Serum‐Soluble Selectin Levels in Patients with Rheumatoid Arthritis and Systemic Sclerosis

Abstract

Soluble forms of selectins may play a regulatory role in inflammatory responses that are key to the pathophysiology of rheumatic diseases such as rheumatoid arthritis

Blood Serum Levels of Amino-Terminal Pro-C-Type Natriuretic Peptide in Patients with Systemic Sclerosis

“…Moreover, higher levels of sE-selectin in patients with SSc compared with healthy controls were observed, consistent with the results from other studies [14,20]. Despite endothelial origin of both sE-selectin and NT-proCNP and their role in inflammatory process, we failed to detect the significant correlation between the molecules.…”

“…Ates et al [14] reported that serum sP-selectin concentrations were similar in patients with SSc and controls, but sE-selectin levels were found to be increased in the SSc group. Regarding sP-selectin, the discrepancy between our results and those by Ates et al may come from different patient profiles in both studies.…”

“…Selectins, a family of three adhesion molecules responsible for leukocyte rolling [13], may contribute to SSc pathogenesis. Despite not precisely known function, soluble selectins show some potential as markers of disease severity in SSc [14]. However, endothelium-derived paracrine factor CNP exerts cytoprotective and anti-inflammatory effects, suppresses expression of adhesion molecules [6,15], and acts as a powerful vasodilator [4].…”

Effect of Bosentan on Plasma Markers of Endothelial Cell Activity in Patients with Secondary Pulmonary Hypertension Related to Connective Tissue Diseases

“…This interaction is in part modulated by ET-1, which, through inhibition of P-selectin upregulation, prevents interactions between leukocytes and endothelium, particularly in the presence of vasoconstriction and inflammation 30 . As P-selectin levels in patients with SSc may also be related to extensive systemic inflammation 31,32 , it is possible that the antagonist effect of bosentan on ET-1 receptor disrupts the compensatory mechanism, eventually leading to sP-S upregulation. This complex interaction may eventually translate into treatment failure.…”

Platelet function in rheumatoid arthritis: arthritic and cardiovascular implications

“…The role of P-selectin expression may vary widely, depending on the presence of articular and extra-articular rheumatoid manifestations. This is why in some observations soluble P-selectin levels were close to normal [71] or there were no associations with shifts of immune markers (e.g., soluble IL-2 receptor, a modulating protein of T-lymphocyte activity) [61].…”