Serum sulfate level and Slc13a1 mRNA expression remain unaltered in a mouse model of moderate vitamin D deficiency

Atcheson, Ranita J; Dawson, Paul A.

doi:10.1007/s11010-022-04634-7

Mol Cell Biochem

2022

DOI: 10.1007/s11010-022-04634-7

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Serum sulfate level and Slc13a1 mRNA expression remain unaltered in a mouse model of moderate vitamin D deficiency

Ranita J Atcheson

Paul A. Dawson

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2024

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Cited by 2 publications

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Analytical methods for quantitating sulfate in plasma and serum

Vijayakumar,

Dawson

2024

Essays in Biochemistry

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Circulating sulfate needs to be maintained at sufficiently high levels for healthy growth and development. Animal studies have shown the adverse physiological consequences of low circulating sulfate level on the skeletal, neurological and reproductive systems. However, sulfate is not routinely measured in clinical investigations, despite the importance of sulfate being documented over the past several decades. Several methods have been developed for measuring serum and plasma sulfate level in animals and humans, including a range of barium sulfate precipitation techniques that have been a major focus of sulfate analytics since the 1960s. Evaluation of an ion chromatography method demonstrated its utility for investigation of sulfate levels in human health. More recently, liquid chromatography-tandem mass spectrometry has been used to show hyposulfatemia in a human case of mild skeletal dysplasia. This article provides an overview of analytical methods for measuring sulfate in serum and plasma, highlighting the strengths and limitations of each method.

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Analytical methods for quantitating sulfate in plasma and serum

Vijayakumar,

Dawson

2024

Essays in Biochemistry

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Sulfate: a neglected (but potentially highly relevant) anion

den Bakker,

Smith,

Finken

et al. 2024

Essays in Biochemistry

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Sulfate is an important anion as sulfonation is essential in modulation of several compounds, such as exogens, polysaccharide chains of proteoglycans, cholesterol or cholesterol derivatives and tyrosine residues of several proteins. Sulfonation requires the presence of both the sulfate donor 3′-phosphoadenosine-5′-phosphosulfate (PAPS) and a sulfotransferase. Genetic disorders affecting sulfonation, associated with skeletal abnormalities, impaired neurological development and endocrinopathies, demonstrate the importance of sulfate. Yet sulfate is not measured in clinical practice. This review addresses sulfate metabolism and consequences of sulfonation defects, how to measure sulfate and why we should measure sulfate more often.

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Serum sulfate level and Slc13a1 mRNA expression remain unaltered in a mouse model of moderate vitamin D deficiency

Cited by 2 publications

References 24 publications

Analytical methods for quantitating sulfate in plasma and serum

Analytical methods for quantitating sulfate in plasma and serum

Sulfate: a neglected (but potentially highly relevant) anion

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