Serum Sulfhydryl Levels in Rheumatoid Patients Treated with Gold Thiomalate and Penicillamine

Haataja, M.; Nissilä, M; Ruutsalo, Helka-Marjatta

doi:10.3109/03009747809095657

Cited by 21 publications

(19 citation statements)

References 5 publications

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“…As quoted in the introduction, the same ability has been found in the long-acting antirheumatic drugs hydroxychloquine (Pickup et al, 1980), aurothiomalate and penicillamine (Evans, 1977;Haataja et al, 1978;Hall & Gillan, 1979;Pickup et al, 1980), levamisole (Hall & Gillan, 1979), and cyclophosphamide (Grimaldi, 1980a), irrespective of whether the drug molecule contains a thiol group.…”

mentioning

confidence: 72%

Long‐term low dose haloperidol treatment in rheumatoid patients: effects on serum sulphydryl levels, technetium index, ESR, and clinical response [letter]

Mg¹

1981

Brit J Clinical Pharma

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mentioning

confidence: 72%

Long‐term low dose haloperidol treatment in rheumatoid patients: effects on serum sulphydryl levels, technetium index, ESR, and clinical response [letter]

Mg¹

1981

Brit J Clinical Pharma

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“…Total serum protein SH concentrations are significantly lower in RA patients with active disease compared with age and sex matched normal subjects, and the lowering of SH serum levels correlates with the clinical course of RA (Haataja, 1975;Lorber et al, 1971). As quoted in the introduction, the longacting antirheumatic drugs aurothiomalate and Dpenicillamine (Evans, 1977;Haataja et al, 1978;Hall & Gillan, 1979;Pickup et al, 1980), levamisole (Hall & Gillan, 1979), and hydroxychloroquine (Pickup et al, 1980) have been shown to be able to induce in long-term treated RA patients a significant increase of SH serum levels with a return of these towards the normal range along with clinical improvement, irrespectively of whether the drug molecule contains a thiol group.…”

Section: Discussionmentioning

confidence: 99%

Long‐term cyclophosphamide treatment in rheumatoid patients: effects on serum sulphydryl levels, technetium index, ESR and clinical response.

Mg¹

1981

Brit J Clinical Pharma

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1 After 12 months cyclophosphamide administration the serum sulphydryl concentrations increased in all of twelve rheumatoid patients treated, and returned towards the normal range in eleven. 2 A decrease was observed in the technetium index, the erythrocyte sedimentation rate, and joint count. 3 Long‐term cyclophosphamide‐induced serum SH increase may represent a specific change in the process of the rheumatoid disease activity, possibly involving the pathogenic B cells.

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“…For our primary analysis of all 132 studies (represented by 130 publications) we used the most frequently reported outcome, TJC. This included imputed TJC values for studies that did not measure TJC (eMethods 5 in Supplement 1), denominated TJCi.…”

Section: Methodsmentioning

confidence: 99%

Monotreatment With Conventional Antirheumatic Drugs or Glucocorticoids in Rheumatoid Arthritis

Guski,

Jürgens,

Pedder

et al. 2023

JAMA Netw Open

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ImportanceThis is the first network meta-analysis to assess outcomes associated with multiple conventional synthetic disease-modifying antirheumatic drugs and glucocorticoid.ObjectiveTo analyze clinical outcomes after treatment with conventional synthetic disease-modifying antirheumatic drugs and glucocorticoid among patients with rheumatoid arthritis.Data SourcesWith no time restraint, English language articles were searched in MEDLINE, Embase, Cochrane Central, ClinicalTrials.gov, and reference lists of relevant meta-analyses until September 15, 2022.Study SelectionFour reviewers in pairs of 2 independently included controlled studies randomizing patients with rheumatoid arthritis to mono–conventional synthetic disease-modifying antirheumatic drugs, glucocorticoid, placebo, or nonactive treatment that recorded at least 1 outcome of tender joint count, swollen joint count, erythrocyte sedimentation rate, and C-reactive protein level. Of 1098 assessed articles, 130 articles (132 interventions) were included.Data Extraction and SynthesisThe review followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses reporting guideline, and data quality was assessed by the Cochrane risk of bias tool RoB 2. Data were extracted by a single author and checked independently by 2 authors. Data were analyzed using a random effect model, and data analysis was conducted from June 2021 to February 2023.Main Outcomes and MeasuresA protocol with hypothesis and study plan was registered before data recording. The most complete of recorded outcomes (tender joint count) was used as primary outcome, with imputations based on other outcomes to obtain a full analysis of all studies. Absolute change adjusted for baseline disease activity was assessed.ResultsA total of 29 interventions in 275 treatment groups among 132 randomized clinical trials (mean [range], 71.0% [27.0% to 100%] females in studies; mean [range] of ages in studies, 53 [36 to 70] years) were identified, which included 13 260 patients with rheumatoid arthritis. The mean (range) duration of RA was 79 (2 to 243) months, and the mean (range) disease activity score was 6.3 (4.0 to 8.8). Compared with placebo, oral methotrexate was associated with a reduced tender joint count by 5.18 joints (95% credible interval [CrI], 4.07 to 6.28 joints). Compared with methotrexate, glucocorticoid (−2.54 joints; 95% CrI, −5.16 to 0.08 joints) and remaining drugs except cyclophosphamide (6.08 joints; 95% CrI, 0.44 to 11.66 joints) were associated with similar or lower tender joint counts.Conclusions and RelevanceThis study’s results support the present role of methotrexate as the primary reference conventional synthetic disease-modifying antirheumatic drug.

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Serum Sulfhydryl Levels in Rheumatoid Patients Treated with Gold Thiomalate and Penicillamine

Cited by 21 publications

References 5 publications

Long‐term low dose haloperidol treatment in rheumatoid patients: effects on serum sulphydryl levels, technetium index, ESR, and clinical response [letter]

Long‐term low dose haloperidol treatment in rheumatoid patients: effects on serum sulphydryl levels, technetium index, ESR, and clinical response [letter]

Long‐term cyclophosphamide treatment in rheumatoid patients: effects on serum sulphydryl levels, technetium index, ESR and clinical response.

Monotreatment With Conventional Antirheumatic Drugs or Glucocorticoids in Rheumatoid Arthritis

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