Serum Talin-1 is a Potential Novel Biomarker for Diagnosis of Hepatocellular Carcinoma in Egyptian Patients

Youns, Mаhmoud; Wahab, Abdel; Hassan, Zeinab; Attia, Mohamed S.

doi:10.7314/apjcp.2013.14.6.3819

Cited by 29 publications

(25 citation statements)

References 25 publications

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“…Parallel combination of AFP and taline-1 raise the sensitivity and specificity up to 100% and 84% , respectively. Our results were in agreement with Youns et al, [15] who studied the diagnostic utility of talin-l in diagnosis of HCC, they found that at acutoff value of 33.7 ng/ml the diagnostic sensitivity was 100% and specificity 87%. ROC curve analysis showed AUC for taline-1 was higher than that of AFP alone or in combination with taline.…”

Section: Discussionsupporting

confidence: 93%

“…Also, there was a high significant increase in cirrhotic patients compared with the controls. These results are similar to that of Youns et al, [15] who found that serum talin-1 levels were significantly higher in the HCC group than in the liver cirrhosis group and controls. Moreover, (14)Kanamori et al,reported that talin-1 expression levels in HCC nodules identified by differential tissue proteome were significantly associated with undifferentiated HCC and showed correlation between talin-1 upregulation and a shorter time to recurrence after resection.…”

Section: Discussionsupporting

confidence: 91%

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Evaluation of Taline-1, MCP-1 and IGF-1 in Prediction the Risk of Developing Hepatocellular Carcinoma in Patients With Liver Cirrhosis

Khodeer¹,

Allah²,

Alwakeel³

et al. 2017

IOSR JBB

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Evaluation of Taline-1, MCP-1 and IGF-1 in Prediction the Risk of Developing Hepatocellular Carcinoma in Patients With Liver Cirrhosis

Khodeer¹,

Allah²,

Alwakeel³

et al. 2017

IOSR JBB

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“…Egyptian investigators have reported that Serum levels of TLN1 in hepatocellular carcinoma patients were significantly higher compared to the liver cirrhosis (LC) and healthy controls. (Youns MM., et al 2013). The overexpression of Talin-1 has been reported to enhance prostate cancer cell adhesion, migration, and invasion by activating survival signals and conferring resistance to anoikis (Sakamoto et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Talin-1 Correlates with Reduced Invasion and Migration in Human Hepatocellular Carcinoma Cells

Fang

Zhang²,

Ren³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…However, among various populations, Talin-1 expression in HCC is still controversial. Khodeer et al (2017) and Youns et al (2013) [15,40] found significantly higher levels of serum Talin-1 in HCC Egyptian patients in comparison to both cirrhotic and control groups. On the other hand, another study within the same population indicated significantly lower levels of serum Talin-1 in HCC patients than patients with cirrhosis and normal subjects [41].…”

Section: Discussionmentioning

confidence: 95%

Talin-1 Gene Expression as a Tumor Marker in Hepatocellular Carcinoma Patients: A Pilot Study

Mohamed¹,

El-Toukhy²,

Ghaith³

et al. 2020

TOBIOMJ

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Background & Aims: Hepatocellular Carcinoma (HCC) is the most common primary liver tumor. It is the second most common cancer in men and the sixth in women in Egypt. One of the proteins participating in the trans-endothelial migration is Talin-1. It also has a role in the formation and metastasis of different types of cancer. This study aimed to evaluate the diagnostic impact of Talin-1 gene expression in HCC Egyptian patients. Methods: Our study included forty HCC patients, thirty liver cirrhosis patients without HCC and thirty healthy subjects. For all groups, clinical and biochemical parameters were investigated. Tumor characteristics were assessed and tumor staging was done using Okuda, CLIP, VISUM and Tokyo staging systems. In addition, Serum Alpha-Fetoprotein (AFP) levels were assayed using Enzyme Immunoassay (EIA) and Talin-1 gene expression was assessed in the Peripheral Blood Mononuclear Cells (PBMCs) via quantitative real-time Polymerase Chain Reaction (PCR). Results: Talin-1 gene expression was significantly upregulated in HCC patients in comparison to cirrhotic and control subjects. The Receiver Operating Characteristic (ROC) analysis indicated that Talin-1 gene expression surpasses serum levels of AFP in the diagnosis of HCC. In particular, the cut off value of 9.5 (2-∆∆Ct) recorded an AUC of 85.7% with a sensitivity of 93.3% and specificity of 80%. Conclusion: Our data confirmed an évident diagnostic role of Talin-1 gene expression for HCC detection.

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Serum Talin-1 is a Potential Novel Biomarker for Diagnosis of Hepatocellular Carcinoma in Egyptian Patients

Cited by 29 publications

References 25 publications

Evaluation of Taline-1, MCP-1 and IGF-1 in Prediction the Risk of Developing Hepatocellular Carcinoma in Patients With Liver Cirrhosis

Evaluation of Taline-1, MCP-1 and IGF-1 in Prediction the Risk of Developing Hepatocellular Carcinoma in Patients With Liver Cirrhosis

Talin-1 Correlates with Reduced Invasion and Migration in Human Hepatocellular Carcinoma Cells

Talin-1 Gene Expression as a Tumor Marker in Hepatocellular Carcinoma Patients: A Pilot Study

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