Serum Telomerase Levels and COPD Exacerbations

Bozkuş, Fulsen; Güler, Selma; Sımsek, Secıl

doi:10.4187/respcare.04389

Cited by 11 publications

(4 citation statements)

References 38 publications

(40 reference statements)

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“…COPD. In conclusion, the findings of our previous study suggest that an impaired balance between oxidants and antioxidants in favour of oxidants is associated with increased levels of telomerase [29] .…”

Section: Research Highlightsupporting

confidence: 52%

Could Serum Levels of Telomerase be Considered as an Oxidative Stress Marker in COPD?

Bozkuş

2016

Telomere Telomerase

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Telomeres are specialized regions of repetitive sequences that found at each end of chromosomes and have an important function in protecting the genomic integrity. In the absence of telomerase functioning in the proliferating cells, every mitotic division progressively shorten telomeres which ultimately leads to senescence of the cells. Therefore, shortening of telomeres' length is recognized as a mechanism having important functional implications and believed to reflect cellular ageing. However, shortening of telomeres is not the only factor which determines destiny of the cells. Another critical factor affecting this fate is the presence of telomerase which is a polymerase ezyme buffering telomere shortening. Telomere biology has been implicated not only in the cell ageing process, but also in multiple aging-associated conditions and diseases.The critical roles of temomeres and telomerase in cellular ageing and possibly in disease have been demonstrated in recent studies. The experimental findings indicate oxidative stress as a key determinant for telomere shortening which may lead to the hypothesis of telomerase levels may be evaluated as a response to oxidative stress. Oxidative stress is recognized as one of the primary pathogenetic mechanisms involved in COPD, and in particular COPD exacerbation. Our recent finding indicates that the serum levels of telomerase were increased in COPD patients during the attack period. To cite this article: Fulsen Bozkus. Could serum levels of telomerase be considered as an oxidative stress marker in COPD?

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Section: Research Highlightsupporting

confidence: 52%

Could Serum Levels of Telomerase be Considered as an Oxidative Stress Marker in COPD?

Bozkuş

2016

Telomere Telomerase

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“…Although neither antioxidant-related enzymes nor antioxidative capacity was quantified in this study, serum telomerase level was investigated as an oxidative stress marker 27 , 28 . The effect of D-gal plus HFD-induced aging and obesity on accelerated systemic oxidative stress was detected early, at week 4, through an increase in serum telomerase level.…”

Section: Discussionmentioning

confidence: 99%

D-galactose-induced aging aggravates obesity-induced bone dyshomeostasis

Imerb

Thonusin

Pratchayasakul

et al. 2022

Sci Rep

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We aimed to compare the time-course effect of D-galactose (D-gal)-induced aging, obesity, and their combined effects on bone homeostasis. Male Wistar rats were fed with either a normal diet (ND; n = 24) or a high-fat diet (HFD; n = 24) for 12 weeks. All rats were then injected with either vehicle or 150 mg/kg/day of D-gal for 4 or 8 weeks. Blood was collected to measure metabolic, aging, oxidative stress, and bone turnover parameters. Bone oxidative stress and inflammatory markers, as well as bone histomorphometry were also evaluated. Additionally, RAW 264.7 cells were incubated with either D-gal, insulin, or D-gal plus insulin to identify osteoclast differentiation capacity under the stimulation of receptor activator of nuclear factor κB ligand. At week 4, D-gal-induced aging significantly elevated serum malondialdehyde level and decreased trabecular thickness in ND- and HFD-fed rats, when compared to the control group. At week 8, D-gal-induced aging further elevated advanced glycation end products, increased bone inflammation and resorption, and significantly impaired bone microarchitecture in HFD-fed rats. The osteoclast number in vitro were increased in the D-gal, insulin, and combined groups to a similar extent. These findings suggest that aging aggravates bone dyshomeostasis in the obese condition in a time-dependent manner.

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“…Nonetheless, telomerase helps to prevent telomere shortening. In this regard, individuals with chronic obstructive pulmonary disease (COPD) show higher levels of telomerase compared to smokers' levels [54]. In addition, it is known that telomerase levels are higher in children that suffered burns and even higher in individuals with an amputated extremity [55].…”

Section: Discussionmentioning

confidence: 99%

Effect of Sechium edule var. nigrum spinosum (Chayote) on Telomerase Levels and Antioxidant Capacity in Older Adults with Metabolic Syndrome

et al. 2020

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Patients with metabolic syndrome (MetS) have a redox imbalance, due to a decay in antioxidant capacity. Oxidative stress (OxS) is considered an important modulator of telomere shortening and telomerase activity. One of the fruits that has been associated with an antioxidant effect is Sechium edule and although its properties are well established, there is only one exploratory study evaluating its effectiveness in patients with MetS. The present investigation is a much more robust and controlled study, including a placebo group. Hence, we determined the effect of consumption of the dried fruit powder (500 mg, three times per day) for three months. We measured effects on telomerase levels, antioxidant capacity, and markers for OxS. The study was performed in a sample of 75 older adults: placebo group (n = 30) and experimental group (n = 45) with the diagnosis of MetS according to the National Adult Treatment Panel of the National Cholesterol Program III (NCEP/ATP III) criteria. All markers were measured before and after three months of treatment. There was a statistically significant decrease in lipoperoxides and protein carbonylation with an increased superoxide dismutase (SOD), as well as sustained levels of telomerase in patients who consumed Sechium edule. Our findings suggest that consumption of this fruit has a hypoglycemic, hypotensive, and antioxidant effect, without altering telomerase levels, which could suggest better protection against telomere shortening.

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Serum Telomerase Levels and COPD Exacerbations

Cited by 11 publications

References 38 publications

Could Serum Levels of Telomerase be Considered as an Oxidative Stress Marker in COPD?

Could Serum Levels of Telomerase be Considered as an Oxidative Stress Marker in COPD?

D-galactose-induced aging aggravates obesity-induced bone dyshomeostasis

Effect of Sechium edule var. nigrum spinosum (Chayote) on Telomerase Levels and Antioxidant Capacity in Older Adults with Metabolic Syndrome

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