“…In addition to low serum T, other abnormalities involving the accessory sex organs, such as the seminal vesicles and the prostate gland, as well as marked decrease in ejaculate volume and sperm parameters may be observed in male patients. [ 3 4 5 6 7 8 9 10 11 12 13 14 15 26 ] Recently, some data showed that blood transfusion produce significant acute changes in the hormonal milieu and sperm parameters of patients with chronic hemolytic anemia. [ 27 28 29 ] Therefore, we studied the acute effects of PCTx on spontaneous spermatogenesis and pituitary testicular axis in young eugonadal males with transfusion-requiring SCD (10 were on TTx and eight were on ETx).…”

Section: Discussionmentioning

confidence: 99%

Does blood transfusion affect pituitary gonadal axis and sperm parameters in young males with sickle cell disease?

Soliman

Yasin

Elawwa

et al. 2013

Indian J Endocr Metab

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Objective:We evaluated the effect of packed red cell transfusion (PCTx) on serum concentrations of gonadotropins luteinizing hormone and follicle-stimulating hormone (LH and FSH) and testosterone (T) levels and measured sperm parameters in young adults with sickle cell disease (SCD) on top-up transfusion (TTx) and those on exchange transfusion (ETx) regimen.Materials and Methods:Basal serum concentrations of FSH, LH, and T and semen parameters were evaluated before and 7 days after PCTx in 18 young adults with transfusion-dependent SCD, aged 20.7 ± 2.88 years. They had full pubertal development (Tanner's stage 5), and capacity to ejaculate. They were regularly transfused since early childhood. Chelation therapy was started early during the first 2 years of life using desferrioxamine and was replaced by deferasirox for the last 4-5 years. Ten patients were on TTx and eight were on ETx regimen.Results:PCTx significantly increased hemoglobin (Hb) from 8.5 ± 1.17 g/dl to 10.5 ± 0.4 g/dl, T from 12.3 ± 1.24 nmol/L to 14.23 ± 1.22 nmol/L and gonadotropins’ concentrations. Sperm parameters improved significantly after PCTx including: total sperm count from 87.4 ± 24.6 million/ml to 146.2 ± 51.25 million/ml, total progressive sperm motility (TPM) from 40.8 ± 11.1 million/ml to 93.4 ± 38.3 million/ml, rapid progressive sperm motility (RPM) progressive motility from 29.26 ± 8.75 million/ml to 67.4 ± 29 million/ml. After PCTx the total sperm count, TPM and RPM were significantly better in the ETx group versus the TTx group. Before and after PCTx, T concentrations were correlated significantly with sperm total count, volume, TPM and RPM (r = 0.53, 0.55, 0.42, and 0.38, respectively, P < 0.01). Hb concentrations were correlated significantly with sperm count, TPM, RPM, and % of sperms with normal morphology (r = 0.60, 0.69, 0.66, and 0.86, respectively, P < 0.001).Conclusion:Our study suggests that in males with SCD blood transfusion is associated with significant acute enhancement of sperm parameters and with increased concentrations of serum T, LH, and FSH. Improvement of sperm parameters were significantly better in the ETx group verses the TTx group. These “acute” effects on spermiogenesis are reached with an unknown mechanism/s and suggest a number of pathways that need further human and/or experimental studies.

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Serum testosterone levels of HbSS (sickle cell disease) male subjects in Lagos, Nigeria

Cited by 14 publications

References 14 publications

Mechanism of Testosterone Deficiency in the Transgenic Sickle Cell Mouse

Mechanism of Testosterone Deficiency in the Transgenic Sickle Cell Mouse

Prevalence of Priapism and Its Awareness amongst Male Homozygous Sickle Cell Patients in Lagos, Nigeria

Does blood transfusion affect pituitary gonadal axis and sperm parameters in young males with sickle cell disease?

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