Serum testosterone levels in type 2 diabetes mellitus

Abstract

Introduction: Diabetes mellitus is a multifactorial disease which is characterised by hyperglycaemia, dyslipidaemia, involves various organ systems, and results in various long-term complications. Several studies have suggested that men with low testosterone levels are at a greater risk of developing type 2 diabetes mellitus, and that low testosterone levels may even predict the onset of diabetes. Recent studies have shown that a low serum testosterone level is strongly associated with an increased likelihood of the metabolic syndrome. Aim: To compare the serum total testosterone levels in type 2 diabetes mellitus patients with that of non-diabetic healthy controls. Material and Methods: The study was conducted in OPD of Medical College, Kolkata. In the present study 50 men aged 35-55 years who were diagnosed as type 2 diabetes mellitus patients and confirmed by the estimation of fasting plasma glucose (≥126mg/dl), post prandial blood glucose (≥200mg/dl) and HbA 1C (≥6.5%) were selected, 50 healthy age and BMI matched individuals, were selected as controls. Patients with a known history of hypogonadism, panhypopituitarism, hyperthyroidism, patients taking exogenous testosterone and glucocorticoids, patients suffering from chronic debilitating disease, such as renal failure, cardiac failure, liver cirrhosis, or HIV, were excluded from the study. The laboratory investigations included evaluation of serum testosterone levels, fasting and postprandial blood glucose, with the levels of HbA 1c and Creatinine. Statistical analysis was performed using SPSS 20.0. Results are represented as mean±SD and number (%). Pearson's correlation test was performed to measure the linear dependence of the study parameters. Results: Serum Total Testosterone level of diabetic group was 3.51±1.26ng/ml, which was found significantly lower than control group with serum total testosterone level 5.88±2.34ng/ml, (p-value < 0.0001). Conclusion: This study has shown that there is a significant reduction in serum total testosterone levels in type 2 diabetes mellitus patients.

Testosterone Correlation with Low and High Density Lipoprotein in Male Type 2 Diabetics

“…Serum testosterone in cases was 10.85 ± 4.7 mmol/L compared to 13.39 ± 3.8 mmol/L (P=0.0001), the difference being highly significant between cases and controls. This is in agreement with previous studies [7,13]. A pervious study shows the values of 3.51±1.26 ng/ml in male type 2 diabetic cases compared to 5.88±2.34 ng/ml in non-diabetic male that is agreement with our present study [7].…”

“…This is in agreement with previous studies [7,13]. A pervious study shows the values of 3.51±1.26 ng/ml in male type 2 diabetic cases compared to 5.88±2.34 ng/ml in non-diabetic male that is agreement with our present study [7]. A previous study reported twice low testosterone in male type 2 diabetics in comparison to non -diabetic control male [14].…”

“…Similar finding of negative linear correlation of testosterone with cholesterol, TAGs, HDLc and positive correlation with LDLc was reported by a previous study [11]. Of 100 male types 2 diabetics, 46% cases exhibited low testosterone in present study the finding is agreed by previous studies [7,[11][12]. Previous studies found low testosterone in 44.5% and 42% respectively [11][12].…”

“…ELISA assay method utilized for determining the serum testosterone. Testosterone lower range was taken as [7]. Pearson`s correlation was analyzed on Statistical software SPSS 21.0 (IBM, Incorp, USA) for determining the association/correlation of serum testosterone with blood lipids.…”