Serum sperm antibodies are not elevated after mumps orchitis

Kalaydjiev, S.; Dimitrova, D.; Nenova, M.; Peneva, Siika; Dikov, I; Nakov, L

doi:10.1016/s0015-0282(01)02926-0

Cited by 18 publications

(10 citation statements)

References 18 publications

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“…A number of investigators have demonstrated the presence of cross-reactivity between antigens of spermatozoa and some micro-organisms by different techniques. Common antigenicity has been found between spermatozoa and: E. coli, streptococcal antigens, T. vaginalis, M. hominis, U. urealyticum [9][10][11][12][13][14][15][16]42]. Of special interest is the cross-reactivity between sperm antigens and carbohydrate antigens on bacterial walls revealed by Kurpisz et al [11,12].…”

Section: Resultsmentioning

confidence: 99%

“…This may be due to crossreactivity between antigens of spermatozoa and some exogenous antigens of bacteria, viruses, fungi, and allergens. Common antigenicity has been found between spermatozoa and: streptococci, Streptococcus viridans, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Candida albicans, Ureaplasma urealyticum, Chlamydia trachomatis, Escherichia coli and Salmonella typhi [9][10][11][12][13][14][15][16]. On the other hand, data concerning the presence of cross-reacting antigens of spermatozoa and Helicobacter pylori, as well as association between H. pylori infection and infertility are scarce.…”

Section: Introductionmentioning

confidence: 99%

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Association between Helicobacter pylori infection and the presence of anti-sperm antibodies

Dimitrova-Dikanarova

Lazarov

Tafradjiiska-Hadjiolova

et al. 2016

Biotechnology & Biotechnological Equipment

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The aim of this study was to investigate the possible association between serum anti-Helicobacter pylori antibodies and anti-sperm antibodies (ASA) in patients with gastroduodenal diseases caused by H. pylori, infertile patients positive for ASA and healthy fertile blood donors as controls. Serum ASA were studied by sperm agglutination tests, sperm immobilization test and ELISA against sperm antigens (ELISAsp). Serum IgG anti-H. pylori antibodies were detected by ELISA (ELISAHp). The tests revealed significantly higher incidence of ASA in patients with gastroduodenal diseases compared to the controls (P < 0.0001). The median levels of both types of antibodies were significantly higher in infertile patients than in patients with upper gastroduodenal diseases in all tests applied (sperm agglutination and immobilization tests P < 0.0001; ELISAsp P D 0.006; ELISAHp, P D 0.0008). Significant linear correlation was found between anti-H. pylori antibodies and ASA detected by sperm immobilization test (r D 0.613, P D 0.05) in the group of patients with gastroduodenal disease, as well as a weak linear correlation was established between anti-H. pylori antibodies and ASA in ELISAsp (r D 0.275, P D 0.0051) in the same group. These results suggest that H. pylori infection may play a role in the induction of ASA.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between Helicobacter pylori infection and the presence of anti-sperm antibodies

Dimitrova-Dikanarova

Lazarov

Tafradjiiska-Hadjiolova

et al. 2016

Biotechnology & Biotechnological Equipment

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“…2% der Patienten eine (Epididymo)Orchitis an [5], ande rerseits belegt eine Studie aus der Mon golei das erhöhte Risiko für Einschrän kungen der Ejakulatqualität in diesen Fäl len (OddsRatio nach Mumpsorchitis 3,4; nach anderen Orchitiden 2,3; [18]). [5,19,20]. Eine Ausnahme stellt die oben ge nannte idiopathische Form der granulo matösen Orchitis dar [3].…”

Section: Testikuläre Entzündungsreak-tionen Bei Infertilen Männernunclassified

Orchitis und Infertilität

Schuppe

Pilatz

Hossain

et al. 2010

Urologe

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Infections and inflammations of the genital tract are considered the most frequent causes of reduced male fertility, but conclusive epidemiological data are not available. In view of the exposure of germ cells to pathogenic components as well as the cells and mediators involved in the inflammatory processes, irreversible damage to spermatogenesis and corresponding decline of ejaculate quality are to be expected, particularly in cases of chronic orchitis. While the consequences of orchitis and epididymo-orchitis that exhibit clinical symptoms due to systemic or local infections are well known, including testicular atrophy and complete loss of fertility, those cases of inflammatory reactions of the testicles that manifest an asymptomatic or subclinical course, or are not even due to an infection, have received little attention until now. However, systematic histopathological analyses have shown a high prevalence of asymptomatic inflammatory reactions in testicular biopsies from infertile men. The mostly focal lymphocytic infiltrates correlate with the degree of damage to spermatogenesis and corresponding clinical and endocrinological parameters of testicular function. Noninvasive diagnostic techniques are not yet available so that chronic asymptomatic inflammations of the testicles as the primary cause or cofactor of male fertility disorders are underestimated. Except for administration of pathogen-specific antibiotics, treatment recommendations are to a large extent still lacking.

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“…Nach einer Mumpsorchitis konnten jedoch nur in wenigen Fällen mäßig erhöhte Spermatozoenantikörpertiter im Serum nachgewiesen werden [36]. Auch bei infertilen Männern mit testikulären Entzündungsreaktionen zeigte sich nur ein geringer Trend zu erhöhten Spermatozoenantikörpertitern im Serum [68].…”

Section: Hinweise Zur Entstehungunclassified

Immunologie des Hodens

Meinhardt

Schuppe

2003

Reproduktionsmedizin

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Serum sperm antibodies are not elevated after mumps orchitis

Cited by 18 publications

References 18 publications

Association between Helicobacter pylori infection and the presence of anti-sperm antibodies

Association between Helicobacter pylori infection and the presence of anti-sperm antibodies

Orchitis und Infertilität

Immunologie des Hodens

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