Serum sTWEAK levels in chronic periodontitis and type 2 diabetes mellitus

Acharya, Anirudh B.; Chandrashekar, Apoorva; Acharya, Swetha; Shettar, Leena; Thakur, Srinath

doi:10.1016/j.dsx.2019.03.027

Cited by 7 publications

(11 citation statements)

References 45 publications

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“…For example, an elevated level of serum proteinase 3 (PR3) was determined in latent autoimmune diabetes mellitus in adults (LADA) patients by Yu et al suggesting PR3 to be a potential biomarker for differentiating LADA and T2DM patients [25]. As Acharya et al reported that serum Soluble Tumor Necrosis Factor-like Weak inducer of apoptosis (sTWEAK) level was lower in chronic periodontitis (CP) with T2DM patients than both CP and healthy individuals, and showed significant association with glycemic levels, indicating its potential role in T2DM [26]. Another study by Huang et al reported that serum haptoglobin (Hp) levels were significantly Fig.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic significance of serum PP4R1 and its predictive value for the development of chronic complications in patients with type 2 diabetes mellitus

Peng

Yang

et al. 2021

Diabetol Metab Syndr

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Background Protein phosphatase 4 regulatory subunit 1 (PP4R1) is one of the regulatory subunits of PP4. It has been determined to be involved in the regulation of TNF-α-induced hepatic insulin resistance and gluconeogenesis. Considering the important role of PP4R1 in hepatic insulin resistance, the current study explored the expression and diagnostic value of PP4R1 in type 2 diabetes mellitus (T2DM) patients and further investigated its predictive value for the development of chronic complications. Method Hundred and five patients with T2DM and 97 healthy controls were collected. qRT-PCR was used for the measurement of serum PP4R1 mRNA level in both T2DM and control groups. The diagnostic value of PP4R1 in T2DM patients was evaluated using receiver operating characteristic (ROC) curve. Kaplan-Meier methods and Cox regression analysis were used to evaluate the predictive value of PP4R1 for the development of chronic complications in T2DM patients. Results PP4R1 was determined to be elevated in the serum of T2DM patients compared with healthy controls. Serum PP4R1 had the potential to distinguish T2DM patients from healthy controls with a sensitivity of 81.9% and specificity of 82.5%. Patients with high PP4R1 expression experienced more chronic complications events. The multivariate Cox analysis results suggested that serum PP4R1 expression was an independent factor for the occurrence of chronic complications for T2DM patients. Conclusion PP4R1 is elevated in the serum of T2DM patients, had the potential to distinguish T2DM patients from healthy controls. PP4R1 serves as a promising biomarker for predicting the risk of future chronic complications in T2DM patients.

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Section: Discussionmentioning

confidence: 99%

Diagnostic significance of serum PP4R1 and its predictive value for the development of chronic complications in patients with type 2 diabetes mellitus

Peng

Yang

et al. 2021

Diabetol Metab Syndr

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“…The second class of receptors has several ligands, TNFSF12 (or tumor necrosis factorlike weak inducer of apoptosis (TWEAK)). TNFSF12 is expressed by leukocytes and is degraded to a soluble form in response to inflammatory stimuli [4]. TNFSF12 activates the NF-κB, ERK1/2 and p38 pathways and regulates proliferation, migration, differentiation, apoptosis, angiogenesis, and inflammation [4].…”

Section: Introductionmentioning

confidence: 99%

Tumour Necrosis Receptor Superfamily Interact with the Mitochondrial Dynamics in Adipose Tissue in Obese Patients without Type 2 Diabetes

Skuratovskaia¹,

Komar²,

Vulf³

et al. 2021

Preprint

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Interactions between receptors and ligands of the tumor necrosis factor superfamily (TNFSF) provide costimulatory signals that control the survival, proliferation, differentiation, and effector function of immune cells. All components of the TNF superfamily are associated with NF-kB functions that are not limited to cell death and may promote survival in the face of adipose tissue inflammation in obesity. Inflammation and pro-inflammatory dysfunction of mitochondria are key factors associated with insulin resistance in obesity. The aim of the study was to analyze the relationship of soluble forms of receptors and ligands of the TNF superfam-ily in blood plasma with mitochondrial dynamics in adipose tissue (greater omentum (GO) and subcutaneous adipose tissue (Sat)) of obese patients with and without type 2 diabetes mellitus (T2DM). Increased plasma sTNF-R1, sTNF-R2, sTNFRSF8 receptors and ligands TNFSF12, TNFSF13, TNFSF13B are characteristic of obese patients without T2DM. Increases in TNFSF12, TNFSF13B, and sTNF-R1 levels are associated with decreased glucose concentration and decreased BMI in obese patients. The gene expression levels responsible for regulating mitochondrial dynamics were increased in obese patients without T2DM and were unbalanced in patients with obesity and T2DM.

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“…The second class of receptors has several ligands, TNFSF12 (or tumor necrosis factor-like weak inducer of apoptosis (TWEAK)). TNFSF12 is expressed by leukocytes and is degraded to a soluble form in response to inflammatory stimuli [ 4 ]. TNFSF12 activates the NF-κB, ERK1/2, and p38 pathways and regulates proliferation, migration, differentiation, apoptosis, angiogenesis, and inflammation [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…TNFSF12 is expressed by leukocytes and is degraded to a soluble form in response to inflammatory stimuli [ 4 ]. TNFSF12 activates the NF-κB, ERK1/2, and p38 pathways and regulates proliferation, migration, differentiation, apoptosis, angiogenesis, and inflammation [ 4 ]. The role of TNFSF12 in adipose tissue (AT) and obesity is controversial.…”

Section: Introductionmentioning

confidence: 99%

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Tumor Necrosis Receptor Superfamily Interact with Fusion and Fission of Mitochondria of Adipose Tissue in Obese Patients without Type 2 Diabetes

et al. 2021

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Interactions between receptors and ligands of the tumor necrosis factor superfamily (TNFSF) provide costimulatory signals that control the survival, proliferation, differentiation, and effector function of immune cells. All components of the TNF superfamily are associated with NF-kB functions that are not limited to cell death and may promote survival in the face of adipose tissue inflammation in obesity. Inflammation dysfunction of mitochondria is a key factor associated with insulin resistance in obesity. The aim of the study was to analyze the relationship of soluble forms of receptors and ligands of the TNF superfamily in blood plasma with mitochondrial dynamics in adipose tissue (greater omentum (GO) and subcutaneous adipose tissue (Sat)) of obese patients with and without type 2 diabetes mellitus (T2DM). Increased plasma sTNF-R1, sTNF-R2, sTNFRSF8 receptors, and ligands TNFSF12, TNFSF13, TNFSF13B are characteristic of obese patients without T2DM. The TNF-a levels in blood plasma were associated with a decrease in MFN2 gene expression in GO and IL-10 in blood plasma. The TNFSF12 levels contributed to a decrease in glucose levels, a decrease in BMI, and an increase in IL-10 levels by influencing the MFN2 gene expression in GO, which supports mitochondrial fusion.

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Serum sTWEAK levels in chronic periodontitis and type 2 diabetes mellitus

Cited by 7 publications

References 45 publications

Diagnostic significance of serum PP4R1 and its predictive value for the development of chronic complications in patients with type 2 diabetes mellitus

Diagnostic significance of serum PP4R1 and its predictive value for the development of chronic complications in patients with type 2 diabetes mellitus

Tumour Necrosis Receptor Superfamily Interact with the Mitochondrial Dynamics in Adipose Tissue in Obese Patients without Type 2 Diabetes

Tumor Necrosis Receptor Superfamily Interact with Fusion and Fission of Mitochondria of Adipose Tissue in Obese Patients without Type 2 Diabetes

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