Serum Surfactant Protein D is Associated with Atherosclerosis of the Carotid Artery in Patients on Maintenance Hemodialysis

Hu, Fengqi; Zhong, Qinglian; Gong, Jianhua; Qin, Yongfang; Cui, Long; Yuan, Hai

doi:10.7754/clin.lab.2015.150536

Cited by 10 publications

(7 citation statements)

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“…SP-D was also associated with all-cause mortality in the ECLIPSE COPD cohort ( 287 ), as described above, and in a study of the relationships among COPD, coronary artery calcification, and mortality using the same cohort, circulatory SP-D was correlated with Agatston score ( 432 ). The relationship between SP-D and CVD is further supported by the observation of Hu et al ( 452 ) of positive associations between circulatory SP-D levels and carotid artery intima-media thickness and severe coronary artery calcification, which persisted after multivariate adjustment. Hill et al ( 429 ) and Hu et al ( 452 ) did not report BAL SP-D or other means of monitoring the presence of lung disease and, therefore, did not address the question of the organ source of circulatory SP-D.…”

Section: Sp-d In Non-respiratory Diseasesmentioning

confidence: 55%

“…The relationship between SP-D and CVD is further supported by the observation of Hu et al ( 452 ) of positive associations between circulatory SP-D levels and carotid artery intima-media thickness and severe coronary artery calcification, which persisted after multivariate adjustment. Hill et al ( 429 ) and Hu et al ( 452 ) did not report BAL SP-D or other means of monitoring the presence of lung disease and, therefore, did not address the question of the organ source of circulatory SP-D.…”

Section: Sp-d In Non-respiratory Diseasesmentioning

confidence: 55%

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Surfactant Protein D in Respiratory and Non-Respiratory Diseases

2018

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Surfactant protein D (SP-D) is a multimeric collectin that is involved in innate immune defense and expressed in pulmonary, as well as non-pulmonary, epithelia. SP-D exerts antimicrobial effects and dampens inflammation through direct microbial interactions and modulation of host cell responses via a series of cellular receptors. However, low protein concentrations, genetic variation, biochemical modification, and proteolytic breakdown can induce decomposition of multimeric SP-D into low-molecular weight forms, which may induce pro-inflammatory SP-D signaling. Multimeric SP-D can decompose into trimeric SP-D, and this process, and total SP-D levels, are partly determined by variation within the SP-D gene, SFTPD. SP-D has been implicated in the development of respiratory diseases including respiratory distress syndrome, bronchopulmonary dysplasia, allergic asthma, and chronic obstructive pulmonary disease. Disease-induced breakdown or modifications of SP-D facilitate its systemic leakage from the lung, and circulatory SP-D is a promising biomarker for lung injury. Moreover, studies in preclinical animal models have demonstrated that local pulmonary treatment with recombinant SP-D is beneficial in these diseases. In recent years, SP-D has been shown to exert antimicrobial and anti-inflammatory effects in various non-pulmonary organs and to have effects on lipid metabolism and pro-inflammatory effects in vessel walls, which enhance the risk of atherosclerosis. A common SFTPD polymorphism is associated with atherosclerosis and diabetes, and SP-D has been associated with metabolic disorders because of its effects in the endothelium and adipocytes and its obesity-dampening properties. This review summarizes and discusses the reported genetic associations of SP-D with disease and the clinical utility of circulating SP-D for respiratory disease prognosis. Moreover, basic research on the mechanistic links between SP-D and respiratory, cardiovascular, and metabolic diseases is summarized. Perspectives on the development of SP-D therapy are addressed.

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Section: Sp-d In Non-respiratory Diseasesmentioning

confidence: 55%

Section: Sp-d In Non-respiratory Diseasesmentioning

confidence: 55%

Surfactant Protein D in Respiratory and Non-Respiratory Diseases

2018

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“…The study found that increased serum SP-D was associated with total mortality in patients with documented coronary artery disease also when adjusting for well-established risk factors such as smoking, age, sex, plasma cholesterol, and plasma IL-6 levels. The relationship between SP-D and CVD was further supported by Hu et al (51), showing a positive association between circulatory SP-D level and carotid intima-media thickness and coronary artery calcification.…”

Section: Sp-d Variation In Clinical Studiesmentioning

confidence: 56%

The Dual Role of Surfactant Protein-D in Vascular Inflammation and Development of Cardiovascular Disease

2019

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Cardiovascular disease (CVD) is responsible for 31% of all global deaths. Atherosclerosis is the major cause of cardiovascular disease and is a chronic inflammatory disorder in the arteries. Atherosclerosis is characterized by the accumulation of cholesterol, extracellular matrix, and immune cells in the vascular wall. Recently, the collectin surfactant protein-D (SP-D), an important regulator of the pulmonary immune response, was found to be expressed in the vasculature. Several in vitro studies have examined the role of SP-D in the vascular inflammation leading to atherosclerosis. These studies show that SP-D plays a dual role in the development of atherosclerosis. In general, SP-D shows anti-inflammatory properties, and dampens local inflammation in the vessel, as well as systemic inflammation. However, SP-D can also exert a pro-inflammatory role, as it stimulates C-C chemokine receptor 2 inflammatory blood monocytes to secrete tumor necrosis-factor α and increases secretion of interferon-γ from natural killer cells. In vivo studies examining the role of SP-D in the development of atherosclerosis agree that SP-D plays a proatherogenic role, with SP-D knockout mice having smaller atherosclerotic plaque areas, which might be caused by a decreased systemic inflammation. Clinical studies examining the association between SP-D and cardiovascular disease have reported a positive association between circulatory SP-D level, carotid intima-media thickness, and coronary artery calcification. Other studies have found that circulatory SP-D is correlated with increased risk of both total and cardiovascular disease mortality. Both in vitro, in vivo, and clinical studies examining the relationship between SP-D and CVDs will be discussed in this review.

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“…SFTPD was reported exacerbating the development of atherosclerosis in previous literatures [ 21 , 46 – 48 ]. In recent decades, bacterial infections and chronic inflammation have become possible causes of cardiovascular disease.…”

Section: Discussionmentioning

confidence: 98%

Transcriptome-wide association study identified candidate genes associated with gut microbiota

et al. 2021

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Background Gut microbiota is closely associated with host health and disease occurrence. Host genetic factor plays an important role in shaping gut microbial communities. The specific mechanism of host-regulated gene expression affecting gut microbiota has not been elucidated yet. Here we conducted a transcriptome-wide association study (TWAS) for gut microbiota by leveraging expression imputation from large-scale GWAS data sets. Results TWAS detected multiple tissue-specific candidate genes for gut microbiota, such as FUT2 for genus Bifidobacterium in transverse colon (PPERM.ANL = 1.68 × 10–3) and SFTPD for an unclassified genus of Proteobacteria in transverse colon (PPERM.ANL = 5.69 × 10–3). Fine mapping replicated 3 candidate genes in TWAS, such as HELLS for Streptococcus (PIP = 0.685) in sigmoid colon, ANO7 for Erysipelotrichaceae (PIP = 0.449) in sigmoid colon. Functional analyses detected 94 significant GO terms and 11 pathways for various taxa in total, such as GO_NUCLEOSIDE_DIPHOSPHATASE_ACTIVITY for Butyrivibrio (FDR P = 1.30 × 10–4), KEGG_RENIN_ANGIOTENSIN_SYSTEM for Anaerostipes (FDR P = 3.16 × 10–2). Literature search results showed 12 genes prioritized by TWAS were associated with 12 diseases. For instance, SFTPD for an unclassified genus of Proteobacteria was related to atherosclerosis, and FUT2 for Bifidobacterium was associated with Crohn’s disease. Conclusions Our study results provided novel insights for understanding the genetic mechanism of gut microbiota, and attempted to provide clues for revealing the influence of genetic factors on gut microbiota for the occurrence and development of diseases.

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Serum Surfactant Protein D is Associated with Atherosclerosis of the Carotid Artery in Patients on Maintenance Hemodialysis

Cited by 10 publications

References 0 publications

Surfactant Protein D in Respiratory and Non-Respiratory Diseases

Surfactant Protein D in Respiratory and Non-Respiratory Diseases

The Dual Role of Surfactant Protein-D in Vascular Inflammation and Development of Cardiovascular Disease

Transcriptome-wide association study identified candidate genes associated with gut microbiota

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